Abstract
Many important problems related to the biology, diagnosis, and management of breast cancer require the accurate assessment of the presence of tumors and of their size and extent of growth. Biological markers are substances made by tumors, or substances or biological phenomena closely associated with the presence of tumors. These markers may be specific for breast cancer, or they may be quantitatively altered in tumor-bearing subjects, and thereby can aid in the identification of tumors and in the assessment of tumor burden. Although some useful markers can be measured chemically, most have been detected by immunological assays. In recent years, there has been growing interest in the clinical application of immunological assays for the evaluation of patients with cancer. This increasing interest has been due in part to recent advances in radioimmunoassays (RIAs) and other highly sensitive immunological techniques that allow measurement of picogram or nanogram quantities of antigens. In addition, immunological assays can be exquisitely specific, and in some instances can discriminate between molecules with differences in a single amino acid or sugar. Such procedures have provided the basis of discrimination of products of various types of neoplastic cells from normal cellular materials.
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References
S. Shapiro, Evidence on screening for breast cancer from a randomized trial, Cancer 39, 2772–2782 (1977).
J. C. Bailar III, Screening for early breast cancer: Pros and cons, Cancer 39, 2783–2795 (1977).
L. V. Ackerman and A. L. Katzenstein, The concept of minimal breast cancer and the pathologist’s role in the diagnosis of “early carcinoma,” Cancer 39, 2755–2763 (1977).
D. E. Anderson, Genetic study of breast cancer: Identification of a high risk group, Cancer 34, 1090–1097 (1974).
S. Shapiro, J. Goldberg, and G. Hutchison, Lead time in breast cancer detection and implication for periodicity of screening, Am. J. Epidemiol. 100, 357–366 (1974).
C. D. Haagensen, Diseases of the Breast, 2nd Ed., pp. 155–176, W. B. Saunders, Philadelphia (1971).
P. LoGerfo, J. Krupey, and H. J. Hansen, Demonstration of an antigen common to several varieties of neoplasia: Assay using zirconyl phosphate gel, N. Engl. J. Med. 285, 138–141 (1971).
G. Reynoso, T. M. Chu, D. Holyoke, E. Cohen, T. Nemoto, J. J. Wang, J. Chuang, P. Guinan, and G. P. Murphy, Carcinoembryonic antigen in patients with different cancers, J. Am. Med. Assoc. 220, 361–365 (1972).
T. M. Chu and T. Nemoto, Evaluation of carcinoembryonic antigen in human mammary carcinoma, J. Natl. Cancer Inst. 51, 1119–1122 (1973).
D. J. R. Laurence, U. Stevens, R. Bettelheim, D. Darcy, C. Leese, C. Turberville, P. Alexander, E. W. Johns, and A. M. Neville, Role of plasma carcinoembryonic antigen in diagnosis of gastrointestinal, mammary, and bronchial carcinoma, Br. Med. 3, 605–609 (1972).
A. M. Steward, D. Nixon, N. Zamcheck, and A. Aisenberg, Carcinoembryonic antigen in breast cancer patients: Serum levels and disease progress, Cancer 33,1246–1252 (1974).
D. Y. Wang, R. D. Bulbrook, J. L. Hayward, J. C. Hendrick, and P. Franchimont, Relationship between plasma carcinoembryonic antigen and prognosis in women with breast cancer, Eur. J. Cancer 11, 615–618 (1975).
I. C. Henderson, J. Lokich, R. Mayer, A. Skarin, and N. Zamcheck, Carcinoembryonic antigen (CEA) levels in metastatic breast cancer: Quantitative correlation with pattern of metastases, Proc. Am. Assoc. Cancer Res. 17, 202 (1976).
P. Franchimont, P. F. Zangerle, J. C. Hendrick, A. Reuter, and C. Colin, Simultaneous assays of cancer associated antigens in benign and malignant breast diseases, Cancer 39, 2806–2812 (1977).
R. C. Coombes, T. J. Powles, J. C. Gazet, H. T. Ford, J. P. Sloane, D. J. R. Laurence, and A. M. Neville, Biochemical markers in human breast cancer, Lancet 1, 132–134 (1977).
D. C. Tormey, T. P. Waalkes, J. J. Snyder, and R. M. Simon, Biological markers in breast carcinoma. III. Clinical correlations with carcinoembryonic antigen, Cancer 39, 2397–2404 (1977).
R. E. Myers, D. J. Sutherland, J. A. Kellen, D. G. Malkin, and A. Malkin, CEA in breast cancer, Cancer (in press) (1978).
