Killing, Stress Responses and Mutagenesis Induced in E. Coli by Hydrogen Peroxide

  • Stuart Linn
  • Sherman M. Chin
  • James A. Imlay
Chapter

Abstract

To study DNA damage by oxyradicals and its repair, we have utilized H2O2 toxicity toward E. coli as a model system—the H2O2 because of the relative simplicity of its chemistry, and E. coli because of the accumulated knowledge of its genetics, molecular biology, and DNA enzymology. This report summarizes our most recent biological and chemical observations with this model system.

Keywords

NADH Dehydrogenase Chemical Observation Characteristic Dose Response Oxygen Radical Toxicity H202 Toxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Stuart Linn
    • 1
  • Sherman M. Chin
    • 1
  • James A. Imlay
    • 1
  1. 1.Dept. of BiochemistryUniversity of CaliforniaBerkeleyUSA

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