Abstract
The conversion of DNA lesions into mutations is an active biochemical process. Due to the remarquable efficiency of the error free repair mechanisms only a very small number of DNA lesions will eventually be processed into a mutation. Under normal conditions, less than one percent of DNA lesions give rise to mutations. This makes the biochemical study of the mechanisms involved in mutagenesis very difficult. As a first molecular approach, the study of the mutationnal specificity of a given mutagen will provide important informations concerning the mechanisms that are involved. This is particularly true if the analysis of the mutational specificity can be performed in hosts having altered genotypes for repair and (or) mutagenesis. Bacteria are in this respect the organisms of choice, due to the large number of existing repair, replication and recombination mutants.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
R. P.P. FUCHS, N. SCHWARTZ and M. DAUNE, Nature 294, 657–659 (1981).
N. KOFFEL-SCHWARTZ, J. M. VERDIER, M. BICHARA, A.- M. FREUND, M.P. DAUNE and R.P.P. FUCHS, J. Mol. Biol. 177 33–51 (1984).
M. BICHARA and R.P.P. FUCHS, J. Mol. Biol. 183, 341–351 (1985)
N. S. COHEN,A.C.Y. CHANG and L. HSU, Proc. Natl. Acad. Sci. 69, 2110–14 (1972)
A.M. MAXAM and W. GILBERT, Proc. Natl. Acad. Sci. 75, 560–564 (1977)
R. P.P. FUCHS, J. Mol. Biol. 177, 173–180 (1984).
P. W. DOETSCH, G. L. CHAN and W. A. HASELTINE, Nucl. Acids Res., 13, 3285–3304 (1984)
D. BURNOUF, M.P. DAUNE and R.P.P. FUCHS, Proc. Natl. Acad. Sci 84 3758–62(1987)
R. FUCHS and M. DAUNE, Biochemistry 11, 2659–2666 (1972).
R. P. P. FUCHS, J.-F. LEFEVRE, J. POUYET and M. P. DAUNE, Biochemistry 15,, 3347–3351 (1976).
E. SAGE and M. LENG, Proc. Natl. Acad. Sci. USA 77, 4597–4601 (1980).
E.SAGE and M. LENG, Nucl. Acids Res. 2, 1241–1250 (1981)
R. M. SANTELLA, D. GRUNBERGER, S. BROYDE and B. E. HINGERTY, Nucl. Acids Res. 2, 5459–5467 (1981).
R.M. SANTELLA, D. GRUNBERGER, I.B. WEINSTEIN and A. RICH, Proc. Natl. Acad. Sci. USA 78, 1451–1455 (1981).
R.D.WELLS, J.J. MIGHETTA, J. KLYSIK, J.E. LARSON, S.M. STIRDIVANT and W.ZACHARIAS, J. Biol. Chem. 257, 10166–10171 (1982).
M. P. DAUNE, R.P.P. FUCHS and M. LENG, Natl. Cancer Inst. Monogr. 58, 201–210 (1981).
A. EASTMAN, Biochemistry 2a, 3912–3915 (1986).
N. KOFFEL-SCHWARTZ, G. MAENHAUT-MICHEL and R.P.P. FUCHS, J. Mol. Biol. 193, 651–659 (1987)
A. KORNBERG, Eur. J. Biochem. 137, 377–382 (1983).
V.N. IYER and D. RUPP, Biochem. Biophys. Acta, 228, 117–126 (1971).
R. M. MYERS, L. S. L.RMAN and T. MANIATIS,Science 229, 242–247 (1985)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media New York
About this chapter
Cite this chapter
Fuchs, R.P.P., Bichara, M., Burnouf, D., Koffel-Schwartz, N. (1989). Molecular Mechanisms of Mutagenesis Induced by Chemical Carcinogens and CIS-DDP. In: Castellani, A. (eds) DNA Damage and Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5016-4_20
Download citation
DOI: https://doi.org/10.1007/978-1-4757-5016-4_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-5018-8
Online ISBN: 978-1-4757-5016-4
eBook Packages: Springer Book Archive