Endotoxin pp 511-523 | Cite as

Bacterial Endotoxin as a Probe to Investigate Viral Induced Immune Deficiencies

  • M. Bendinelli
  • D. Matteucci
  • P. G. Conaldi
  • E. Soldaini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)

Abstract

That viral induced immune deficiencies (VID) are a major medical problem is dramatically emphasized by the ongoing pandemic of acquired immune deficiency syndrome (AIDS). However, the ability to impair the immune system of the host is not limited to the human immune deficiency virus (HIV). The first report that viral infections may be the cause of clinically significant perturbations of immune reactivity was published long before AIDS was even dreamed of. Eighty years ago Clement von Pirquet reported that children with measles showed a transient anergy to tuberculin as evidenced by reduced skin tests. Since this pioneering work a vast array of human and animal viruses have been shown to suppress many parameters of immunological reactivity in infected hosts (for recent reviews, see 1, 27, 28, 32, 36).

Keywords

Spleen Cell Infected Mouse Bacterial Endotoxin Human Immune Deficiency Virus Friend Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bendinelli, M., 1984, Immunomodulation in viral infections: Virus or infection-induced? in: “Immunomodulation. New Frontiers and Advances,” H. H. Fudenberg, H. 157 Whitten and F. Ambrogi, eds., Plenum Press, New York.Google Scholar
  2. 2.
    Bendinelli, M., 1988, The reticuloendothelial system in infection with RNA tumor viruses, in: “The Reticuloendothelial System: A Comprehensive Treatise. Vol. 10. Infection,” M. Escobar and J. P. Utz, eds., Plenum Press, New York.Google Scholar
  3. 3.
    Bendinelli, M. and Friedman, H., 1988, “Coxsackieviruses: A General Update,” Plenum Press, New York.Google Scholar
  4. 4.
    Bendinelli, M., Matteucci, D. and Friedman, H., 1985, Retrovirus-induced acquired immunodeficiencies. Adv. Cancer Res. 45: 125.Google Scholar
  5. 5.
    Bendinelli, M., Matteucci, D., Giangregorio, A. M. and Conaldi, P. G., 1986, Restoration of antibody responsiveness by endotoxin in retrovirusimmunosuppressed mice: Role of macrophages, in: “Immunobiology and Immunopharmacology of Bacterial Endotoxins,” A. Szentivanyi, H. Friedman and A. Nowotny, eds., Plenum Press, New York.Google Scholar
  6. 6.
    Blanchard, D. K., Djeu, J. Y., Klein, T. W., Friedman, H., and Stewart, W. E., 1986, Interferon-Y induction by lipopolysaccharide: Dependence on interleukin 2 and macrophages. J. Immunol. 136: 963.Google Scholar
  7. 7.
    Boggs, S. S. and Schwartz, G. N., 1978, Increased lethality after endotoxin in old or leukemic AKR mice. Proc. Soc. Exp. Biol. Med. 157: 424.Google Scholar
  8. 8.
    Bowen, D. L., Lane, H. C. and Fauci, A. S., 1986, Immunologic abnormalities in the acquired immunodeficiency syndrome. Prog Allergy 37: 207.CrossRefGoogle Scholar
  9. 9.
    Butler, R. C., Frier, J. M., Chapekar, M. S., Graham, M. 0. and Friedman, H., 1983, Role of antibody response helper factors in immunosuppressive effects of Friend leukemia virus. Infec. Immun. 39: 1260.Google Scholar
  10. 10.
    Cerny, J., Hensgen, P. A., Fistel, S. H. and Demler, L. M., 1976, Interactions of murine leukemia virus with isolated lymphocytes. II. Infection of B and T cells with Friend virus complex in diffusion chambers and in vitro: Effect of polyclonal mitogens. Int. J. Cancer 18: 189.Google Scholar
  11. 11.
    Conaldi, P. G., Matteucci, D., Soldaini, E. and Bendinelli, M., 1988, Interactions of group B coxsackieviruses with human lymphoid cells. Proc. 88th Annu. Meet. Amer. Soc. Microbiol. p. 132.Google Scholar
  12. 12.
    Croll, A. D. and Morris, A. G., 1986, The regulation of y-interferon production by interleukins 1 and 2. Cell. Immunol. 102: 33.Google Scholar
  13. 13.
    Dracott, B. N., Wedderburn, N. and Doenhoff, M. J., 1978, The immunodepressive effect of Friend virus. IV. Effects on spleen B lymphocytes. Immunology 34: 679.PubMedGoogle Scholar
  14. 14.
    Dudding, L. R. and Garnett, H. M., 1987, Interactions of strain AD169 and a clinical isolate of cytomegalovirus with peripheral monocytes: The effect of lipopolysaccharide stimulation. J. Inf. Dis. 155: 891.Google Scholar
  15. 15.
    Duncan, R. L., Hoffman, J., Tesh, V. L. and Morrison, D. C., 1986, Immunologic activity of lipopolysaccharides released from macrophages after the uptake of intact E. coli in vitro. J. Immunol. 136: 2924.Google Scholar
  16. 16.
    Friedman, H. and Szentivanyi, A., 1986, Endotoxin and polysaccharide derivative induced enhanced antibody formation in leukemia virus infected mice, in: “Immunobiology and Immunopharmacology of Bacterial Endotoxins,” A.—Szentivanyi, H. Friedman and A. Nowotny, eds., Plenum Press, New York.Google Scholar
