Endotoxin pp 499-509 | Cite as

Metabolic Fate of Endotoxin in Rat

  • M. Freudenberg
  • C. Galanos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)


Endotoxins (lipopolysaccharide, LPS) of gram-negative bacteria induce numerous biological activities which, depending on concentration of endotoxin and reactivity of the host may be either harmful or beneficial (for review see 12, 23). The pathophysiological effects of endotoxin drew much attention in the past and classical endotoxin activities like pyrogenicity, leucopenia or Shwartzman reaction were studied extensively. On the other hand, questions concerning the endotoxin itself, its pathway through the organism and its ultimate fate drew little attention and remained virtually unexplored. Thus for many years it was generally believed that the organism possesses mechanisms for detoxifying endotoxin (1, 3, 17–19, 22, 30–34, 36). Evidence for this, however, was never presented.


Bacterial Endotoxin High Density Lipo High Tissue Concentration Shwartzman Reaction Numerous Biological Activity 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • M. Freudenberg
    • 1
  • C. Galanos
    • 1
  1. 1.Max-Planck-Institut für ImmunobiologieFreiburgGermany

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