• Dorothy T. Krieger


It was previously noted in The Year in Endocrinology 1975–1976 that deafferentation is associated with a decreased concentration of thyrotropin-releasing hormone (TRH) in the median eminence and anterior hypothalamus. The effect of such a procedure on hypothalamic gonadotropin-releasing hormone (GnRH) concentrations is controversial. Results of studies in which the effect both of brain lesions and of hypothalamic deafferentation on hypothalamic somatostatin concentrations were investigated suggest that most hypothalamic somatostatin originates from neurons in the anterior periventricular region, and that somatostatin in the amygdala and cortex does not arise from hypothalamic neurons.1


Growth Hormone Vasoactive Intestinal Polypeptide Corticotropin Release Factor Median Eminence Arcuate Nucleus 
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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • Dorothy T. Krieger
    • 1
  1. 1.Division of Endocrinology, Mount Sinai Medical Center and School of MedicineCity University of New YorkNew YorkUSA

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