Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Parathyroid Hormone

  • Chapter
Contemporary Endocrinology

Abstract

Recent published work on parathyroid hormone (PTH) constitutes a record of steady progress along mostly familiar lines. Aspects of hormone synthesis and kinetics, effects on renal physiology, and the vitamin D-PTH interaction have become much clearer. A new classification of hypercalciurias and the role of PTH in their production has been presented. Radiation-induced hyperparathyroidism now seems an established entity, and hypertension secondary to hyperparathyroidism may be on the way to becoming one.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Habener, J.F., Amherdt, M., and Orci, L., 1977, Subcellular organelles involved in the conversion of biosynthetic precursors of parathyroid hormone, Trans. Assoc. Amer. Phys. 90: 366–379.

    CAS  Google Scholar 

  2. Habener, J.F., Chang, H.T., and Potts, J.T., Jr., 1977, Enzymic processing of proparathyroid hormone by cell-free extracts of parathyroid glands, Biochemistry 16: 3910–3917.

    PubMed  CAS  Google Scholar 

  3. MacGregor, R.R., Chu, L.L.H., and Cohn, D.V., 1976, Conversion of proparathyroid hormone to parathyroid hormone by a paniculate enzyme of the parathyroid gland, J. Biol. Chem. 251: 6711–6716.

    PubMed  CAS  Google Scholar 

  4. MacGregor, R.R., Hamilton, J.W., and Cohn, D.V., 1975, The by-pass of tissue hormone stores during the secretion of newly synthesized parathyroid hormone, Endocrinology 97: 178–188.

    PubMed  CAS  Google Scholar 

  5. Thiele, J., 1977, Human parathyroid gland: A freeze fracture and thin section study, Curr. Top. Pathol. 65: 31–80.

    PubMed  CAS  Google Scholar 

  6. Chanard, J., Black, R., Purkerson, M., Lewis, J., Klahr, S., and Slatopolsky, E., 1977, The effects of colchicine and vinblastine on parathyroid hormone secretion in the rat, Endocrinology 101: 1792–1800.

    PubMed  CAS  Google Scholar 

  7. Chertow, B.S., Manke, D.J., Williams, G.A., Baker, G.R., Hargis, G.K., and Buschmann, R.J., 1977, Secretory and ultrastructural responses of hyperfunctioning human parathyroid tissues to varying calcium concentration and vinblastine, Lab. Invest. 36: 198–205.

    PubMed  CAS  Google Scholar 

  8. Segre, G.V., Niall, H.D., Habener, J.F., and Potts, J.T., Jr., 1974, Metabolism of parathyroid hormone: Physiologic and clinical significance, Am. J. Med. 56: 774–784.

    PubMed  CAS  Google Scholar 

  9. Segre, G.V., D’Amour, P., and Potts, J.T., Jr., 1976, Metabolism of radioiodinated bovine parathyroid hormone in the rat, Endocrinology 99: 1645–1652.

    PubMed  CAS  Google Scholar 

  10. Hunziker, W.H., Blum, J.W., and Fischer, J.A., 1977, Plasma kinetics of exogenous bovine parathyroid hormone in calves, Pfluegers. Arch. 371: 185–192.

    CAS  Google Scholar 

  11. Papapoulos, S.E., Hendy, G.N., Tomlinson, S., Lewin, I.G., and O’Riordan, J.L.H., 1977, Clearance of exogenous parathyroid hormone in normal and uraemic man, Clin. Endocrinol. 7: 211–225.

    CAS  Google Scholar 

  12. Martin, K., Hruska, K., Greenwalt, A., Klahr, A., and Slatopolsky, E., 1976, Selective uptake of intact parathyroid hormone by the liver: Differences between hepatic and renal uptake, J. Clin. Invest. 58: 781–788.

    PubMed  CAS  Google Scholar 

  13. Hruska, K.A., Martin, K., Mennes, P., Greenwalt, A., Anderson, C., Klahr, S., and Slatopolsky, E., 1977, Degradation of parathyroid hormone and fragment production by the isolated perfused dog kidney: The effect of glomerular filtration rate and perfusate Ca++ concentrations, J. Clin. Invest. 60: 501–510.

    PubMed  CAS  Google Scholar 

  14. Martin, K.J., Hruska, K.A., Lewis, J., Anderson, C., and Slatopolsky, E., 1977, The renal handling of parathyroid hormone: Role of peritubular uptake and glomerular filtration, J. Clin. Invest. 60: 808–814.

    PubMed  CAS  Google Scholar 

  15. Zull, J.E., Malbon, C.C., and Chuang, J., 1977, Binding of tritiated bovine parathyroid hormone to plasma membranes from bovine kidney cortex, J. Biol. Chem. 252: 1071–1078.

    PubMed  CAS  Google Scholar 

  16. Marcus, R., and Aurbach, G.D., 1971, Adenyl cyclase from renal cortex, Biochim. Biophys. Acta 242: 410–421.

    PubMed  CAS  Google Scholar 

  17. Canterbury, J.M., Bricker, L.A., Levey, G.S., Kozlovskis, P.L., Ruiz, E., Zull, J.E., and Reiss, E., 1975, Metabolism of bovine parathyroid hormone: Immunological and biological characteristics of fragments generated by liver perfusion, J. Clin. Invest. 55: 1245–1253.

