Endotoxin pp 557-559 | Cite as

The Mechanism of Adjuvant Action of Bacterial Lipopolysaccharide (LPS) in Subcutaneous Immunization

  • Y. Inoue
  • T. Yokochi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)

Abstract

Bacterial lipopolysaccharide (LPS) exhibits an adjuvant action on antibody response to various antigens in mice. The adjuvant action induced by subcutaneous (s.c.) injection of LPS with antigen is different from that by intraperitoneal (i.p.) or intravenous (i.v.) injection (2). In the present study, we investigated histological changes at the regional s.c. tissues after injection with LPS and the tissue distribution of the LPS. It was suggested that there were two distinct mechanisms of adjuvant action which operated at the early and late stages after s.c. immunization, respectively.

Keywords

Regional Site Lymphoid Follicle Bacterial Lipopolysaccharide Adjuvant Action Phenol Water 
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References

  1. 1.
    Braun, D. G., Hild, K. and Ziegler, A., 1979, Resolution of immunoglobu- lin patterns by analytical isoelectrofocusing, in: “Immunological Methods,” I. Lefkovits and B. Permis, eds., Academic Press, New York.Google Scholar
  2. 2.
    Nakashima, I., Nagase, F., Matsuura, A., Yokochi, T. and Kato, N., 1980, Adjuvant actions of polyclonal lymphocyte activators. III. Two distinct types of T-initiating adjuvant action demonstrated under different experimental conditions. Cell Immunol. 52: 429.Google Scholar
  3. 3.
    Noyes, H. E., Mclnturf, C. R. and Blahuta, G. J., 1959, Studies on distribution of Escherichia coli endotoxin in mice. Pro. Soc. Exp. Biol. and Med. 100: 65.Google Scholar
  4. 4.
    Westphal, 0., 1975, Bacterial endotoxins. Int. Rev. Allergy Appl. Immunol. 49: 1.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Y. Inoue
    • 1
  • T. Yokochi
    • 1
  1. 1.Department of MicrobiologyFukui Medical SchoolFukuiJapan

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