D. E. Haagensen, Jr., S. J. Kister, J. P. Vandevoorde, J. B. Gates, E. K. Smart, H. J. Hansen, and S. A. Wells, Jr., Evaluation of carcinoembryonic antigen as a plasma monitor for human breast carcinoma, Cancer (in press) (1978).
M. Bordes, R. Michiels, and F. Martin, Detection by immunofluorescence of carcinoembryonic antigen in colonic carcinoma, other malignant or benign tumours, and noncancerous tissues, Digestion 9, 106–115 (1973).
E. Heyderman and A. M. Neville, A shorter immunoperoxidase technique for the demonstration of carcinoembryonic antigen and other cell products, J. Clin. Pathol. 30, 138–140 (1977).
G. Pusztaszeri and J.-P. Mach, Carcinoembryonic antigen (CEA) in non-digestive cancerous and normal tissues, Immunochemistry 10, 197–204 (1973).
P. Sizaret and F. Martin, Carcinoembryonic antigen in extracts of pulmonary cancers, J. Natl. Cancer Inst. 50, 807–810 (1973).
H. Denk, G. Tappeiner, R. Eckerstorfer, and J. H. Holzner, Carcinoembryonic antigen (CEA) in gastrointestinal and extragastrointestinal tumors and its relationship to tumor-cell differentiation, Int. J. Cancer 10, 262–272 (1972).
D. M. Goldenberg, F. J. Primus, and F. Deland, Tumor detection and localization with purified antibodies to carcinoembryonic antigen, in: Immunodiagnosis of Cancer (R. B. Herberman and K. R. Mclntire, eds.), Marcel Dekker, New York (1978).
G. D. Braunstein, J. L. Vaitukaitis, P. P. Carbone, and G. T. Ross, Ectopic production of human chorionic gonadotrophin by neoplasms, Ann. Intern. Med. 78, 39–48 (1973).
N. A. Sheth, J. N. Suraiya, K. J. Ranadive, and A. R. Sheth, Ectopic production of human chorionic gonadotrophin by human breast tumors, Br. J. Cancer 30, 566–570 (1974).
D. C. Tormey, T. P. Waalkes, D. Ahmann, C. W. Gehrke, R. W. Zumwatt, J. Snyder, and H. Hansen, Biological markers in breast carcinoma. I. Incidence of abnormalities of CEA, HCG, three polyamines, and three minor nucleosides, Cancer 35, 1095–1100 (1975).
D. C. Tormey, T. P. Waalkes, and R. M. Simon, Biological markers in breast carcinoma. II. Clinical correlations with human chorionic gonadotrophin, Cancer 39, 2391–2396 (1977).
C. H. W. Home, I. N. Reid, and G. D. Milne, Prognostic significance of inappropriate production of pregnancy proteins by breast cancers, Lancet 2, 279–282 (1976).
N. A. Sheth, J. N. Suraiya, A. R. Sheth, K. J. Ranadive, and D. J. Jussawalla, Ectopic production of human placental lactogen by human breast tumors, Cancer 39, 1693–1699 (1977).
W. H. Stimson, J. M. Anderson, and D. M. Farquharson, Pregnancy-associated α 2-glycoprotein, Lancet 1, 542–543 (1977).
M. G. Damber, B. Von Schoultz, and T. Stigbrand, Pregnancy-associated α-2-glycoprotein and cancer, Lancet 1, 1182–1184 (1976).
W. H. Fishman and L. L. Stolbach, Placental alkaline phosphatase, in: Immunodiag-nosis of Cancer (R. B. Herberman and K. R. Mclntire, eds.), Marcel Dekker, New York (in press).
E. M. Edynak, L. J. Old, M. Vrana, and M. P. Lardis, A fetal antigen associated with human neoplasia, N. Engl. J. Med. 286, 1178–1183 (1972).
E. M. Edynak, M. P. Lardis, and M. Vrana, Antigenic changes in human breast neoplasia, Cancer 28, 1457–1461 (1971).
J. C. Hendrick and P. Franchimont, Radioimmunoassay of casein in the serum of normal subjects and patients with various malignancies, Eur. J. Cancer 10, 725–730 (1974).
M. E. Monaco, D. A. Bronzert, D. C. Tormey, P. Waalkes, and M. E. Lippman, Casein production by human breast cancer, Cancer Res. 37, 749–754 (1977).
J. Hurlimann, M. Lichea, and L. Ozzello, In vitro synthesis of immunoglobulins and other proteins by dysplastic and neoplastic human mammary tissues, Cancer Res. 36, 1284–1292 (1976).
