Animal Models of Bipolar Disorder: From a Single Episode to Progressive Cycling Models

  • Haim Einat
  • Ora Kofman
  • Robert H. Belmaker
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 1)


Animal models of psychopathology are divided into three major groups: heuristic models that assume a common underlying mechanism between a superficially different animal behavior and a particular human pathology; theory-based evidential models, which place emphasis on a common feature (etiological or behavioral) of both the model and the pathology; representative models involving generalization of a well-validated behavior to model the pathology (Overmier and Patterson, 1988; Ursin and Murison, 1986). The choice of a particular model for research will depend ultimately on the extent to which the etiology of the disorder is known, the specificity and efficacy of the pharmacological treatments available, and the facility with which the pathological behaviors can be mimicked in laboratory animals.


Bipolar Disorder Sleep Deprivation Conditioned Place Preference Behavioral Sensitization Chronic Mild Unpredictable Stress 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Haim Einat
  • Ora Kofman
  • Robert H. Belmaker

There are no affiliations available

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