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Renin-Angiotensin-Aldosterone

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Contemporary Endocrinology

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Abstract

In recumbent man, the periodicity of adrenocorticotropin (ACTH) and plasma renin activity (PRA) is well established—a daytime downward drift with an early-morning surge. In upright man, however, the patterns differ. Although the circadian rhythm of ACTH and its effect on corticosteroids persists regardless of position, assumption of upright posture in daytime causes an increase in PRA, resulting in a biphasic pattern. The rhythms of ACTH-dependent steroids, cortisol, corticosterone, and deoxycorticosterone remain unchanged regardless of posture. In addition, aldosterone has an ACTH-dependent pattern when PRA is fixed or virtually inoperative during recumbency. However, with assumption of upright posture after overnight recumbency, the increase in PRA produces a peak in plasma aldosterone concentration and this results in a biphasic plasma aldosterone response to upright posture. During recumbency, the early-morning surges of ACTH and PRA seem to be closely related. However, with assumption of upright posture, there is clear separation between the increase in PRA and the diminishing ACTH effect that usually occurs between 8:00 A.M. and 12:00 noon, when most postural studies are undertaken.1

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Authors and Affiliations

  1. Department of Medicine, University of California School of Medicine, San Francisco, California, 94110, USA

    Edward G. Biglieri

  2. Endocrine Division of Medical Service, San Francisco General Hospital Medical Center, San Francisco, California, 94110, USA

    Edward G. Biglieri

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  1. Edward G. Biglieri
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Editors and Affiliations

  1. Thorndike Laboratory of Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts, USA

    Sidney H. Ingbar M.D. (William B. Cartle Professor of Medicine, Director) (William B. Cartle Professor of Medicine, Director)

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© 1979 Springer Science+Business Media New York

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Biglieri, E.G. (1979). Renin-Angiotensin-Aldosterone. In: Ingbar, S.H. (eds) Contemporary Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4857-4_7

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  • DOI: https://doi.org/10.1007/978-1-4757-4857-4_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4859-8

  • Online ISBN: 978-1-4757-4857-4

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