Clinical Disorders of Leukocyte Functions

  • Harry R. Hill
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 14)

Abstract

After being questioned by a colleague about my current endeavors with a large number of reprints, reference printouts, and writing pads apparent, I informed him that I was writing another review on clinical abnormalities of phagocyte function. Why write another such review, I was asked, as there are a number of these in the current literature (Gallin, 1981; Lohr and Snyderman, 1981; Hill, 1981a; Gallin et al., 1980; Hill, 1982; Charette and Hill, 1980; Mills and Quie, 1980; Johnston and Newman, 1977; Baehner, 1974; Stossel, 1974). That’s a very good question, which momentarily dimmed my enthusiasm for the project. I believe, however, that the study of phagocyte disorders has turned the corner from that of a purely descriptive, and somewhat inexact, science to one that is applying the rapidly developing tools of cell biology to look into the mechanisms of these fascinating disorders. Thus, cell surface receptors, membrane potential changes, ion fluxes, cyclic nucleotide alterations, protein phosphorylation, microtubule and microfilament function, as well as the various critical metabolic pathways, are being carefully dissected in polymorphonuclear keukocytes (PMNs), monocytes (Mns), and macrophages (Macs). The knowledge gained from these critically important cells in the host-defense mechanism is now spilling over into the study of other cell types, such as those in muscle, liver, bone, and nervous tissue, which are much more difficult to obtain and study. Thus, in many aspects of cell physiology, we—the phagocyte people—are at the forefront of knowledge and scientific investigation.

Keywords

Chronic Granulomatous Disease Respiratory Burst Activity Microbicidal Activity Chronic Granulomatous Disease Patient Leukocyte Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Harry R. Hill
    • 1
  1. 1.Departments of Pathology and PediatricsUniversity of Utah School of MedicineSalt Lake CityUSA

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