P. Franchimont, J. C. Hendrick, A. Thirion, and P. F. Zangerie, Kappa-casein: An index of normal mammary function and a tumor associated antigen, in: Immunodiag-nosis of Cancer (R. B. Herberman and K. R. Mclntire, eds.), Marcel Dekker, New York (in press).
D. E. Haagensen, Jr., G. Mazoujian, W. D. Holder, Jr., S. J. Kister, and S. A. Wells, Jr., Evaluation of a breast cyst fluid protein detectable in the plasma of breast carcinoma patients, Ann. Surg. 185, 279–285 (1977).
D. E. Haagensen, S. J. Kister, J. Panick, J. Giannola, H. J. Hansen, and S. A. Wells, Jr., Comparative evaluation of carcinoembryonic antigen and gross cystic disease fluid protein as plasma markers for human breast carcinoma, Cancer (in press) (1978).
D. L. Kleinberg, Human a-lactalbumin: Measurement in serum and in breast cancer organ cultures by radioimmunoassay, Science, 190, 276–278 (1975).
P. H. Rurnke, D. Bisser, H. G. Kwa, and A. A. M. Hart, Radioimmunoassay of lactoferrins in blood plasma of breast cancer patients, lactating and normal women: Prevention of false high levels caused by leakage from neutrophile leucocytes in vitro, Folia Med. Need. 14, 156–160 (1971).
J. F. Chiu, L. S. Hnilica, F. Chytil, J. T. Orrahood, and L. W. Rogers, Tissue specific antibodies against human lung and breast carcinoma dehistonized chromatins, J. Natl Cancer Inst. 59, 151–154 (1977).
R. C. Coombes, G. C. Easty, S. I. Detre, C. J. Hillyard, U. Stevens, S. I. Girgis, L. S. Galante, L. Heywood, I. Maclntyre, and A. M. Neville, Secretion of immunoreactive calcitonin by human breast carcinomas, Br. Med. j. 4, 197–199 (1975).
A. M. Neville, R. C. Coombes, C. J. Hillyard, and I. Maclntire, Calcitonin as a tumour marker, in: Cancer Related Antigens (P. Franchimont, ed.), pp. 151–162, North-Holland Publishing Co., Amsterdam (1976).
C. J. Hillyard, R. C. Coombes, P. B. Greenberg, L. S. Galante, and I. Maclntyre, Calcitonin in breast and lung cancer, Clin. Endocrinol. 5, 1–8 (1976).
N. A. Sheth, K. J. Ranadive, J. N. Suraiya, and A. R. Sheth, Circulating levels of prolactin in human breast cancer, Br. J. Cancer 32, 160–167 (1975).
E. J. Hawrylewicz, W. H. Blair, and L. W. Giltner, Diagnostic value of serum LDH isoenzyme patterns in women with breast lesions, in: Proceedings of the Third International Symposium on the Detection and Prevention of Cancer, Marcel Dekker, New York (in press).
W. H. Blair, E. J. Hawrylewicz, and L. W. Giltner, Serum LDH isoenzymes as an indicator for the presence and recurrence of breast carcinoma, in: Proceedings of the Third International Symposium on the Detection and Prevention of Cancer, Marcel Dekker, New York (in press).
H. B. Bosmann and T. C. Hall, Enzyme activity in invasive tumors of human breast and colon, Proc. Natl. Acad. Sci. U.S.A. 71, 1833–1837 (1974).
M. Henderson and D. Kessel, Alterations in plasma sialyltransferase levels in patients with neoplastic disease, Cancer 39, 1129–1134 (1977).
D. M. Marcus and N. Zinberg, Isolation of ferritin from human mammary and pancreatic carcinomas by means of antibody immunoadsorbents, Arch. Biochem. Biophys. 162, 493–501 (1974).
D. M. Marcus and N. Zinberg, Measurement of serum ferritin by radioimmunoassay: Results in normal individuals and patients with breast cancer, J. Natl. Cancer Inst. 55, 791–795 (1975).
I. Davidsohn, The loss of blood group antigens A, B and H from cancer cells, in: Immunodiagnosis of Cancer (R. B. Herberman and K. R. Mclntire, eds.), Marcel Dekker, New York (in press).
R. K. Gupta and D. Schuster, Isoantigens A, B and H in benign and malignant lesions of breast, Am. J. Pathol. 72, 253–260 (1973).
G. F. Springer, P. R. Desai, and I. Banatwala, Blood group MN antigens and precursors in normal and malignant human breast glandular tissue, J. Natl. Cancer Inst. 54, 335–339 (1975).
