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The Neutrophil N-Formyl Peptide Receptor: Dynamics of Ligand-Receptor Interactions and Their Relationship to Cellular Responses

  • Chapter
Regulation of Leukocyte Function

Part of the book series: Contemporary Topics in Immunobiology ((CTI,volume 14))

Abstract

The N-formyl peptides, as a class, evoke in neutrophils in vitro an array of responses that mimic the biological functions of these cells in the inflammatory process. Because these peptides can be prepared synthetically, it has been possible to correlate extensively the structure-function relationships of a variety of amino acid sequences in both stimulatory and inhibitory peptides. Moreover,.this diversity in available sequences has permitted the development not only of numerous radiolabeled ligands, but of photoaffinity and fluorescent molecules as well. During the short period since N-formyl-methionyl peptides were first identified as chemoattractants derived from bacteria, the N-formyl peptides receptor has been catapulted into a position of prominence as a model, not only for studies of neutrophil stimulation but for receptor-mediated cell stimulation in general.

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  1. Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California, 92037, USA

    Larry A. Sklar, Algirdas J. Jesaitis & Richard G. Painter

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  1. Larry A. Sklar
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  2. Algirdas J. Jesaitis
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  1. Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, USA

    Ralph Snyderman

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Sklar, L.A., Jesaitis, A.J., Painter, R.G. (1984). The Neutrophil N-Formyl Peptide Receptor: Dynamics of Ligand-Receptor Interactions and Their Relationship to Cellular Responses. In: Snyderman, R. (eds) Regulation of Leukocyte Function. Contemporary Topics in Immunobiology, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4862-8_2

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