Autoantibodies to the Cytoskeleton in Human Sera
Autoantibodies that recognize a wide range of membrane, cytoplasmic, and nuclear determinants have been detected in human sera. In some cases, these antibodies are diagnostic of particular diseases; for example, antinuclear antibodies (ANA) are viewed as specific serological markers of connective tissue disorders such as systemic lupus erythematosus (SLE) (Tan, 1981). They may also be responsible for disease. The multisystem disorders associated with SLE and other connective tissue diseases result from immunopathologically mediated tissue injury caused by the presence of a variety of autoantibodies (Kohler and Vaughan, 1982). The impairment of thyroid function in Graves’ disease is due to circulating antibodies against the receptor for thyroid-stimulating hormone (TSH) (Pinchera et al, 1980).
KeywordsSystemic Lupus Erythematosus Primary Biliary Cirrhosis Intermediate Filament Stress Fiber Human Seron
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