Endotoxin pp 163-184 | Cite as

Chemistry and Biology of a Novel Lipid Contaminant of Some Endotoxin Preparations with Selective Cytotoxicity to Transformed Cells

  • T. Keler
  • C. A. D. Smith
  • A. Nowotny
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)


The heterogeneity of various endotoxin (ET) preparations, should they be extracted by the trichloroacetic acid method of Boivin and co-workers, or by the phenol-water procedure of Westphal and Luderitz, has been well documented (26, 27). Several papers from our laboratory elaborated on the experimental details and emphasized the significance of this observation from both chemical and biological viewpoints (23, 24, 25, 29).


802c Cell Fast Atom Bombardment Mass Spectroscopy Selective Cytotoxicity Chromium Release Assay P81S Cell 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • T. Keler
    • 1
  • C. A. D. Smith
    • 2
  • A. Nowotny
    • 1
  1. 1.The Thomas W. Evans Museum and Dental InstituteUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.National Cancer InstituteBethesdaUSA

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