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Various Aspects of Synergism between Endotoxin and MDPs

  • Chapter
Endotoxin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 256))

Abstract

Muramyl dipeptide (MDP) is a synthetic glycopeptide analog of a part of bacterial peptidoglycan (13). It represents the minimal adjuvant-active structure and has also been shown to stimulate nonspecific resistance in animals subsequently infected (9). These effects have been demonstrated after injecting MDP in saline by different routes. The synthesis of MDP was followed by the preparation of a large number of derivatives with the hope of determining structure-activity relationships (12, 15), or at least of selecting immunostimulating compounds, which did not retain several side effects inherent to MDP administration (6, 24). Such an evaluation has allowed us to select an MDP derivative called Murabutide which is undergoing clinical trials with conventional vaccines after its safety has been established by animal toxicological studies, and in a phase I clinical trial.

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Author information

Authors and Affiliations

  1. Laboratory of Experimental Immunopharmacology, Institut Biomédical des Cordeliers, 75006, Paris, France

    M. Parant

  2. University of South Florida, Tampa, FL, USA

    L. Chedid

Authors
  1. M. Parant
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  2. L. Chedid
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Editor information

Editors and Affiliations

  1. The University of South Florida, Tampa, Florida, USA

    Herman Friedman  & T. W. Klein  & 

  2. Jichi Medical School, Tochigi-Ken, Japan

    Masayasu Nakano

  3. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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© 1990 Springer Science+Business Media New York

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Parant, M., Chedid, L. (1990). Various Aspects of Synergism between Endotoxin and MDPs. In: Friedman, H., Klein, T.W., Nakano, M., Nowotny, A. (eds) Endotoxin. Advances in Experimental Medicine and Biology, vol 256. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5140-6_47

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  • DOI: https://doi.org/10.1007/978-1-4757-5140-6_47

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5142-0

  • Online ISBN: 978-1-4757-5140-6

  • eBook Packages: Springer Book Archive

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