Endotoxin pp 549-556 | Cite as

The Mediation of Endotoxin-Induced Beneficial Effects by Cytokines

  • R. Urbaschek
  • B. Urbaschek
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)


Endotoxins, when entering the circulation in sufficient amounts, elicit multiple effects that can lead to shock and death. Besides these detrimental effects, endotoxins in minute concentrations may nonspecifically contribute to regulate the steady state of host defense. Moreover, various experimental approaches have shown, already in the early years of endotoxin research, that injection of small amounts of extracted endotoxins can induce beneficial effects, such as tolerance to the pyrogenic and lethal effects of endotoxin, nonspecific resistance to microbial infections and irradiation disease, stimulation of hematopoiesis, as well as tumor regression. These beneficial effects of endotoxins have been reviewed recently (13).


Tumor Necrosis Factor Kupffer Cell Lethal Effect Cecal Ligation NMRI Mouse 
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  1. 1.
    Belosevic, M., Davis, C. E., Meltzer, M. S., and Nacy, C. A., 1988, Regulation of activated macrophage antimicrobial activities, Identification of lymphokines that cooperate with IFN- Y for induction of resistance to infection. J. Immunol. 141: 890.Google Scholar
  2. 2.
    Broxmeyer, H. E., Williams, D. E., Lu, L., Cooper, S., Anderson, S. L., Beyer, G. S., Hoffman, R., and Rubin, B. Y., 1986, The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-Y, J. Immunol. 136: 4487.Google Scholar
  3. 3.
    Czuprynski, C. J., and Brown, J. F., 1987, Recombinant murine interleukin-1 enhancement of nonspecific antibacterial resistance. Infect. Immun. 55: 2061.Google Scholar
  4. 4.
    Dinarello, C. A., 1987, The biology of interleukin 1 and comparison to tumor necrosis factor. Immunol. Letters 16: 227.Google Scholar
  5. 5.
    Dinarello, C. A., Cannon, J. G., and Wolff, S. M., 1988, New concepts on the pathogenesis of fever, in: “Perspectives on Bacterial Pathogenesis and Host Defense,” B. Urbaschek, ed., The University of Chicago Press, Chicago.Google Scholar
  6. 6.
    Ditter, B., Becker, K.-P., Urbaschek, R., and Urbaschek, B., 1983, Quantitativer Endotoxinnachweis. Automatisierter, kinetischer Limulus-Amobozyten-Lysat Mikrotiter-Test mit Messung probenabhingiger Interferenzen. ArzneimittelForsch/Drug Res. 33: 681.Google Scholar
  7. 7.
    Fraker, D. L., Stovroff, M. C., Merino, M. J., and Norton, J. A., 1988, Tolerance to tumor necrosis factor in rats and the relationship to endotoxin tolerance and toxicity. J. Exp. Med. 168: 95.Google Scholar
  8. 8.
    Friedman, H., Blanchard, D. K., Newton, C., Klein, T., Stewart, II, W., Keler, T., and Nowotny, A., 1987, Distinctive immunomodulatory effects of endotoxin and nontoxic lipopolysaccharide derivatives in lymphoid cell cultures. J. Biol. Resp. Modif. 6: 664.Google Scholar
  9. 9.
    Greer, G. G., and Rietschel, E. Th., 1978. Inverse relationship between the susceptibility of lipoplysaccharide (lipid A)-pretreated mice to the hypothermic and lethal effect of lipopolysaccharide. Infect. Immun. 20: 366.Google Scholar
  10. 10.
    Greisman, S. E., 1983, Induction of endotoxin tolerance, in: “Beneficial Effects of Endotoxins,” A. Nowotny, ed., Plenum Press, New York.Google Scholar
  11. 11.
    McCuskey, R. S., Urbaschek, R., McCuskey, P. A., and Urbaschek, B., 1983, In vivo microscopic observations of the responses of Kupffer cells and the hepatic microcirculation to Mycobacterium bovis BCG alone and in combination with endotoxin. Infect. Immun. 42: 362.Google Scholar
  12. 12.
    Neta, R., Douches, S. D., and Oppenheim, J. J., 1986, Interleukin-1 is a radioprotector. J. Immunol. 136: 2483.Google Scholar
  13. 13.
    Nowotny, A., 1983, “Beneficial Effects of Endotoxins,” Plenum Press New YorkGoogle Scholar
  14. 14.
    Ozaki, Y., Ohashi, T., Minami, A., and Nakamura, S.-I., 1987, Enhanced resistance of mice to bacterial infection induced by recombinant human interleukin-la, Infect. Immun. 55: 1436.Google Scholar
  15. 15.
    Rietschel, E. Th., Schade, U., Jensen, M., Wollenweber, H. W., Lüüderitz, O., and Greisman, S. E., 1982, Bacterial endotoxins: Chemical structure, biological activity and role in septicaemia. Scand. J. Infect. Dis. 31 (Suppl.): 8.Google Scholar
  16. 16.
    Rothstein, J. L., and Schreiber, H., 1988, Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice. Proc. Natl. Acad. Sci. (USA) 85: 607.Google Scholar
  17. 17.
    Urbaschek, B., Ditter, B., Becker, K.-P., and Urbaschek, R., 1984, Protective effects and role of endotoxin in experimental septicemia. Circ. Shock 14: 209.Google Scholar
  18. 18.
    Urbaschek, R., and Urbaschek, B., 1982, Aspects of beneficial endotoxinmediated effects. Kiin. Wochenschr. 60: 746.Google Scholar
  19. 19.
    Urbaschek, R., and Urbaschek, B., 1983, Ability of post-endotoxin serum from BCG-infected mice to induce nonspecific resistance and stimulation of granulopoiesis. Infect. Immun. 39: 1488.Google Scholar
  20. 20.
    Urbaschek, R., Männel, D. N., Mergenhagen, S. E., and Urbaschek, B., 1986, The role of post-endotoxin serum components from BCG infected mice in the protection of compromised hosts, in: “Immunobiology and Immunopharmacology of Bacterial Endotoxins,” A—Szentivanyi, H. Friedman, and A. Nowotny,Plenum Press, New York.Google Scholar
  21. 21.
    Urbaschek, R., Iannel, D. N., and Urbaschek, B., 1987, Tumor necrosis factor induced stimulation of granulopoiesis and radioprotection. Lymph. Res. 6: 179.Google Scholar
  22. 22.
    Urbaschek, R., and Urbaschek, B., 1987, Tumor necrosis factor and interleukin 1 as mediators of endotoxin-induced beneficial effects. Rev. Infect. Dis. 9: S607.Google Scholar
  23. 23.
    Urbaschek, R., Urbaschek, B., and Ribi, E., 1985, Induction of nonspecific resistance, endotoxin tolerance and colony-stimulating activity (CSA) by nontoxic LPS components. Fed. Proc. 44: 1490.Google Scholar
  24. 24.
    Vogel, S. N., Douches, S. D., Kaufman, E. N., Neta, R., 1987, Induction of colony stimulating factor in vivo by recombinant interleukin 1 a and recombinant tumor necrosis factor a. J. Immunol. 138: 2143.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • R. Urbaschek
    • 1
  • B. Urbaschek
    • 1
  1. 1.Department of Immunology and Serology, Institute of Medical Microbiology and Hygiene, Klinikum MannheimUniversity of HeidelbergMannheimGermany

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