    PubMed  CAS  Google Scholar 

  18. Malbon, C.C., and Zull, J.E., 1977, Studies of binding of parathyroid hormone to a detergent-dispersed preparation from bovine kidney cortex plasma membranes, J. Biol. Chem. 252: 1079–1083.

    PubMed  CAS  Google Scholar 

  19. Rosenblatt, M., and Potts, J.T., Jr., 1977, Design and synthesis of parathyroid hormone analogues of enhanced biological activity, Endocrine Res. Comm. 4: 115–133.

    CAS  Google Scholar 

  20. Dennis, V.W., Bello-Reuss, E., and Robinson, R.R., 1977, Response of phosphate transport to parathyroid hormone in segments of rabbit nephron, Am. J. Physiol. 233: F29–F38.

    PubMed  CAS  Google Scholar 

  21. Knox, F.G., Greger, R.F., Lang, F.C., and Marchand, G.R., 1977, Renal handling of phosphate: Update, in: Advances in Phosphate Metabolism, Vol. 81 (S.G. Massry and E. Ritz, eds.), pp. 3–14, Plenum Press, New York.

    Google Scholar 

  22. Knox, F.G., Osswald, H., Marchand, G.R., Marchand, W.S., Spielman, J.A., Haas, T., Berndt, T., and Youngberg, S.P., 1977, Phosphate transport along the nephron, Am. J. Physiol. 233: F261–F268.

    PubMed  CAS  Google Scholar 

  23. Ellsworth, R., and Nicholson, W.M., 1935, Further observations upon the changes in the electrolytes of the urine following the injection of parathyroid extract, J. Clin. Invest. 14: 823–827.

    PubMed  CAS  Google Scholar 

  24. Kleeman, C.R., and Cooke, R.E., 1951, The acute effects of parathyroid hormone on the metabolism of endogenous phosphate, J. Lab. Clin. Med. 38: 112–127.

    PubMed  CAS  Google Scholar 

  25. Nordin, B.E.C., 1960, The effect of intravenous parathyroid extract on urinary pH, bicarbonate and electrolyte excretion, Clin. Sci. 19: 311–319.

    PubMed  CAS  Google Scholar 

  26. Hellman, D.E., Au, W.Y.W., and Bartter, F.C., 1965, Evidence for a direct effect of parathyroid hormone on urinary acidification, Am. J. Physiol. 209: 643–650.

    PubMed  CAS  Google Scholar 

  27. Beck, L.H., and Goldberg, M., 1973, Effects of acetazolamide and parathyroidectomy on renal transport of sodium, calcium and phosphate, Am. J. Physiol. 224: 1136–1142.

    PubMed  CAS  Google Scholar 

  28. Beck, N., Kim, K.S., Wolak, M., and Davis, B.B., 1975, Inhibition of carbonic anhydrase by parathyroid hormone and cyclic AMP in rat renal cortex in vitro, J. Clin. Invest. 55: 149–156.

    PubMed  CAS  Google Scholar 

  29. Uchikawa, T., Borle, A.B., and Midgett, R.J., 1976, Parathyroid hormone and phosphaturia, Calcif. Tissue Res. 21:(Suppl.) 284–287.

    PubMed  Google Scholar 

  30. Dennis, V.W., 1976, Influence of bicarbonate on parathyroid hormone-induced changes in fluid absorption by the proximal tubule, Kidney Int. 10: 373–380.

    PubMed  CAS  Google Scholar 

  31. Knox, F.G., Haas, J.A., and Lechene, C.P., 1976, Effect of parathyroid hormone on phosphate reabsorption in the presence of acetazolamide, Kidney Int. 10: 216–220.

    PubMed  CAS  Google Scholar 

  32. Nascimento, L., Rademacher, D.R., Arruda, J.A.L., and Kurtzman, N.A., 1977, Effect of acetazolamide and parathyroid hormone on HCO3 and PO4 excretion, J. Pharmacol. Exp. Ther. 201: 243–250.

    PubMed  CAS  Google Scholar 

  33. Arruda, J.A.L., Nascimento, L., Westenfelder, C., and Kurtzman, N.A., 1977, Effect of parathyroid hormone on urinary acidification, Am. J. Physiol. 232: F429–F433.

    PubMed  CAS  Google Scholar 

  34. Aurbach, H.D., Brown, E.M., and Marx, S.J., 1977, Receptors and cyclic nucleotides in secretion and action of parathyroid hormone, Calcif. Tissue Res. 22: (Suppl.) 117–126.

    PubMed  Google Scholar 

  35. Bijvoet, O.L.M., 1976, The importance of the kidney in phosphate homeostasis, in: Phosphate Metabolism: Kidney and Bone (L. Avioli, P. Bordier, H. Fleisch, S.G. Massry, and E. Slatopolsky, eds.), pp. 421–474, Nouvelle Imprimerie Fournie, Toulouse, France.

