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Endotoxin pp 557–559Cite as

The Mechanism of Adjuvant Action of Bacterial Lipopolysaccharide (LPS) in Subcutaneous Immunization

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 256))

Abstract

Bacterial lipopolysaccharide (LPS) exhibits an adjuvant action on antibody response to various antigens in mice. The adjuvant action induced by subcutaneous (s.c.) injection of LPS with antigen is different from that by intraperitoneal (i.p.) or intravenous (i.v.) injection (2). In the present study, we investigated histological changes at the regional s.c. tissues after injection with LPS and the tissue distribution of the LPS. It was suggested that there were two distinct mechanisms of adjuvant action which operated at the early and late stages after s.c. immunization, respectively.

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References

  1. Braun, D. G., Hild, K. and Ziegler, A., 1979, Resolution of immunoglobu- lin patterns by analytical isoelectrofocusing, in: “Immunological Methods,” I. Lefkovits and B. Permis, eds., Academic Press, New York.

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Author information

Authors and Affiliations

  1. Department of Microbiology, Fukui Medical School, Fukui, 910-11, Japan

    Y. Inoue & T. Yokochi

Authors
  1. Y. Inoue
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  2. T. Yokochi
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Editor information

Editors and Affiliations

  1. The University of South Florida, Tampa, Florida, USA

    Herman Friedman  & T. W. Klein  & 

  2. Jichi Medical School, Tochigi-Ken, Japan

    Masayasu Nakano

  3. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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© 1990 Springer Science+Business Media New York

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Inoue, Y., Yokochi, T. (1990). The Mechanism of Adjuvant Action of Bacterial Lipopolysaccharide (LPS) in Subcutaneous Immunization. In: Friedman, H., Klein, T.W., Nakano, M., Nowotny, A. (eds) Endotoxin. Advances in Experimental Medicine and Biology, vol 256. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5140-6_49

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  • DOI: https://doi.org/10.1007/978-1-4757-5140-6_49

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5142-0

  • Online ISBN: 978-1-4757-5140-6

  • eBook Packages: Springer Book Archive

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