G. F. Springer, P. R. Desai, and E. F. Scanlon, Blood group MN precursors as human breast carcinoma-associated antigens and “naturally” occurring human cytotoxins against them, Cancer 37, 169–176 (1976).
B. Björklund, Review of the immunochemical and clinical significance of TPA, in: Protides of the Biological Fluids (H. Peeters, ed.), pp. 505–512, Pergamon Press, Oxford (1976).
B. Björklund, V. Björklund, R. Lundström, and G. Eklund, Tissue polypeptide antigen (TPA) in human cancer defense responses, in: The Reticuloendothelial System in Health and Disease: Immunologic and Pathologic Aspects (H. Friedman, M. R. Escobar, and S. M. Reichard, eds.), pp. 357–370, Plenum Press, New York (1976).
D. Holyoke and T. M. Chu, Tissue polypeptide antigen (TPA), in: Immunodiagnosis of Cancer (R. B. Herberman and K. R. Mclntire, eds.), Marcel Dekker, New York (in press).
C. V. Menandez-Botet and M. K. Schwartz, A pulmonary evaluation of tissue polypeptide antigen (TPA) in serum and/or urine of patients with cancer or benign diseases, Proceedings of the Folksam Symposium, Bonniers, Stockholm (1975).
W. Mattsson and S. Börjstrom, TPA as a guide in antineoplastic and hormonal treatment of advanced mammary carcinoma, Proceedings of the Folksam Symposium, Bonniers, Stockholm (1975).
C. E. Guzzo, W. N. Pachas, R. S. Pinals, and M. J. Krant, Urinary hydroxyproline excretion in patients with cancer, Cancer 24, 382–387 (1969).
T. J. Powles, C. L. Leese, and P. K. Bondy, Hydroxyproline excretion in patients with breast cancer and response to treatment, Br. Med. J. 2, 164–166 (1975).
V. Riley, Breast cancer patients: Substance in blood causing acceleration of erythrocyte sedimentation rate, Science 191, 86–88 (1976).
J. G. Roberts, J. W. Keyser, and M. Baum, Serum α-1-acid glycoprotein as an index of dissemination in breast cancer, Br. J. Surg. 62, 816–819 (1975).
M. Mueller and H. Grossman, An antigen in human breast cancer sera related to the murine mammary tumor virus, Nature (London) 237, 116–117 (1972).
I. N. Kryukova, K. V. Ilyin, N. N. Mazurenko, L. N. Vasilevskaya, and V. M. Zhdanov, Immunologic study of antigens and molecular hybridization of nucleic acids from milk of breast cancer patients, Neoplasma 22, 235–241 (1975).
J. Yeh, M. Ahmed, S. A. Mayyasi, and A. A. Alessi, Detection of an antigen related to Mason-Pfizer virus in malignant human breast tumors, Science 190, 583–584 (1975).
M. M. Black, T. H. C. Barclay, and B. F. Hankey, Prognosis in breast cancer utilizing histologic characteristics of the primary tumor, Cancer 36, 2048–2055 (1975).
R. L. Hunter, D.J. Ferguson, and L. W. Coppleson, Survival with mammary cancer related to the interaction of germinal center hyperplasia and sinus histiocytosis in axillary and internal mammary lymph nodes, Cancer 36, 528–539 (1975).
G. H. Friedell, E. A. Soto, S. Kumaoka, O. Abe, J. L. Hayward, and R. D. Bulbrook, Sinus histiocytosis in British and Japanese patients with breast cancer, Lancet 2, 1228–1229 (1974).
V. Tsakraklides, P. Olson, J. H. Kersey, and R. A. Good, Prognostic significance of regional lymph node histology in cancer of the breast, Cancer 34, 1259–1267 (1974).
S. D. Deodhar, G. Crile, Jr., and C. B. Esselstyn, Jr., Study of the tumor cell-lymphocyte interaction in patients with breast cancer, Cancer 29, 1321–1325 (1972).
L. Flores, M. Arlen, A. Elguezabal, S. F. Livingston, and B. S. Levowitz, Host tumor relationships in medullary carcinoma of the breast, Surg. Gynecol. Obstet. 139, 683–688 (1974).
E. Tsakraklides, V. Tsakraklides, H. Ashikari, P. P. Rosen, F. P. Siegal, G. F. Rob-bins, and R. A. Good, In vitro studies of axillary lymph node cells in patients with breast cancer, J. Natl. Cancer Inst. 54, 549–556 (1975).