    Google Scholar 

  36. Lau, K., Agus, Z.S., Goldberg, M., and Goldfarb, S., 1977, Chronic phosphate depletion: Changes in segmental calcium and phosphate reabsorption, Kidney Int. 12: 458.

    Google Scholar 

  37. Goldfarb, S., Westby, G.R., Goldberg, M., and Agus, Z.S., 1977, Renal tubular effects of chronic phosphate depletion, J. Clin. Invest. 59: 770–779.

    PubMed  CAS  Google Scholar 

  38. Costanzo, L.S., and Windhager, E.E., 1977, In vivo microperfusion study of calcium (Ca) and sodium (Na) transport in the distal convoluted tubule, Kidney Int. 12: 456.

    Google Scholar 

  39. Bonjour, J.P., Preston, C., and Fleisch, H., 1977, Effect of 1,25-dihydroxy-vitamin D3 on the renal handling of P1 in thyroparathyroidectomized rats, J. Clin. Invest. 60: 1419–1428.

    PubMed  CAS  Google Scholar 

  40. Sutton, R.A.L., and Dirks, J.H., 1977, Renal handling of calcium: Overview, in: Advances in Phosphate Metabolism, Vol. 81 (S.G. Massry and E. Ritz, eds.), pp. 15–27, Plenum Press, New York.

    Google Scholar 

  41. Chabardès, D., Imbert, M., Clique, A., Montégut, M., and Morel, F., 1975, PTH-sensitive adenyl cyclase activity in different segments of the rabbit nephron, Pfluegers Arch. 354: 229–239.

    Google Scholar 

  42. Agus, Z.S., Chiu, P.J.S., and Goldberg, M., 1977, Regulation of urinary calcium excretion in the rat, Am. J. Physiol. 232: F545–549.

    PubMed  CAS  Google Scholar 

  43. Humes, H.D., Ichikawa, I., Troy, J.L., Anderson, A.J., and Brenner, B.M., 1977, Influence of calcium on the determinants of glomerular ultra-filtration, Trans. Assoc. Am. Physicians 90: 228–238.

    PubMed  CAS  Google Scholar 

  44. Ichikawa, I., Humes, H.D., and Brenner, B.M., 1977, Evidence for a glomerular action of parathormone in the rat, Trans. Assoc. Am. Physicians 90: 248–256.

    PubMed  CAS  Google Scholar 

  45. Gerblich, A.A., Genuth, S.M., and Haddad, J.G., Jr., 1977, A case of idiopathic hypoparathyroidism and dietary vitamin D deficiency: The requirement for calcium and vitamin D for bone, but not renal responsiveness to PTH, J. Clin. Endocrinol. Metab. 44: 507–513.

    PubMed  CAS  Google Scholar 

  46. Madsen, S., Ølgaard, K., and Ladefoged, J., 1976, 1-Alpha-hydroxycholecalciferol-induced changes in the renal handling of phosphate and the serum parathyroid hormone level, Acta Med. Scand. 200: 351–354.

    PubMed  CAS  Google Scholar 

  47. Madsen, S., Ølgaard, K., and Thaysen, J.H., 1977, The effect of 1-α-hydroxycholecalciferol on the renal handling of phosphate in parathyroidectomized man, Acta Med. Scand. 202: 23–26.

    PubMed  CAS  Google Scholar 

  48. Luben, R.A., Wong, G.L., and Cohn, D.V., 1976, Biochemical characterization with parathormone and calcitonin of isolated bone cells: Provisional identification of osteoclasts and osteoblasts, Endocrinology 99: 526–534.

    PubMed  CAS  Google Scholar 

  49. Wong, G.L., Luben, R.A., and Cohn, D.V., 1977, 1,25-Dihydroxycholecalciferol and parathormone: Effects on isolated osteoclast-like and osteoblast-like cells, Science 197: 663–665.

    PubMed  CAS  Google Scholar 

  50. Scully, R.E., Galdabini, J.J., and McNeely, B.U., 1978, Case records of the Massachusetts General Hospital: Weekly clinicopathological exercises, case 4, N. Engl. J. Med. 298: 266–274.

    Google Scholar 

  51. Rizzoli, R., Fleisch, H., and Bonjour, J.P., 1977, Effect of thyroparathyroidectomy on calcium metabolism in rats: Role of 1,25-dihydroxyvitamin D3, Am. J. Physiol. 223: E160–E164.

    Google Scholar 

  52. Jensen, P.S., and Kliger, A.S., 1977, Early radiographic manifestations of secondary hyperparathyroidism associated with chronic renal disease, Radiology 125: 645–652.

    PubMed  CAS  Google Scholar 

  53. Herrmann-Erlee, M.P.M., Hekkelman, J.W., Heersche, J.N.M., and Nijweide, P.J., 1975, The role of Ca2+ and cyclic AMP in the action of parathyroid hormone on embryonic bone in vitro, J. Endocrinol. 64: 69P.

