Oxygen Diffusion Coefficients for Blood Flowing down a Wetted-Wall Column

  • Daniel Hershey
  • Carl J. Miller
  • Ronald C. Menke
  • John F. Hesselberth


Using a wetted-wall column one meter in length to produce a falling film, whole blood was oxygenated with a countercurrently flowing stream of pure oxygen. From the derived trans­port equation describing this operation, overall diffusion coefficients were calculated for oxygen in whole blood. For a l-inch diameter column, the arithmetic average value for the diffusion coefficient was 2.07 × 10−5 cm2/sec in the 87 to 96 per cent saturation range. For the 1/2-inch column, the average diffusion coefficient was 2.13 × 10−5 cm2/sec in the 72 to 96 per cent range. An arithmetic average of all the data for both columns in the 72 to 96 per cent range was 2.10 × 10−5 cm2/sec at 30°C with a standard deviation of 0.42 × 10−5 cm2/sec.

Limitations of the model used are discussed and a brief review of other work in this area is presented.


Diffusion Coefficient Blood Flow Rate Cent Range Inlet Concentration Hemoglobin Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Benis, A.M., Sc.D. Thesis, Massachusetts Institute of Technology, 1964.Google Scholar
  2. 2.
    Collins, R.E., “Transport of Gases Through Hemoglobin Solutions”, Science 133., 1593 (1961).Google Scholar
  3. 3.
    Enns, T., “Molecular Collision-Exchange Transport of Oxygen by Hemoglobin”, Proc. Nat. Acad. Sci., USA, 51, 247 (1964).CrossRefGoogle Scholar
  4. 4.
    Danckwerts, P.V., Transactions of Faraday Society, 47, 1014–1023 (1951).CrossRefGoogle Scholar
  5. 5.
    Fatt, I. and R.C. LaForce, “Theory of Oxygen Transport Through Hemoglobin Solutions”, Science, 133, 1919 (1961).CrossRefGoogle Scholar
  6. 6.
    Hartridge, H. and F.J.W. Roughton, “The Rate of Distribution of Dissolved Gases between the Red Blood Corpuscle and Its Fluid Environment”, J. Physiol. 62, 232 (1927).Google Scholar
  7. 7.
    Hemmingsen, E. and Scholander, P.F., Science 132, 1374 (1960).CrossRefGoogle Scholar
  8. 8.
    Hesselberth, J.F., Research in Progress, University of Cincinnati, Cincinnati, Ohio, 1966.Google Scholar
  9. 9.
    Kreuzer, F. and W.Z. Yahr, Influence of Red Cell Membrane on Diffusion of Oxygen, J. Appl. Physiol., 15, 1117 (1960).Google Scholar
  10. 10.
    Marx, T.I., W.E. Snyder, A.D. St. John, and C.E. Moeller, “Diffusion of Oxygen into a Film of Whole Blood”, J. Appl. Physiol. 15, 1123, (1960).Google Scholar
  11. 11.
    Menke, R.C., Research in Progress, University of Cincinnati, Cincinnati, Ohio, 1966Google Scholar
  12. 12.
    Miller, C.J., “Mass Transfer of Oxygen into Blood Using a Wetted-Wall Column”, University of Cincinnati, M.S. Thesis, 1965.Google Scholar
  13. 13.
    Rosenthal, T.B., “The Effect of Temperature on the pH of Blood and Plasma in Vitro”, J. Biol. Chem., 73, 25 (1948).Google Scholar
  14. 14.
    Roughton, F.J.W. and J.C. Rupp, “Problems Concerning the Kinetics of the Reactions of Oxygen Carbon Monoxide and Carbon Dioxide in the Intact Red Cell”, Ann. N.Y. Acad. Sci. 75, 156 (1963).CrossRefGoogle Scholar
  15. 15.
    Roughton, F.J.W., Progress in Biophysics and Biophysical Chemistry, 9., 55 (1959)Google Scholar
  16. 16.
    Scholander, P.F., Science 131, 585 (1960).CrossRefGoogle Scholar
  17. 17.
    Severinghaus, J.W., “Oxyhemoglobin Dissociation Curve,” J. Appl. Physiol., 12, 485 (1964).Google Scholar
  18. 18.
    Thews, G., Pfluger Arch. Ges. Physiol., 268, 308 (1959).CrossRefGoogle Scholar
  19. 19.
    Thews, G. and Niesel, W., Pfluger Arch. Ges. Physiol., 263, 318 (1959).CrossRefGoogle Scholar
  20. 20.
    Wang, J.H., “Transport of Oxygen Through Hemoglobin Solutions”, Science, 133, 1770 (1961).CrossRefGoogle Scholar
  21. 21.
    Yoshida, F. and Oshima, N., J. Appl. Physiol. 21 (3), 915 (1966).Google Scholar

Copyright information

© Springer Science+Business Media New York 1967

Authors and Affiliations

  • Daniel Hershey
    • 1
  • Carl J. Miller
    • 1
  • Ronald C. Menke
    • 1
  • John F. Hesselberth
    • 1
  1. 1.Department of Chemical EngineeringUniversity of CincinnatiCincinnatiUSA

Personalised recommendations