Inhibiting DNA Repair — Models, Manipulations and Misconceptions

  • Andrew Collins


The repair of DNA damage is very much a minor activity in terms of the cellular resources devoted to it. This means that investigating the biochemistry of DNA repair is rather like looking for a needle in a haystack. Consequently, in attempts to account for the mechanism of nucleotide excision repair there has been undue reliance on guesswork and extrapolation. Only recently, with the cloning of bacterial DNA repair genes and the synthesis of gene products in substantial quantities, has it been possible to work out the details of excision repair in Escherichia coli — and, as we know, the conventional model has proven wrong.


Excision Repair Nucleotide Excision Repair Cytosine Arabinoside Repair Patch Normal Human Fibroblast 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Andrew Collins
    • 1
  1. 1.Department of BiochemistryUniversity of Aberdeen Marischal CollegeAberdeenUK

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