    PubMed  CAS  Google Scholar 

  54. Drüeke, T., Bordier, P.J., Man, N.K., Jungers, P., and Marie, P., 1977, Effects of high dialysate calcium concentration on bone remodeling, serum biochemistry, and parathyroid hormone in patients with renal osteodystrophy, Kidney Int. 11: 267–274.

    PubMed  Google Scholar 

  55. Wecksler, W.R., Henry, H.L., and Norman, A.W., 1977, Studies on the mode of action of calciferol: Subcellular localization of 1,25-dihydroxyvitamin D3 in chicken parathyroid glands, Arch. Biochem. Biophys. 183: 168–175.

    PubMed  CAS  Google Scholar 

  56. Altenähr, E., Dietel, M., Dorn, G., and Montz, R., 1977, The effect of 1,25-dihydroxycholecalciferol on the parathyroid hormone secretion of porcine parathyroid glands and human parathyroid adenomas in vitro, Acta Endocrinol. 86: 533–538.

    PubMed  Google Scholar 

  57. Llach, F., Coburn, J.W., Brickman, A.S., Kurokawa, K., Norman, A.W., Canterbury, J.M., and Reiss, E., 1977, Acute actions of 1,25-dihydroxyvitamin D3 in normal man: Effect on calcium and parathyroid status, J. Clin. Endocrinol. Metab. 44: 1054–1060.

    PubMed  CAS  Google Scholar 

  58. Arieff, A.I., and Massry, S.G., 1974, Calcium metabolism of brain in acute renal failure: Effects of uremia, hemodialysis, and parathyroid hormone, J. Clin. Invest. 53: 387–392.

    PubMed  CAS  Google Scholar 

  59. Guisado, R., Arieff, A.I., and Massry, S.G., 1975, Changes in the electroencephalogram in acute uremia: Effects of parathyroid hormone and brain electrolytes, J. Clin. Invest. 55: 738–745.

    PubMed  CAS  Google Scholar 

  60. Cogan, M., Covey, C., Arieff, A., Lazarowitz, V., Wisniewski, A., and Clark, O., 1977, Effects of hyperparathyroidism on the central nervous system, Kidney Int. 12: 455.

    Google Scholar 

  61. Carman, J.S., Post, R.M., Goodwin, F.K., and Bunney, W.E., Jr., 1977, Calcium and electroconvulsive therapy of severe depressive illness, Biol. Psychiatry 12: 5–17.

    PubMed  CAS  Google Scholar 

  62. Massry, S.G., 1977, Is parathyroid hormone a uremic toxin?, Nephron 19: 125–130.

    PubMed  CAS  Google Scholar 

  63. Ball, J.H., Butkus, D.E., and Madison, D.S., 1977, Effect of subtotal parathyroidectomy on dialysis dementia, Nephron 18: 151–155.

    PubMed  CAS  Google Scholar 

  64. Dousa, T.P., Barnes, L.D., Ong, S.H., and Steiner, A.L., 1977, Immunohistochemical localization of 3′:5′-cyclic AMP and 3′:5′-cyclic GMP in rat renal cortex: Effect of parathyroid hormone, Proc. Natl. Acad. Sci. U.S.A. 74: 3569–3573.

    PubMed  CAS  Google Scholar 

  65. Davidovitch, Z., Montgomery, P.C., and Shanfeld, J.L., 1977, Cellular localization and concentration of bone cyclic nucleotides in response to acute PTE administration, Calcif. Tissue Res. 24: 81–91.

    PubMed  CAS  Google Scholar 

  66. Horiuchi, N., Suda, T., Takahashi, H., Shimazawa, E., and Ogata, E., 1977, In vivo evidence for the intermediary role of 3′,5′-cyclic AMP in parathyroid hormone-induced stimulation of 1α,25-dihydroxyvitamin D3 synthesis in rats, Endocrinology 101: 969–974.

    PubMed  CAS  Google Scholar 

  67. Kurokawa, K., Lenchner, G., and Massry, S.G., 1977, Interaction between parathyroid hormone and catecholamines on renal cortical cyclic AMP, Nephron 18: 60–67.

    PubMed  CAS  Google Scholar 

  68. Ong, S.H., Whitley, T.H., Stowe, N.W., and Steiner, A.L., 1975, Immunohistochemical localization of 3′:5′-cyclic AMP and 3′:5′-cyclic GMP in rat liver, intestine, and testis, Proc. Natl. Acad. Sci. U.S.A. 72: 2022–2026.

    PubMed  CAS  Google Scholar 

  69. Steiner, A.L., Ong, S.H., and Wedner, H.J., 1976, Cyclic nucleotide immunohistochemistry, Adv. Cyclic Nucleotide Res. 7: 115–155.

    PubMed  CAS  Google Scholar 

  70. Davidovitch, Z., Montgomery, P.C., and Shanfeld, J.L., 1977, Guanosine 3′:5′-monophosphate in bone: Microscopic visualization by an immunohistochemical technique, Calcif. Tissue Res. 24: 73–79.

    PubMed  CAS  Google Scholar 

  71. Spiegel, A.M., and Aurbach, G.D., 1974, Binding of 5′-guanylyl-imidodiphosphate to turkey erythrocyte membranes and effects of β-adrenergic activated adenylate cyclase, J. Biol. Chem. 249: 7630–7636.

