Anxiety and Impulse Control in Rats Selectively Bred for Seizure Susceptibility

  • Dan C. Mcintyre
  • Hymie Anisman
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 1)


Behavioral genetic analyses can be a powerful tool in identifying the mechanisms underlying specific pathophysiological states. The most recent approaches in this regard have involved transgenic or knockout mouse models. However, as many pathologies involve multiple gene effects, or an interaction between genes and environment, an alternative approach to assessing pathophysiology involves the use of rat/mouse lines selectively bred to exhibit high or low levels of a given phenotype. These lines can then be used to identify specific neuroanatomical, physiological and/or chemical correlates of the pathology.


Temporal Lobe Epilepsy Reference Memory Inhibitory Avoidance Seizure Susceptibility Perirhinal Cortex 
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  1. Aggleton, J.P., Hunt, P.R., Rawlins, J.N.P. (1986) The effects of hippocampal lesions upon spatial and non-spatial tests of working memory. Behav Brain Res. 19: 133–146.PubMedCrossRefGoogle Scholar
  2. Alemayehu, S., Bergey, G.K., Barry, E., Krumholz, A., Wolf, A., Fleming, C.P., Frear, E.J. (1995) Panic attacks as ictal manifestations of parietal lobe seizures. Epilepsia 36: 824–830.PubMedCrossRefGoogle Scholar
  3. Altshuler, L.L., Devinsky, O., Post, M.D., Theodore, W. (1990) Depression, anxiety, and temporal lobe epilepsy: Laterality of focus and symptoms. Arch Neurol. 47: 284–288.Google Scholar
  4. Anisman, H., Zalcman, S., Shanks, N., Zacharko, R.M. (1991) Multisystem regulation of performance deficits induced by stressors: An animal model of depression. In: A.Boulton, G. Baker, M. Martin-Iverson M. eds. Neuromethods, vol. 19: Animal Models of Psychiatry, II. New Jersey: Humana Press, 1–59.Google Scholar
  5. Anisman, H., Lu, Z.W., Song, C., Kent, P., McIntyre, D.C., Merali, Z. (1997) Influence of psychogenic and neurogenic stressors on endocrine and immune activity: differential effects in fast and slow seizing rat strains. Brain Behav Immun. 11: 63–74.PubMedCrossRefGoogle Scholar
  6. Anisman, H. and Merali, Z. (1999) Anhedonic and anxiogenic effects of cytokine exposure. Adv Exp Med Biol. 461: 199–233.PubMedCrossRefGoogle Scholar
  7. Binnie, C.D. and Marston, D. (1992) Cognitive deficits of interictal discharges. Epilepsia 33: Sl 1-S17. Bolles, R.C. (1970) Species-specific defense reactions and avoidance learning. Psychol. Rev. 77: 32–48.Google Scholar
  8. Corcoran, M.E. and Mason, S.T. (1980) Role of forebrain catecholamines in amygdaloid kindling. Brain Res. 190: 473–484.PubMedCrossRefGoogle Scholar
  9. de Albuquerque, M. and de Campos, C.J. (1993) Epilepsy and anxiety. Arq Neuropsiquiatr. 51: 313–318.PubMedCrossRefGoogle Scholar
  10. DePaulis, A., Helfer, V., Deransart, C., Marescaux, C. (1997) Anxiogenic-like consequences in animal models of complex partial seizures. Neurosci Biobehav Rev. 21: 767–774.PubMedCrossRefGoogle Scholar
  11. Dodrill, C.B. (1992) Interictal cognitive aspects of epilepsy. Epilepsia 33: S7–510.PubMedCrossRefGoogle Scholar
  12. Ettinger, A.B., Weisbrot, D.M., Nolan, E.E., Gadow, K.D., Vitale, S.A., Andiola, M.R., Lenn, N.J., Novak, G.P., and Hermann, B.P. (1998) Symptoms of depression and anxiety in pediatric epilepsy patients. Epilepsia 39: 595–599.PubMedCrossRefGoogle Scholar
  13. Freund, T., Buzsaki, G. (1996) Interneurons of the hippocampus. Hippocampus. 6: 345–474.Google Scholar
  14. Genton, P., Bartolomei, F., Guerrini, R. (1995) Panic attacks mistaken for relapse of epilepsy. Epilepsia 36: 48–51.PubMedCrossRefGoogle Scholar
  15. Helfer, V., Deransart, C., Marescaux, C., DePaulis, A. (1996) Amygdala kindling in the rat: anxiogeniclike consequences. Neuroscience 73: 971–978.PubMedCrossRefGoogle Scholar
  16. Hermann, B.P. (1982) Neuropsychological functioning and psychopathology in children with epilepsy. Epilepsia 23: 545–554.PubMedCrossRefGoogle Scholar
  17. Hermann, B.P. and Whitman, S. (1984) Behavioral and personality correlates of epilepsy: A review, methodological critique, and conceptual model. Psychol Bull. 95: 451–497.PubMedCrossRefGoogle Scholar
  18. Hooper, S.R. and 011ey, J.G. (1996) Psychological comorbidity in adults with learning disabilities. In N. Gregg, C. Hoy and A.F. Gay eds. Adults With Learning Disabilities. The Guilford Press, New York, pp. 162–183.Google Scholar