  17. 17.
    Genovesi, E. V., Livnat, D. and Collins, J. J., 1982, Immunotherapy of murine leukemia. VII. Prevention of Friend leukemia virus-induced immunosuppression by passive serum therapy. Int. J. Cancer 30: 609.Google Scholar
  18. 18.
    Gut, J. P., Schmitt, S.. Bingen. A., Anton, M. and Kirn, A., 1984, Probable role of endogenous endotoxins in hepatocytolysis during murine hepatitis caused by frog virus 3. J. Inf. Dis. 149: 621.Google Scholar
  19. 19.
    Ho. D. D., Pomerantz, R. J. and Kaplan, J. C., 1987. Pathogenesis of infection with human immunodeficiency virus. N. Engl. J. Med. 317: 278.Google Scholar
  20. 20.
    Ho, M.. 1983, Induction of interferon by endotoxin, in: “Beneficial Effects of Endotoxins,” A. Nowotny, ed., Plenum Press, New York.Google Scholar
  21. 21.
    Johnson, C. S. and Furmanski, P., 1987, In vivo effects of tumor necrosis factor on normal and leukemic erythropoiesis. Proc. Annu. Meet. Am. Assoc. Cancer Res. 28: 399.Google Scholar
  22. 22.
    Jones, K. S., Ruscetti, S. and Lilly, F., 1988. Loss of pathogenicity of spleen focus-forming virus after pseudotyping with Akv. J. Virol. 62: 511.Google Scholar
  23. 23.
    Kitagawa, M., Matsubara, O. and Kasuga, T., 1986, Dynamics of lymphocytic subpopulations in Friend leukemia virus-induced leukemia. Cancer Res. 46: 3034.Google Scholar
  24. 24.
    Kleinerman, E. S., Lachman, L. B., Knowles, R. D., Snyderman, R. and Cianciolo, G. J., 1987. A synthetic peptide homologous to the envelope protein of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1. J. Immunol. 139: 2329.Google Scholar
  25. 25.
    Kurt-Jones, E. A., Beller, D. I., Mizel, S. B. and Unanue, E. R., 1985. Identification of a membrane-associated interleukin 1 in macrophages. Proc. Natl. Acad. Sci. USA 82: 1204.Google Scholar
  26. 26.
    Matteucci, D., Giangregorio, A. M., Lopez-Cepero, M., Specter, S., Bendinelli, M. and Friedman, H., 1989, Interleukins 1 and 2 production and responsiveness in the early stages of leukemogenic retrovirus infection of mice. Cell. Immunol. 119, in press.Google Scholar
  27. 27.
    McChesney, M. B. and Oldstone, M. B. A., 1987, Viruses perturb lymphocyte functions: Selected principles characterizing virus-induced immunosuppression. Ann. Rev. Immunol. 5: 279.Google Scholar
  28. 28.
    Mims, C. A., 1986, Interactions of viruses with the immune system. Clin. Exp. Immunol. 66: 1.Google Scholar
  29. 29.
    Morrison, R. P, Nishio, J. and Chesebro, B.. 1986. Influence of the murine MHC (H-2) on Friend leukemia virus-induced immunosuppression. J. Exp. Med. 163: 301.Google Scholar
  30. 30.
    Beneficial Effects of Endotoxins,“ 1983, Nowotny A., ed., Plenum Press, New York.Google Scholar
  31. 31.
    Roberts, N. J., Jr., Prill, A. H. and Mann, T. N., 1986, Interleukin-1 and interleukin-1 inhibitor production by macrophages exposed to influenza virus or respiratory syncytial virus. J. Exp. Med. 163: 511.Google Scholar
  32. 32.
    Rouse, B. T. and Horohov, D. W., 1986, Immunosuppression in viral infections. Rev. Inf. Dis. 8: 850.Google Scholar
  33. 33.
    Specter, S.. Moody, D. J., Bendinelli, M. and Friedman, H., 1984, Suppression of natural killer cell activity by Friend murine leukemia virus. J. Nat. Cancer Res. 172: 1394.Google Scholar
  34. 34.
    Spickett, G. P. and Dalgleish, A. G., 1988, Cellular immunology of HIV infection. Clin. Exp. Immunol. 71: 1.Google Scholar
  35. 35.
    Steeves, R. A. and Grundke-Iqbal, I., 1976, Bacterial lipopolysaccharides as helper factors for Friend spleen focus-forming virus in mice. J. Natl. Cancer Inst. 56: 541.Google Scholar
  36. 36.
    Szentivanyi, A. and Friedman, H., 1986, “Viruses, Immunity and Immunodeficiency.” Plenum Press, New York.Google Scholar
  37. 37.
    Szentivanyi, A., Friedman, H. and Nowotny, A., 1986, “Immunobiology and Immunopharmacology of Bacterial Endotoxins,” Plenum Press, New York.Google Scholar
  38. 38.
    Unanue, E. R. and Allen, P. M., 1987, The basis for the immunoregulatory role of macrophages and other accessory cells. Science 236: 551.Google Scholar
  39. 39.
    Warner, J. O. and Marshall, W. C., 1979, Crippling lung disease after measles and adenovirus infection. Br. J. Dis. Chest 2: 89.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • M. Bendinelli
    • 1
  • D. Matteucci
    • 1
  • P. G. Conaldi
    • 1
  • E. Soldaini
    • 1
  1. 1.Department of BiomedicineVirology Section University of PisaPisaItaly

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