    PubMed  CAS  Google Scholar 

  72. Rodbell, M., Lin, M.C., Salomon, Y., Londos, C., Harwood, J.P., Martin, B.R., Rendell, M., and Berman, M., 1974, The role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: Evidence for multi-site transition states, Acta Endocrinol. 77(Suppl. 191): 11–37.

    CAS  Google Scholar 

  73. Schramm, M., and Rodbell, M., 1975, A persistent active state of the adenylate cyclase system produced by the combined actions of isoproterenol and guanylyl-imidodiphosphate in frog erythrocyte membranes, J. Biol. Chem. 250: 2232–2237.

    PubMed  CAS  Google Scholar 

  74. Hunt, N.H., Martin, T.J., Michelangeli, V.P., and Eisman, J.A., 1976, Effect of guanyl nucleotides on parathyroid hormone-responsive adenylate cyclase in chick kidney, J. Endocrinol. 69: 401–412.

    PubMed  CAS  Google Scholar 

  75. Michelangeli, V.P., Hunt, N.H., and Martin, T.J., 1977, States of activation of chick kidney adenylate cyclase induced by parathyroid hormone and guanyl nucleotides, J. Endocrinol. 72: 69–79.

    CAS  Google Scholar 

  76. Werner, S., and Löw, H., 1977, Urinary excretion of cyclic AMP and cyclic GMP in primary hyperparathyroidism with reference to clinical signs and symptoms, Horm. Metab. Res. 9: 332–336.

    PubMed  CAS  Google Scholar 

  77. Streeto, J.M., 1969, Renal cortical adenyl cyclase: Effect of parathyroid hormone and calcium, Metabolism 18: 968–973.

    PubMed  CAS  Google Scholar 

  78. Popovtzer, M.M., Flis, R.S., Mehandru, S.K., and Blum, M., 1977, Effect of divalent cation ionophore (A 23187) on renal handling of phosphorus, Kidney Int. 12: 164–171.

    PubMed  CAS  Google Scholar 

  79. Rasmussen, H., and Goodman, D.B.P., 1977, Relationships between calcium and cyclic nucleotides in cell activation, Physiol. Rev. 57: 421–509.

    PubMed  CAS  Google Scholar 

  80. Habener, J.F., Kemper, B., and Potts, J.T., Jr., 1975, Calcium-dependent intracellular degradation of parathyroid hormone: A possible mechanism for the regulation of hormone stores, Endocrinology 97: 431–441.

    PubMed  CAS  Google Scholar 

  81. Habener, J.F., Stevens, T.D., Ravazzola, M., Orci, L., and Potts, J.T., Jr., 1977, Effects of calcium ionophores on the synthesis and release of parathyroid hormone, Endocrinology 101: 1524–1537.

    PubMed  CAS  Google Scholar 

  82. Brown, E.M., Hurwitz, S., Woodard, C.J., and Aurbach, G.D., 1977, Direct identification of beta-adrenergic receptors on isolated bovine parathyroid cells, Endocrinology 100: 1703–1709.

    PubMed  CAS  Google Scholar 

  83. Brown, E.M., Hurwitz, S., and Aurbach, G.D., 1977, Beta-adrenergic stimulation of cyclic AMP content and parathyroid hormone release from isolated bovine parathyroid cells, Endocrinology 100: 1696–1702.

    PubMed  CAS  Google Scholar 

  84. Brown, E.M., Carroll, R.J., and Aurbach, G.D., 1977, Dopaminergic stimulation of cyclic AMP accumulation and parathyroid hormone release from dispersed bovine parathyroid cells, Proc. Natl. Acad. Sci. U.S.A. 74: 4210–4213.

    PubMed  CAS  Google Scholar 

  85. Araki, N., Nagata, N., and Kimura, N., 1977, Effects of parathyroid hormone and prostaglandin E1 in vitro on release of cyclic AMP from kidney cortical tissue, Endocrinol. Jpn. 24: 581–587.

    CAS  Google Scholar 

  86. Habener, J.F., 1976, New concepts in the formation, regulation of release, and metabolism of parathyroid hormone, in: Polypeptide Hormones: Molecular and Cellular Aspects, pp. 197–224, Elsevier/Excerpta Medica, Amsterdam and New York.

    Google Scholar 

  87. Birnbaumer, M.E., Schneider, A.B., Palmer, D., Hanley, D.A., and Sherwood, L.M., 1977, Secretion of parathyroid hormone by abnormal human parathyroid glands in vitro, J. Clin. Endocrinol. Metab. 45: 105–113.

    PubMed  CAS  Google Scholar 

  88. Dietel, M., Dorn, G., Montz, R., and Altenähr, E., 1977, The effect of calcium and dibutyryl-cAMP on the secretion of parathyroid hormone by human parathyroid adenomas in organ culture, Acta Endocrinol. 85: 541–547.

    PubMed  CAS  Google Scholar 

  89. Bouillon, R., and De Moor, P., 1977, Parathyroid hormone secretion in primary hyperparathyroidism, J. Clin. Endocrinol. Metab. 45: 261–269.

