Killing, Stress Responses and Mutagenesis Induced in E. Coli by Hydrogen Peroxide

  • Stuart Linn
  • Sherman M. Chin
  • James A. Imlay


To study DNA damage by oxyradicals and its repair, we have utilized H2O2 toxicity toward E. coli as a model system—the H2O2 because of the relative simplicity of its chemistry, and E. coli because of the accumulated knowledge of its genetics, molecular biology, and DNA enzymology. This report summarizes our most recent biological and chemical observations with this model system.


NADH Dehydrogenase Chemical Observation Characteristic Dose Response Oxygen Radical Toxicity H202 Toxicity 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Stuart Linn
    • 1
  • Sherman M. Chin
    • 1
  • James A. Imlay
    • 1
  1. 1.Dept. of BiochemistryUniversity of CaliforniaBerkeleyUSA

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