  19. Kanner, A.M. and Nieto, J.C. (1999) Depressive disorders in epilepsy. Neurology 53: S26 - S32.PubMedCrossRefGoogle Scholar
  20. McIntyre, D.C., Saari, M., and Pappas, B.A. (1979) Potentiation of amygdala kindling in adult or infant rats by injection of 6-hydroxydopamine. Exp. Neurol. 63: 527–544.PubMedCrossRefGoogle Scholar
  21. McIntyre, D.C., Kelly, M.E., Dufresne, C. (1999a) FAST and SLOW amygdala kindling rat strains: comparison of amygdala, hippocampal, piriform and perirhinal cortex kindling. Epilepsy Res., 35: 197–209.PubMedCrossRefGoogle Scholar
  22. McIntyre, D.C., Hutcheon, B., Poulter, M.O. (1999b) Altered GABAA receptor kinetics in the perirhinal cortex of seizure-prone and resistant rats. Soc Neurosci Abstr. 25: 539.Google Scholar
  23. McIntyre, D.C., Kent, P., Hayley, S., Merali, Z., and Anisman, H. (1999c) Influence of psychogenic and neurogenic stressors on neuroendocrine and central monoamine activity in fast and slow kindling rats. Brain Res. 840: 65–74.PubMedCrossRefGoogle Scholar
  24. McIntyre, M., Pritchard, P.B., Lombroso, C.T. (1976) Left and right temporal lobe epileptics: a controlled investigation of some psychological differences. Epilepsia 17: 377–386.PubMedCrossRefGoogle Scholar
  25. McLeod, W.S. and McIntyre, D.C. (1995) The effects of amygdala kindling on T-maze performance in epileptogenetically Fast and Slow kindling rat strains. Soc Neurosci Abstr. 21: 2115.Google Scholar
  26. Mendez, M.F., Cummings, J.L., and Benson, D.F. 1986. Depression in epilepsy. Arch Neurol. 43, 766–770.PubMedCrossRefGoogle Scholar
  27. Merali, Z., Michaud, D., Kent, P., McIntyre, D.C., McIntosh, J., Anisman, H. (1997) Effects of psychological (ferret exposure) and restraint stressors on amygdalar CRF release and endocrine responses in two differentially stress-sensitive rat strains. Soc Neurosci Abst 23: 1077.Google Scholar
  28. Michaud, D., McIntyre, D.C., Anisman, H, and Merali, Z. (1999) Rat strains with high versus low sexual reactivity: Behavioral and lateralized amygdala CRH responses of males. Soc Neurosci Abst. 25: 346.Google Scholar
  29. Mohapel, P. and McIntyre, D.C. (1998) Amygdala kindling-resistant (SLOW) or -prone ( FAST) rat strains show differential fear responses. Behav Neurosci. 112: 1402–1413.CrossRefGoogle Scholar
  30. Poulter, M.O., Brown, L.A., Tynan, S., Willick, G., William, R., McIntyre, D.C. (1999) Differential expression of al, a2, a3, and a5 GABAA receptor subunits in seizure-prone and seizure-resistant rat models of temporal lobe epilepsy. J Neurosci. 19: 4654–4661.PubMedGoogle Scholar
  31. Racine, R.J. (1972) Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr Clin Neurophysiol. 32: 281–294.Google Scholar
  32. Racine, R.J., Steingart, M., and McIntyre, D.C. (1999) Development of kindling-prone and kindling-resistant rats: selective breeding and electrophysiological studies. Epilepsy Res. 35: 183–195.PubMedCrossRefGoogle Scholar
  33. Roberston, M.M., Trimble, M.R., Townsend, H.R.A. (1987) Phenomenology of depression in epilepsy. Epilepsia, 28: 364–368.CrossRefGoogle Scholar
  34. Shettleworth, S.J. (1972) Constraints on learning. In D.S. Lehrman, R.A. Hinde, E. Shaw, eds. Advances in the Study of Behavior. Academic Press, New York.Google Scholar
  35. Traub, R.D., Whittington, M.A., Coiling, S.B., Buzsaki, G., and Jefferys, J.G. (1996) Analysis of gamma rhythms in the rat hippocampus in vitro and in vivo. J Physiol. 493: 471–484.PubMedGoogle Scholar
  36. Traub, R.D., Whittington, M.A., Stanford, I.M., and Jefferys, J.G. (1996) A mechanism for generation of long-range synchronous fast oscillations in the cortex. Nature 383: 621–624.PubMedCrossRefGoogle Scholar
  37. Traub, R.D., Spruston, N., Soltesz, I., Konnerth, A., Whittington, M.A., and Jefferys, J.R. (1998) Gamma-frequency oscillations: a neuronal popultation phenomenon, regulated by synaptic and intrinsic cellular process, and inducing synaptic plasticity. Prog Neurobiol. 55: 563–575.PubMedCrossRefGoogle Scholar
  38. Weilburg, J.B., Bear, D.M., Sachs, G. (1987) Three patients with concomitant panic attacks and seizure disorder: possible clues to the neurology of anxiety. Am J Psychiat. 144: 1053–1056.PubMedGoogle Scholar
  39. Whishaw, I. Q. (1985) Formation of a place learning-set by the rat: a new paradigm for neurobehavioral studies. Physiol Behay. 35: 139–143.CrossRefGoogle Scholar

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© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Dan C. Mcintyre
  • Hymie Anisman

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