    PubMed  CAS  Google Scholar 

  90. Monchik, J.M., Wray, H.L., Schaaf, M., and Earll, J.M., 1977, Nonautonomy of parathyroid hormone and urinary cyclic AMP in primary hyperparathyroidism, Am. J. Surg. 133: 498–505.

    PubMed  CAS  Google Scholar 

  91. Badder, E.M., Graham, W.P., III, and Harrison, T.S., 1977, Functional insignificance of microscopic parathyroid hyperplasia, Surg. Gynecol. Obstet. 145: 863–868.

    PubMed  CAS  Google Scholar 

  92. Fialkow, P.J., Jackson, C.E., Block, M.A., and Greenawald, K.A., 1977, Multicellular origins of parathyroid “adenomas,” N. Engl. J. Med. 297: 696–698.

    PubMed  CAS  Google Scholar 

  93. Dinnen, J.S., Greenwood, R.H., Jones, J.H., Walker, D.A., and Williams, E.D., 1977, Parathyroid carcinoma in familial hyperparathyroidism, J. Clin. Pathol. 30: 966–975.

    PubMed  CAS  Google Scholar 

  94. Okerlund, M.D., Beckmann, A., Galante, M., and Hunt, T., 1978, Radiation-induced parathyroid tumors following head and neck radiation in childhood, Clin. Res. 26: 191A.

    Google Scholar 

  95. Tisell, L.-E., Hannson, G., Lindberg, S., and Ragnhult, I., 1977, Hyperparathyroidism in persons treated with X-rays for tuberculous cervical adenitis, Cancer 40: 846–854.

    PubMed  CAS  Google Scholar 

  96. Pritchard, M.H., and Jessop, J.D., 1977, Chondrocalcinosis in primary hyperparathyroidism, Ann. Rheum. Dis. 36: 146–151.

    PubMed  CAS  Google Scholar 

  97. Rollinson, R.D., and Gilligan, B.S., 1977, Primary hyperparathyroidism presenting as a proximal myopathy, Aust. N.Z.J. Med. 7: 420–421.

    PubMed  CAS  Google Scholar 

  98. Broadus, A.E., Hanson, T.A.S., Bartter, F.C., and Walton, J., 1977, Primary hyperparathyroidism presenting as anticonvulsant-induced osteomalacia, Am. J. Med. 63: 298–305.

    PubMed  CAS  Google Scholar 

  99. Ljunghall, S., Hedstrand, H., Hellsing, K., and Wibell, L., 1977, Calcium, phosphate and albumin in serum, Acta Med. Scand. 201: 23–30.

    PubMed  CAS  Google Scholar 

  100. Christensson, T., Hellstrom, K., and Wengle, B., 1977, Hypercalcemia and primary hyperparathyroidism, Arch. Intern. Med. 137: 1138–1142.

    PubMed  CAS  Google Scholar 

  101. Christensson, T., Hellstrom, K., and Wengle, B., 1977, Blood pressure in subjects with hypercalcemia and primary hyperparathyroidism detected in a health screening programme, Eur. J. Clin. Invest. 7: 109–113.

    PubMed  CAS  Google Scholar 

  102. Boxer, M., Ellman, L., Geller, R., and Wang, C.-A., 1977, Anemia in primary hyperparathyroidism, Arch. Intern. Med. 137: 588–590.

    PubMed  CAS  Google Scholar 

  103. Levi, J., Bessler, H., Hirsch, I., and Djaldetti, M., 1977, The inhibitory effect of parathyroid hormone (PTH) on RNA and heme synthesis, Kidney Int. 12: 527.

    Google Scholar 

  104. Coffey, R.J., Lee, T.C., and Canary, J.J., 1977, The surgical treatment of primary hyperparathyroidism: A 20 year experience, Ann. Surg. 185: 518–523.

    PubMed  CAS  Google Scholar 

  105. Gray, R.W., Wilz, D.R., Caldas, A.E., and Lemann, J., Jr., 1977, The importance of phosphate in regulating plasma 1,25-(OH)2-vitamin D levels in humans: Studies in healthy subjects, in calcium-stone formers and in patients with primary hyperparathyroidism, J. Clin. Endocrinol. Metab. 45: 299–306.

    PubMed  CAS  Google Scholar 

  106. Kaplan, R.A., Haussler, M.R., Deftos, L.J., Bone, H., and Pak, C.Y.C., 1977, The role of 1α,25-dihydroxyvitamin D in the mediation of intestinal hyperabsorption of calcium in primary hyperparathyroidism and absorptive hypercalciuria, J. Clin. Invest. 59: 756–760.

    PubMed  CAS  Google Scholar 

  107. Shen, F.H., Baylink, D.J., Nielsen, R.L., Sherrard, D.J., Ivey, J.L., and Haussier, M.R., 1977, Increased serum 1,25-dihydroxyvitamin D in idiopathic hypercalciuria, J. Lab. Clin. Med. 90: 955–962.