E. R. Fisher, E. Saffer, and B. Fisher, Studies concerning the regional lymph node in cancer. VI. Correlation of lymphocyte transformation of regional node cells and some histopathologic discriminants, Cancer 32, 104–111 (1973).
J. F. Djeu, J. L. McCoy, G. B. Cannon, W. J. Reeves, W. H. West, and R. B. Herberman, Lymphocytes forming rosettes with sheep erythrocytes in metastatic pleural effusions, J. Natl. Cancer Inst. 56, 1051–1052 (1976).
S. A. Richters and C. L. Kaspersky, Surface immunoglobulin positive lymphocytes in human breast cancer tissue and homolateral axillary lymph nodes, Cancer 35, 129–133 (1975).
K. Irie, R. F. Irie, and D. L. Morton, Detection of antibody and complement complexée! in vivo on membranes of human cancer cells by mixed hemoadsorption techniques, Cancer Res. 35, 1244–1248 (1975).
A. V. Richman, Immunofluorescence studies of benign and malignant human mammary tissue, J. Natl. Cancer Inst. 57, 263–267 (1976).
M. M. Roberts, E. M. Bass, and W. J. Wallace, Antibody production in breast cancer, Br. J. Surg. 59, 904 (1972).
R. H. Waldman, J. P. Mach, M. M. Stella, and D.S. Rowe, Secretory IgA in human serum, J. Immunol. 105, 43–47 (1970).
J. P. Harris, M. H. Caleb, and M. A. South, Secretory component in human mammary carcinoma, Cancer Res. 35, 1861–1864 (1975).
E. D. Savlov, J. L. Witliff, and R. Hilf, Further studies of biochemical predictive tests in breast cancer, Cancer 39, 539–541 (1977).
R. B. Herberman, Cell-mediated immunity to tumor cells, in: Advances in Cancer Research (G. Klein and S. Weinhouse, eds.), Vol. 19, pp. 207–263, Academic Press, New York (1974).
K. K. Meyer, G. L. Mackler, and W. C. Beck, Increased IgA in women free of recurrence after mastectomy and radiation, Arch. Surg. 107, 159–161 (1973).
A. E. Papatestas, G. J. Lesnick, G. Genkins, and A. H. Aufses, The prognostic significance of peripheral lymphocyte counts in patients with breast carcinoma, Cancer 37, 164–168 (1976).
U. Glas, J. Wasserman, H. Blomgren, and A. De Schryver, Lymphopenia and metastatic breast cancer patients with and without radiation therapy, Int. J. Radiât. Oncol. Biol. Phys. 1, 189–195 (1976).
J. A. McCredie, W. R. Inch, and R. M. Sutherland, Peripheral blood lymphocytes and breast cancer: Effects of operation and radiotherapy, Arch. Surg. 107, 162–165 (1973).
J. Stjernswärd, M. Jondal, F. Vanky, H. Wigzell, and R. Sealy, Lymphopenia and change in distribution of human B and T lymphocytes in peripheral blood induced by irradiation for mammary carcinoma, Lancet 1, 1352–1356 (1972).
W. H. West, C. W. Sienknecht, A. S. Townes, and R. B. Herberman, Performance of a rosette assay between lymphocytes and sheep erythrocytes at 29°C to study patients with cancer and other diseases, Clin. Immunol, lmmunopathol. 5, 60–66 (1976).
J. Djeu, S. Payne, C. Alford, W. Heim, T. Pomeroy, M. Cohen, R. Oldham, and R. B. Herberman, Detection of decreased proportion of lymphocytes forming rosettes with sheep erythrocytes at 29°C in the blood of cancer patients: Analysis of factors affecting the assay, Clin. Immunol, lmmunopathol. 8, 405–419 (1977).
J. L. Weese, R. K. Oldham, D. C. Tormey, A. L. Barlock, A. Morales, M. H. Cohen, T. C. Alford, P. E. Shorb, N. T. Tsangaris, W. H. West, C. B. Cannon, J. H. Dean, J. Djeu, J. L. McCoy, and R. B. Herberman, Immunologic monitoring in carcinoma of the breast, Surg. Gynecol. Obstet. 145, 209–218 (1977).
R. H. Whitehead, J. Thatcher, C. Teasdale, G. P. Roberts, and L. E. Hughes, T and B lymphocytes in breast cancer: Stage relationship and abrogation of T-lymphocyte depression by enzyme treatment in vitro, Lancet 1, 330–333 (1976).
