Abstract
The study of the lethal and mutagenic effects of partially-reduced oxygen species such as hydrogen peroxide and superoxide is important for several reasons. Many chemotherapeutic agents generate activated oxygen species during their metabolism1, and these may have an important role in the toxicity of these drugs. Furthermore, these same species have been proposed to have an important role in tumor promotion2 and in the inflammatory response3. Finally, studies with activated oxygen species can provide insights into the cellular effects of γ-radiation4,5, although there is only partial similarity between these damaging agents. The present paper summarizes recent collaborative studies among our laboratories on the mechanisms of hydrogen peroxide-induced lethality in both mammalian and bacterial cells, and compares these results with those obtained in other laboratories.
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Cantoni, O., Brandi, G., Cerutti, P., Meyn, R.E., Murray, D. (1989). Mechanisms of Hydrogen Peroxide Cytotoxicity in Mammalian and Bacterial Cells. In: Castellani, A. (eds) DNA Damage and Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5016-4_29
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DOI: https://doi.org/10.1007/978-1-4757-5016-4_29
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