The Suitability of Fixed-Bed Sorbers as Artificial Kidneys
Experimental and theoretical evaluations of fixed beds of granular dextran beads for the purification of uremic lymph are described. This work was inspired by reported success in treatment of chronic uremia by repeated collection, purification, and reinfusion of thoracic duct lymph.
The experimental program demonstrated that a rapid and essentially complete separation of low molecular weight metabolites from lymph proteins in a gel bed is possible, but that the protein-rich effluent is somewhat diluted by the occurrence of viscous flow instabilities in the trailing protein boundary.
A complete theoretical description of the system which gave excellent agreement with observed behavior was achieved using a longitudinal dispersion model and parameters evaluated from available dispersion and mass transfer coefficient correlations and from analysis of some of the experimental data. The model and parameters were then used to investigate the effects of such variables as column volume, column configuration, displacement velocity, etc. on the separation process, using a digital computer. Means of stabilizing the trailing protein boundary are outlined, and general considerations involved in arriving at a final practical system design are discussed.
KeywordsMass Transfer Coefficient Mass Transfer Resistance Artificial Kidney Effluent Volume Thoracic Duct Lymph
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