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The Association of Xeroderma Pigmentosum with Trichothiodystrophy: A Clue to a Better Understanding of XP-D?

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DNA Damage and Repair

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Abstract

In 1986 we reported the results of DNA repair investigations in patients showing acute photosensitivity and clinical traits of the rare hereditary disorder trichothiodystrophy (TTD) (Stefanini et al. 1986). Cells from these patients showed a reduced capacity to repair the UV-induced DNA damage similar to that present in individuals affected by xeroderma pigmentosum (XP) and the complementation analysis demonstrated that the repair defect was the same present in XP, complementation group D (XP-D).

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Authors and Affiliations

  1. Istituto di Genetica Biochimica ed Evoluzionistica, CNR, Via Abbiategrasso, 207, 27100, Pavia, Italy

    Fiorella Nuzzo & Miria Stefanini

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  1. Fiorella Nuzzo
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  2. Miria Stefanini
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Editors and Affiliations

  1. Department of Environment and Health Protection, ENEA, Rome, Italy

    Amleto Castellani

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© 1989 Springer Science+Business Media New York

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Nuzzo, F., Stefanini, M. (1989). The Association of Xeroderma Pigmentosum with Trichothiodystrophy: A Clue to a Better Understanding of XP-D?. In: Castellani, A. (eds) DNA Damage and Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5016-4_8

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  • DOI: https://doi.org/10.1007/978-1-4757-5016-4_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5018-8

  • Online ISBN: 978-1-4757-5016-4

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