    PubMed  CAS  Google Scholar 

  108. Transbøl, I., 1977, On the diagnosis of so-called normocalcemic hyperparathyroidism, Acta Med. Scand. 202: 481–487.

    PubMed  Google Scholar 

  109. Bordier, P., Ryckewart, A., Gueris, J., and Rasmussen, H., 1977, On the pathogenesis of idiopathic hypercalciuria, Am. J. Med. 63: 398–409.

    PubMed  CAS  Google Scholar 

  110. Shaw, J.W., Oldham, S.B., Rosoff, L., Bethune, J.E., and Fichman, M.P., 1977, Urinary cyclic AMP analyzed as a function of the serum calcium and parathyroid hormone in the differential diagnosis of hypercalcemia, J. Clin. Invest. 59: 14–21.

    PubMed  CAS  Google Scholar 

  111. Broadus, A.E., Mahaffey, J.E., Bartter, F.C., and Neer, R.M., 1977, Nephrogenous cyclic adenosine monophosphate as a parathyroid function test, J. Clin. Invest. 60: 771–783.

    PubMed  CAS  Google Scholar 

  112. Walker, D.A., Davies, S.J., Siddle, K., and Woodhead, J.S., 1977, Control of renal tubular phosphate reabsorption by parathyroid hormone in man, Clin. Sci. Mol. Med. 53: 431–438.

    PubMed  CAS  Google Scholar 

  113. Pena, J.C., Guerrero, J., Erbessd, M.L., Quiroz, S., and Jaime Herrera, A., 1977, Total dietary phosphorus deprivation (TPD) in normal subjects (NS) and in patients with hyper (HP) and hypoparathyroidism (HPO), Kidney Int. 12: 459.

    Google Scholar 

  114. Transbøl, I., Schønau Jørgensen, F., Hornum, I., and Keiding, N., 1977, Hypercalcaemia discrimination index: A multivariate analysis of parathyroid function in 107 hypercalcaemic patients, Acta Endocrinol. 86: 768–783.

    PubMed  Google Scholar 

  115. Flueck, J.A., DiBella, F.P., Edis, A.J., Kehrwald, J.M., and Arnaud, C.D., 1977, Immunoheterogeneity of parathyroid hormone in venous effluent serum from hyperfunctioning parathyroid glands, J. Clin. Invest. 60: 1367–1375.

    PubMed  CAS  Google Scholar 

  116. Wang, C.-A., 1977, Parathyroid re-exploration: A clinical and pathological study of 112 cases, Ann. Surg. 186: 140–145.

    PubMed  CAS  Google Scholar 

  117. Purnell, D.C., Scholz, D.A., and Beahrs, O.H., 1977, Hyperparathyroidism due to single gland enlargement, Arch. Surg. 112: 369–372.

    PubMed  CAS  Google Scholar 

  118. Brennan, M.F., Brown, E.M., Sears, H.F., and Aurbach, G.D., 1978, Human parathyroid cryopreservation: In vitro testing of function by parathyroid hormone release, Ann. Surg. 187: 87–90.

    CAS  Google Scholar 

  119. Slatopolsky, E., Rutherford, W.E., Hruska, K., Martin, K., and Klahr, S., 1978, How important is phosphate in the pathogenesis of renal osteodystrophy?, Arch. Intern. Med. 138: 848–852.

    PubMed  CAS  Google Scholar 

  120. Massry, S.G., and Ritz, E., 1978, The pathogenesis of secondary hyperparathyroidism of renal failure: Is there a controversy?, Arch. Intern. Med. 138: 853–856.

    PubMed  Google Scholar 

  121. Jensen, P.S., and Kliger, A.S., 1977, Early radiographic manifestations of secondary hyperparathyroidism associated with chronic renal disease, Radiology 125: 645–652.

    PubMed  CAS  Google Scholar 

  122. Debnam, J.W., Bates, M.L., Kopelman, R.C., and Teitelbaum, S.L., 1977, Radiological/pathological correlations in uremic bone disease, Radiology 125: 653–658.

    PubMed  CAS  Google Scholar 

  123. Fletcher, P.D., Scopp, I.W., and Hersh, R.A., 1977, Oral manifestations of secondary hyperparathyroidism related to long-term hemodialysis therapy, Oral Surg. Oral Med. Oral Pathol. 43: 218–226.

    PubMed  CAS  Google Scholar 

  124. Chatterjee, S.N., Friedler, R.M., Bergen, T.V., Oldham, S.B., Singer, F.R., and Massry, S.G., 1976, Persistent hypercalcemia after successful renal transplantation, Nephron 17: 1–7.

    PubMed  CAS  Google Scholar 

  125. Christensen, M.S., and Nielsen, H.E., 1977, The clinical significance of hyperparathyroidism after renal transplantation, Scand. J. Urol. Nephrol. 42(Suppl.): 130–133.

    Google Scholar 

  126. Pieper, R., Alveryd, A., Lundgren, G., Collste, H., Magnusson, G., Svahn, T., and Groth, C.G., 1977, Secondary hyperparathyroidism and its sequelae in renal transplant recipients, Scand. J. Urol. Nephrol. 42(Suppl.): 144–148.

