Histogenesis and Morphogenesis of the Central Nervous System

  • Marcus Jacobson


Evidence of temporal and spatial regularities in the origin of neurons and glia was extremely difficult to obtain before the advent of the technique of autoradiography following the administration of tritiated thymidine. Information about the time of origin of neurons in the developing nervous system is now obtained with relative ease by injecting pregnant mammals with tritiated thymidine (1–5 µCi per gram body weight) intravenously or into the amniotic fluid, killing the fetuses at various intervals after the injection, and examining their brains autoradiographically.


Purkinje Cell Granule Cell Cerebellar Cortex Mossy Fiber Subventricular Zone 
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Marcus Jacobson
    • 1
  1. 1.The University of Utah College of MedicineSalt Lake CityUSA

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