Endotoxin pp 273-285 | Cite as

Primary Structures and Functions of Anti-Lipopolysaccharide Factor and Tachyplesin Peptide Found in Horseshoe Crab Hemocytes

  • T. Muta
  • T. Nakamura
  • H. Furunaka
  • F. Tokunaga
  • T. Miyata
  • M. Niwa
  • S. Iwanaga
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)

Abstract

The component of lipopolysaccharide (LPS) located in the cell surface of Gram-negative bacteria, has various biological activities, such as pyrogenicity, adjuvant activity, activation of macrophage and B lymphocyte antitumor activity, and so on (19). It is also known that LPS induces the activation and degranulation of horseshoe crab hemocytes and results in the hemolymph coagulation (2, 7). This cellular event is thought to be one of the self-defense mechanisms of horseshoe crab (12, 18, 23). The recent studies on the limulus coagulation system indicate that it consists of the sequential activations of at least three serine protease zymogens and subsequent conversion of coagulogen, an invertebrate fibrinogen-like substance, to coagulin gel (9, 10, 14–16, 21).

Keywords

Horseshoe Crab Cationic Peptide Double Diffusion Hemocyte Lysate Tachypleus Tridentatus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • T. Muta
    • 1
  • T. Nakamura
    • 2
  • H. Furunaka
    • 2
  • F. Tokunaga
    • 1
  • T. Miyata
    • 1
    • 2
  • M. Niwa
    • 3
  • S. Iwanaga
    • 1
    • 2
  1. 1.Department of Molecular BiologyGraduate School of Medical ScienceJapan
  2. 2.Department of Biology, Faculty of ScienceKyushu University 33Fukuoka 812Japan
  3. 3.Department of BacteriologyOsaka City University Medical SchoolOsaka 565Japan

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