    Google Scholar 

  127. Geis, W.P., Popovtzer, M.M., Corman, J.L., Halgrimson, C.G., Groth, C.G., and Starzl, T.E., 1973, The diagnosis and treatment of hyperparathyroidism after renal homotransplantation, Surg. Gynecol. Obstet. 137: 997–1010.

    PubMed  CAS  Google Scholar 

  128. Lundgren, G., Asaba, M., Magnusson, G., Pieper, R., and Alveryd, A., 1977, The role of parathyroidectomy in the treatment of secondary hyperparathyroidism before and after renal transplantation, Scand. J. Urol. Nephrol. 42(Suppl.): 149–152.

    Google Scholar 

  129. Rose, G.A., and Vas, C.J., 1966, Neurological complications and electroen-cephalographic changes in hypoparathyroidism, Acta Neurol. Scand. 42: 537–550.

    PubMed  CAS  Google Scholar 

  130. Fonesca, O.A., and Calverley, J.R., 1967, Neurological manifestations of hypoparathyroidism, Arch. Intern. Med. 120: 202–206.

    Google Scholar 

  131. Luttwig, G., 1903, Ein Fall von Chronischer Tetanie (dissertation), Munich.

    Google Scholar 

  132. Palmer, R.F., Searles, H.H., and Boldrey, E.B., 1959, Papilledema and hypoparathyroidism simulating brain tumor, J. Neurosurg. 16: 378–384.

    PubMed  CAS  Google Scholar 

  133. Grant, D.K., 1953, Papilloedema and fits in hypoparathyroidism, Q.J. Med. 22: 243–259.

    PubMed  CAS  Google Scholar 

  134. Sambrook, M.A., and Hill, L.F., 1977, Cerebrospinal fluid absorption in primary hypoparathyroidism, J. Neurol. Neurosurg. Psychiatry 40: 1015–1017.

    PubMed  CAS  Google Scholar 

  135. Drezner, M.K., Neelon, F.A., Haussler, M., McPherson, H.T., and Lebovitz, A.E., 1976, 1,25-Dihydroxycholecalciferol deficiency: The probable cause of hypocalcemia and metabolic bone disease in pseudohypoparathyroidism, J. Clin. Endocrinol. Metab. 42: 621–628.

    PubMed  CAS  Google Scholar 

  136. Metz, S.A., Baylink, D.J., Hughes, M.R., Haussler, M.R., and Robertson, R.P., 1977, Selective deficiency of 1,25-dihydroxycholecalciferol: A cause of isolated skeletal resistance to parathyroid hormone, N. Engl. J. Med. 297: 1084–1090.

    PubMed  CAS  Google Scholar 

  137. Williams, A.J., Wilkinson, J.L., and Taylor, W.H., 1977, Pseudohypoparathyroidism: Variable manifestations within a family, Arch. Dis. Child. 52: 798–800.

    PubMed  CAS  Google Scholar 

  138. Connors, M.H., Irias, J.J., and Golabi, M., 1977, Hypo-hyperparathyroidism: Evidence for a defective parathyroid hormone, Pediatrics 60: 343–348.

    PubMed  CAS  Google Scholar 

  139. Wiegmann, T., and Kaye, M., 1977, Hypomagnesemic hypocalcemia, Arch. Intern. Med. 137: 953–955.

    PubMed  CAS  Google Scholar 

  140. Gabow, P.A., Hanson, T.J., Popovtzer, M.M., and Schrier, R.W., 1977, Furosemide-induced reduction in ionized calcium in hypoparathyroid patients, Ann. Intern. Med. 86: 579–581.

    PubMed  CAS  Google Scholar 

  141. Drezner, M.K., Neelon, F.A., Jowsey, J., and Lebovitz, H.E., 1977, Hypoparathyroidism: A possible cause of osteomalacia, J. Clin. Endocrinol. Metab. 45: 114–122.

    PubMed  CAS  Google Scholar 

  142. Chesney, R.W., Horowitz, S.D., Kream, B.E., Eisman, J.A., Hong, R., and DeLuca, H.F., 1977, Failure of conventional doses of 1α,25-dihydroxycholecalciferol to correct hypocalcemia in a girl with idiopathic hypoparathyroidism, N. Engl. J. Med. 297: 1272–1275.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Beth Israel Hospital, Boston, Massachusetts, 02115, USA

    Karen Kleeman

  2. Division of Nephrology, Department of Medicine, University of California at Los Angeles School of Medicine and Center for the Health Sciences, Los Angeles, California, 90024, USA

    Charles R. Kleeman

Authors
  1. Karen Kleeman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Charles R. Kleeman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Thorndike Laboratory of Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts, USA

    Sidney H. Ingbar M.D. (William B. Cartle Professor of Medicine, Director) (William B. Cartle Professor of Medicine, Director)

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer Science+Business Media New York

About this chapter

Cite this chapter

Kleeman, K., Kleeman, C.R. (1979). Parathyroid Hormone. In: Ingbar, S.H. (eds) Contemporary Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4857-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-4857-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4859-8

  • Online ISBN: 978-1-4757-4857-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation