Inhibiting DNA Repair — Models, Manipulations and Misconceptions
The repair of DNA damage is very much a minor activity in terms of the cellular resources devoted to it. This means that investigating the biochemistry of DNA repair is rather like looking for a needle in a haystack. Consequently, in attempts to account for the mechanism of nucleotide excision repair there has been undue reliance on guesswork and extrapolation. Only recently, with the cloning of bacterial DNA repair genes and the synthesis of gene products in substantial quantities, has it been possible to work out the details of excision repair in Escherichia coli — and, as we know, the conventional model has proven wrong.
KeywordsExcision Repair Nucleotide Excision Repair Cytosine Arabinoside Repair Patch Normal Human Fibroblast
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- Collins, A., 1987, Estimates of the rate of ligation during excision repair of ultraviolet-damaged DNA in mammalian cells, Biochim. Biophys. Acta 908: 103.Google Scholar
- Collins, A., Black, D.T., and Waldren, C.A., 1987, Abortive DNA repair and enhanced mutagenesis following mutagen treatment of Chinese hamster Ade C cells in a state of purine deprivation, (submitted).Google Scholar
- Collins, A.R.S., Downes, C.S., and Johnson, R.T., 1980, Cell cycle-related variations in UV damage and repair capacity in Chinese hamster (CHO-K1) cells, J. Cell. Physiol. 103: 179.Google Scholar
- Collins, A.R.S., Downes, C.S., and Johnson, R.T., 1984, An integrated view of inhibited repair, in: “DNA Repair and its Inhibition”, A. Collins, C.S. Downes and R.T. Johnson, eds, IRL Press, Oxford.Google Scholar
- Collins, A.R.S., and Johnson, R.T., 1984, The inhibition of DNA repair, Adv. Radiat. Biol. 11: 71.Google Scholar
- Collins, A., and Oates, D.J., 1987, Hydroxyurea: effects on deoxyribonucleotide pool sizes correlated with effects on DNA repair in mammalian cells, European J. Biochem. (in press)Google Scholar
- Downes, C.S., Ord, M.J., Mullinger, A.M., Collins, A.R.S., and Johnson, R.T., 1985, Novobiocin inhibition of DNA excision repair may occur through effects on mitochondrial structure and ATP metablism, not on repair topoisomerases, Carcinogenesis 6: 1343.Google Scholar
- Johnson, R.T., Collins, A.R.S., Squires, S., Mullinger, A.M., Elliott, G.C., Downes, C.S., and Rasko, I., 1987, DNA repair under stress, J. Cell Sci. Suppl. 6: 263.Google Scholar
- Mullinger, A.M., Collins, A.R.S., and Johnson, R.T., 1983, Cell growth state determines susceptibility of repair DNA synthesis to inhibition by hydroxyurea and 1- -D-arabinofuranosylcytosine, Carcinogenesis 4, 1039.Google Scholar
- Stamato, T.D., Hinkle, L., Collins, A.R.S., and Waldren, C.A., 1981, Chinese hamster ovary mutant UV-1 is hypomutable and defective in a postreplication recovery process, Somat. Cell Genet., 7: 307.Google Scholar
- Th’ng, J.P.H., and Walker, I.G., 1986, Excision repair of DNA in the presence of aphidicolin, Mutat. Res., 165: 139.Google Scholar
- Thompson, L.H., Brookman, K.W., Dillehay, L.E., Mooney, C.L., and Carrano, A.V., 1982, Hypersenstivity to mutation and sister-chromatid exchange induction in CHO cell mutants defective in incising DNA containing UV lesions, Somat. Cell Genet. 8: 759.Google Scholar