R. H. Whitehead, G. P. Roberts, J. Thatcher, C. Teasdale, and L. E. Hughes, Masking of receptors for sheep erythrocytes on human T-lymphocytes by sera from breast cancer patients, J. Natl. Cancer Inst. 58, 1573–1576 (1977).
B. Petrini, J. Wasserman, H. Blomgren, and E. Baral, Blood lymphocyte subpopulations in breast cancer patients following radiotherapy, Clin. Exp. Immunol. 29, 36–42 (1977).
J. A. McCredie, W. R. Inch, and R. M. Sutherland, Effect of postoperative radiotherapy on peripheral blood lymphocytes in patients with carcinoma of the breast, Cancer 29, 349–356 (1972).
H. Blomgren, R. Berg, J. Wasserman, and U. Glas, Effect of radiotherapy on blood lymphocyte population in mammary carcinoma, Int. J. Radiat. Oncol. Biol. Phys. 1, 177–188 (1976).
M. M. Roberts and W. Jones-Williams, The delayed hypersensitivity reaction in breast cancer, Br. J. Surg. 61, 549–552 (1974).
T. J. Cunningham, D. Daut, P. E. Wolfgang, M. Mellyn, S. Maciolek, R. W. Sponzo, and J. Horton, A correlation of DNCB-induced delayed cutaneous hypersensitivity reactions and the course of disease in patients with recurrent breast cancer, Cancer 37, 1696–1700 (1976).
M. G. Whittaker and C. G. Clark, Depressed lymphocyte function in carcinoma of the breast, Br. J. Surg. 58, 717–720 (1971).
J. H. Dean, R. Connor, R. B. Herberman, J. L. McCoy, J. Silva, and R. K. Oldham, The relative proliferation index as a more sensitive parameter for evaluating lym-phoproliferative responses of cancer patients to mitogens and alloantigens, Int. J. Cancer 20, 359–370 (1977).
N. Matthews and R. H. Whitehead, Inhibition of K cell function by human breast cancer sera, Br. J. Cancer 34, 635–640 (1976).
R. Snyderman, M. C. Pike, L. Meadows, G. Hemstreet, and S. Wells, Depression of monocyte Chemotaxis by neoplasms, Clin. Res. 23, 297A (1975).
F. Loisillier, D. Buffe, K. B. Tan, P. Burtin, and P. Grabar, Etude immunologique des epitheliomas mammaires humains, Ann. Inst. Pasteur 109, 1–21 (1965).
G. Taylor and J. L. Odili, Tumour specific T-like antigen of human breast carcinoma, Br. J. Cancer 24, 447–453 (1970).
J. M. Gentile and J. T. Flickinger, Isolation of a tumor-specific antigen from adenocarcinoma of the breast, Surg. Gynecol. Obstet. 135, 69–73 (1972).
E. S. Priori, G. Seman, L. Dmochowski, H. Gallagher, and D. E. Anderson, Immunofluorescence studies on sera of patients with breast carcinoma, Cancer 28, 1462–1471 (1971).
E. M. Edynak, Y. Hirshaut, M. Bernhard, and G. Trempe, Fluorescent antibody studies of human breast cancer, J. Natl. Cancer Inst. 48, 1137–1143 (1972).
O. R. Boehm, B. J. Boehm, and L. J. Humphrey, The natural history of the antibody response to breast antigens, Clin. Exp. Immunol. 16, 31–40 (1974).
L. J. Humphrey, N. C. Estes, P. A. Morse, Jr., W. R. Jewell, R. A. Boudet, and M. J. K. Hudson, Serum antibody in patients with mammary disease, Cancer 34, 1516–1520 (1974).
J. L. Weese, The Makari skin test as an immunodiagnostic technique, in: Immunodiag-nosis of Cancer (R. B. Herberman and K. R. Mclntire, eds.), Marcel Dekker, New York (in press).
K. Honda, K. Hoshishima, K. Kato, T. Okazaki, Y. Higuchi, and M. Ikeda, Studies with the Makari skin test in Japan, Trans. N. Y. Acad. Sci. 35, 369–380 (1971).
D. E. H. Tee, Clinical evaluation of the Makari tumor skin test, Br. J. Cancer 28 (Suppl. I), 187–197 (1973).
J. Charney and D. H. Moore, Neutralization of murine mammary tumour virus by sera of women with breast cancer, Nature (London) 229, 627–628 (1971).
E. S. Priori, D. E. Anderson, W. C. Williams, and L. Dmochowski, Immunological studies on human breast carcinoma and mouse mammary tumor, J. Natl. Cancer Inst. 48, 1131–1135 (1972).
