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Structural Requirements of Lipid a for Endotoxicity and Other Biological Activities—An Overview

  • Chapter
Endotoxin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 256))

Abstract

Lipopolysaccharide (LPS), a major constituent of outer membranes of gram-negative bacteria, exhibits a wide variety of bioactivities (Table 1) (61). In 1954 Westphal and Lüderitz proposed that the lipid moiety of LPS is responsible for most of endotoxicities, and designated it as lipid A (Fig 1) (60). However, this extremely important discovery was neither adequately nor unanimously accepted by endotoxin investigators at that time. One of the main reasons for this controversy is that the high hydrophobicity of the lipid A molecule made its manipulation as a test material for bioactivities difficult. Another reason is concerned with inherent microheterogeneity in fine structures even among preparations derived from the same bacterial

This overview is based on our recent review paper in CRC Critical Rev. Microbiol. (54).

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Authors and Affiliations

  1. Department of Microbiology and Oral Microbiology, Osaka University Dental School, 1-8 Yamadaoka, Suita, Osaka 565, Japan

    S. Kotani & H. Takada

  2. Osaka College of Medical Technology, 1-30, Higashitenma 2-chome, Kita-ku, Osaka 530, Japan

    S. Kotani

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  1. S. Kotani
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  2. H. Takada
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Editors and Affiliations

  1. The University of South Florida, Tampa, Florida, USA

    Herman Friedman  & T. W. Klein  & 

  2. Jichi Medical School, Tochigi-Ken, Japan

    Masayasu Nakano

  3. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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Kotani, S., Takada, H. (1990). Structural Requirements of Lipid a for Endotoxicity and Other Biological Activities—An Overview. In: Friedman, H., Klein, T.W., Nakano, M., Nowotny, A. (eds) Endotoxin. Advances in Experimental Medicine and Biology, vol 256. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5140-6_2

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  • DOI: https://doi.org/10.1007/978-1-4757-5140-6_2

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