Autoantibodies to the Cytoskeleton in Human Sera

  • Janet M. Oliver
  • Jean-Luc Senecal
  • Naomi L. Rothfield

Abstract

Autoantibodies that recognize a wide range of membrane, cytoplasmic, and nuclear determinants have been detected in human sera. In some cases, these antibodies are diagnostic of particular diseases; for example, antinuclear antibodies (ANA) are viewed as specific serological markers of connective tissue disorders such as systemic lupus erythematosus (SLE) (Tan, 1981). They may also be responsible for disease. The multisystem disorders associated with SLE and other connective tissue diseases result from immunopathologically mediated tissue injury caused by the presence of a variety of autoantibodies (Kohler and Vaughan, 1982). The impairment of thyroid function in Graves’ disease is due to circulating antibodies against the receptor for thyroid-stimulating hormone (TSH) (Pinchera et al, 1980).

Keywords

Systemic Lupus Erythematosus Primary Biliary Cirrhosis Intermediate Filament Stress Fiber Human Seron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Janet M. Oliver
    • 1
  • Jean-Luc Senecal
    • 2
  • Naomi L. Rothfield
    • 3
  1. 1.Department of PathologyUniversity of New Mexico School of MedicineAlbuquerqueUSA
  2. 2.Notre Dame HospitalRheumatic Disease UnitMontrealCanada
  3. 3.Division of Rheumatic Diseases, Department of MedicineUniversity of Connecticut Health CenterFarmingtonUSA

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