J. M. Bowen, L. Dmochowski, M. F. Miller, E. S. Priori, G. Seman, M. L. Dodson, and K. Maruyama, Implications of humoral antibody in mice and humans to breast tumor and mouse mammary tumor virus-associated antigens, Cancer Res. 36, 759–764 (1976).
K. W. Newgard, R. D. Cardiff, and P. B. Blair, Human antibodies binding to the mouse mammary tumor virus: A nonspecific reaction?, Cancer Res. 36, 765–768 (1976).
D. Stutman and R. B. Herberman, Immunological control of breast cancer: Discussion, Cancer Res. 36, 781–782 (1976).
M. M. Black and H. P. Leis, Jr., Cellular responses to autologous breast cancer tissue: Sequential observations, Cancer 32, 384–389 (1973).
L. E. Hughes and B. Lytton, Antigenic properties of human tumours: Delayed cutaneous hypersensitivity reactions, Br. Med. J. 1, 209–212 (1964).
T. H. M. Steward and M. Orizaga, The presence of delayed hypersensitivity reactions in patients toward cellular extracts of their malignant tumors. 3. The frequency, duration, and cross reactivity of this phenomenon in patients with breast cancer, and its correlation with survival, Cancer 28, 1472–1478 (1971).
C. Alford, A. C. Hollinshead, and R. B. Herberman, Delayed cutaneous hypersensitivity reactions to extracts of malignant and normal human breast cells, Ann. Surg. 178, 20–24 (1973).
A. C. Hollinshead, W. T. Jaffurs, L. K. Alpert, J. E. Harris, and R. B. Herberman, Isolation and identification of soluble skin reactive membrane antigens of malignant and normal breast cells, Cancer Res. 34, 2961–2968 (1974).
J. Weese, R. B. Herberman, R. B. Hollinshead, G. Cannon, M. Keels, and R. K. Oldham, Specificity of delayed cutaneous hypersensitivity reactions to extracts of human tumor cells, J. Natl. Cancer Inst. 60, 255–263 (1978).
V. Andersen, O. Bjerrum, G. Bendixen, T. Schiodt, and I. Dissing, Effect of autologous mammary tumor extracts on human leukocyte migration in vitro, Int. J. Cancer 5, 357–363 (1970).
A. Segall, O. Weiler, J. Genin, J. Lacour, and F. Lacour, In vitro study of cellular immunity against autochthonous human cancer, Int. J. Cancer 9, 417–425 (1972).
A. J. Cochran, R. M. Grant, W. G. Spilg, R. M. Mackie, C. E. Ross, D. E. Hoyle, and J. M. Russell, Sensitization of tumor-associated antigens in human breast carcinoma, Int. J. Cancer 14, 19–25 (1974).
J. L. McCoy, L. F. Jerome, J. H. Dean, G. B. Cannon, T. C. Alford, T. Doering, and R. B. Herberman, Inhibition of leukocyte migration by tumor-associated antigens in soluble extracts of human breast carcinoma, J. Natl. Cancer Inst. 53, 11–17 (1974).
A. S. Kadish, D. M. Marcus, and B. R. Bloom, Inhibition of leukocyte migration by human breast-cancer-associated antigens, Int. J. Cancer 18, 581–586 (1976).
J. L. McCoy, L. F. Jerome, C. Anderson, G. B. Cannon, T. C. Alford, R. J. Connor, R. K. Oldham, and R. B. Herberman, Leukocyte migration inhibition by soluble extracts of MCF-7 tissue culture cell line derived from breast carcinoma, J. Natl. Cancer Inst. 57, 1045–1049 (1976).
G. B. Cannon, J. L. McCoy, L. J. Jerome, R. Reddick, C. Alford, V. Tenley, and R. B. Herberman, Immunological relationship between breast carcinoma and benign breast disease as detected by the leukocyte migration inhibition assay, J. Natl. Cancer Inst. (in press) (1978).
M. M. Black, H. P. Leis, B. Shore, and R. E. Zachrau, Cellular hypersensitivity to breast cancer: Assessment by a leukocyte migration procedure, Cancer 33, 952–958 (1974).
M. M. Black, D. H. Moore, B. Shore, R. E. Zachrau, and H. P. Leis, Jr., Effect of murine milk samples and human breast tissues on human leukocyte migration indices, Cancer Res. 34, 1054–1060 (1974).
