Emergence of Ptsd-Type Reactivity in Sprague-Dawley Rats Following Prenatal Gamma Irradiation

  • Matti Mintz
  • Michael Myslobodsky
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 1)


Posttraumatic Stress Disorder (PTSD) is believed to be precipitated by stressors which are markedly distressing to almost anyone (DSM-III), so that the major experimental paradigms relevant for modeling PTSD have emphasized the necessity of traumatic history for development of conditioned fear. By contrast, the necessity of an innate (unconditioned) fear as a prerequisite for PTSD has not received a proper hearing. The potential of the traumatic precipitant is somewhat reduced by the fact that not everyone will have gone to pieces in conditions of severe stress whereas others are expected to develop PTSD following relatively ‘mild’ psychological trauma (Foy et al., 1987). Lord Taylor (1978) noticed that during WWII, only a fraction of the civil population (about 10%) were afflicted in the bombed cities in England. Somewhat apologetically he called them “the psychopathic tenth.” This variation in response to stress is in keeping with an old conviction that the syndrome “depends not only upon the kind of injury, but upon the kind of brain” (Symonds, 1937, p. 464).


Posttraumatic Stress Disorder Startle Response Prepulse Inhibition Acoustic Startle Startle Habituation 
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  • Matti Mintz
  • Michael Myslobodsky

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