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DNA Damage and Repair pp 143–150Cite as

DNA Strand Bias During O6-Methylguanine Mutagenesis

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Abstract

One of the common characteristics of chemical carcinogens and mutagens is their ability to form covalent products with DNA known collectively as adducts. Misreplication or misrepair of DNA adducts can lead to mutations, which in turn can act as the genetic precursors of cancer and other genetic diseases. A problem in contemporary cancer biology has been to discern the mechanisms by which DNA adducts lead to mutations. This problem is complicated by the fact that DNA damaging agents usually form not one, but many DNA lesions. As a result, it is a challenging task to assess the relative contributions of individual DNA adducts to the biological endpoint of mutation.

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Author information

Authors and Affiliations

  1. Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

    John M. Essigmann

Authors
  1. John M. Essigmann
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Editor information

Editors and Affiliations

  1. Department of Environment and Health Protection, ENEA, Rome, Italy

    Amleto Castellani

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© 1989 Springer Science+Business Media New York

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Essigmann, J.M. (1989). DNA Strand Bias During O6-Methylguanine Mutagenesis. In: Castellani, A. (eds) DNA Damage and Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5016-4_16

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  • DOI: https://doi.org/10.1007/978-1-4757-5016-4_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5018-8

  • Online ISBN: 978-1-4757-5016-4

  • eBook Packages: Springer Book Archive

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