Abstract
Experimental and theoretical evaluations of fixed beds of granular dextran beads for the purification of uremic lymph are described. This work was inspired by reported success in treatment of chronic uremia by repeated collection, purification, and reinfusion of thoracic duct lymph.
The experimental program demonstrated that a rapid and essentially complete separation of low molecular weight metabolites from lymph proteins in a gel bed is possible, but that the protein-rich effluent is somewhat diluted by the occurrence of viscous flow instabilities in the trailing protein boundary.
A complete theoretical description of the system which gave excellent agreement with observed behavior was achieved using a longitudinal dispersion model and parameters evaluated from available dispersion and mass transfer coefficient correlations and from analysis of some of the experimental data. The model and parameters were then used to investigate the effects of such variables as column volume, column configuration, displacement velocity, etc. on the separation process, using a digital computer. Means of stabilizing the trailing protein boundary are outlined, and general considerations involved in arriving at a final practical system design are discussed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literature Cited
Blackwell, R. J., Rayne, J. R., and Terry, W. M., Trans. Am. Inst. Mining Met. Petrol. Engrs., 216, 1 (1959).
Cohn, E. J., and Edsall, J. T., Proteins, Amino Acids, and Peptides, Reinhold, New York, 1943.
Dumore, J. M., Soc. Petrol. Engrs. J., 4, 356 (1964).
Glueckauf, E., Trans. Faraday Soc., 51, 1540 (1955).
Helfferich, F., Ion Exchange, McGraw-Hill, New York, 1962.
Hougen, O. A., Watson, K. M., and Ragatz, R. A., CPP Charts, Wiley, New York, 1960.
Klinkenberg, A., and Sjenitzer, F., Chem. Eng. Science, 6, 258 (1956).
Lightfoot, E. N., Sanchez-Palma, R. J., and Edwards, D. O., “Chromatography and Allied Fixed-Bed Separations Processes”, New Chemical Engineering Separation Techniques, H. M. Schoen, Ed., Wiley, New York, 1962.
Perkins, T. K., and Johnston, O. C., Soc. Petrol. Engrs. J., 3, 70 (1963).
Reid, R. C., and Sherwood, T. K., The Properties of Gases and Liquids, McGraw-Hill, New York, 1958.
Sarles, H. E., Artz, C. P., Smith, G. H., Hargest, T. S., and Remmers, A. R., Trans. Am. Soc. Artif. Int. Organs, 11, 165 (1965).
Sarles, H. E., Smith, G. H., Fish, J. C., Artz, C. P., Hargest, T. S., and Remmers, A. R., Trans. Am. Soc. Artif. Int. Organs, 12, 33 (1966).
Slobod, R. L., and Howlett, W. E., Soc. Petrol. Engrs. J., 4, 1 (1964).
Weinstein, A. B., Trans. Am. Soc. Artif. Int. Organs, 10, 265 (1964).
Weinstein, A. B., Wen, S. F., Shelp, W. D., and Pellett, J. R., Trans. Am. Soc. Artif. Int. Organs, 12, 26 (1966).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1967 Springer Science+Business Media New York
About this paper
Cite this paper
Cooney, D.O., Lightfoot, E.N., Weinstein, A.B., Wen, S.F., Shelp, W.D. (1967). The Suitability of Fixed-Bed Sorbers as Artificial Kidneys. In: Hershey, D. (eds) Chemical Engineering in Medicine and Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4748-5_10
Download citation
DOI: https://doi.org/10.1007/978-1-4757-4748-5_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-4750-8
Online ISBN: 978-1-4757-4748-5
eBook Packages: Springer Book Archive