M. M. Black, R. E. Zachrau, B. Shore, D. H. Moore, and H. P. Leis, Jr., Prognostically favorable immunogens of human breast cancer tissue: Antigenic similarity to murine mammary tumor virus, Cancer 35, 121–128 (1975).
M. M. Black, R. E. Zachrau, B. Shore, and H. P. Leis, Jr., Biological considerations of tumor-specific and virus-associated antigens of human breast cancer, Cancer Res. 36, 769–774 (1976).
R. E. Zachrau, M. M. Black, A. S. Dion, B. Shore, M. Isac, A. M. Andrade, and C. J. Williams, Prognostically significant protein components of human breast cancer tissues, Cancer Res. 36, 3143–3146 (1976).
J. L. McCoy, J. H. Dean, G. B. Cannon, T. C. Alford, W. P. Parks, R. V. Gilden, S. T. Oroszlan, and R. B. Herberman, Leukocyte migration inhibition and lymphocyte blastogenesis responses in human breast carcinoma patients to mouse mammary tumor virus, virion gp52 and gp70 antigens, J. Natl. Cancer Inst, (in press) (1978).
P. Fischer, E. Golub, H. Holzner, and E. Kunze-Muhl, Comparative effects of tumor extracts on lymphocyte transformation in peripheral blood cultures of healthy persons and patients with breast cancer, Z. Krebsforsch. 72, 155–161 (1969).
H. Savel, Effect of autologous tumor extracts on cultured human peripheral blood lymphocytes, Cancer 24, 56–63 (1969).
C. C. S. Hsu and S. R. Cooperband, In vitro responses of lymphocytes from cancer-bearing patients to autochthonous tumor tissues, Proc. Soc. Exp. Biol. Med. 136, 446–448 (1971).
G. M. Mavligit, U. Ambus, J. U. Gutterman, and E. M. Hersh, Antigen solubilized from human solid tumors: Lymphocyte stimulation and cutaneous delayed hypersensitivity, Nature (London) New Biol. 243, 188–190 (1973).
J. H. Dean, J. L. McCoy, G. B. Cannon, C. M. Leonard, E. Perlin, A. Kreutner, R. K. Oldham, and R. B. Herberman, Cell-mediated immune responses of breast cancer patients to autologous tumor-associated antigens, J. Natl. Cancer Inst. 58, 549–555 (1977).
J. H. Dean, J. S. Silva, J. L. McCoy, C. M. Leonard, M. Middleton, G. B. Cannon, and R. B. Herberman, Lymphocyte blastogenesis induced by 3M KCl extracts of allogeneic breast carcinoma and lymphoid cells, J. Natl. Cancer Inst. 54, 1295–1298 (1975).
S. Cunningham-Rundles, W. F. Feller, C. Cunningham-Rundles, B. DuPont, H. Wanebo, R. O’Reilly, and R. A. Good, Lymphocyte transformation in vitro to RIII mouse milk antigen among women with breast disease, Cell Immunol. 25, 322–327 (1976).
I. Hellström, K. E. Hellström, H. O. Sjögren, and G. A. Warner, Demonstration of cell-mediated immunity to human neoplasms of various histological types, Int. J. Cancer 7, 1–16 (1971).
G. Fossati, S. Canevari, G. Delia Porta, G. P. Balzarini, and U. Veronesi, Cellular immunity to human breast carcinoma, Int. J. Cancer 10, 391–396 (1972).
G. Delia Porta, S. Canevari, and G. Fossati, Immune responses to tumour and embryo cells in patients with mammary carcinoma, Br. J. Cancer 28, (Suppl. I), 103–107 (1973).
R. K. Oldham, J. Y. Djeu, G. B. Cannon, D. Siwarski, and R. B. Herberman, Cellular microcytotoxicity in human tumor systems: Analysis of results, J. Natl. Cancer Inst. 55, 1305–1318 (1975).
G. Heppner, E. Henry, L. Stolbach, F. Cummings, E. McDonough, and P. Calabresi, Problems in the clinical use of the microcytotoxicity assay for measuring cell-mediated immunity to tumor cells, Cancer Res. 35, 1931–1937 (1975).
H. F. Jeejeebhoy, Immunological studies of women with primary breast carcinoma, Int. J. Cancer 15, 867–878 (1975).
S. Canevari, G. Fossati, and G. Delia Porta, Cellular immune reaction to human malignant melanoma and breast carcinoma cells, J. Natl. Cancer Inst. 56, 705–709 (1976).
R. B. Herberman and R. K. Oldham, Problems associated with study of cell-mediated immunity to human tumors by microcytotoxicity assays, J. Natl. Cancer Inst. 55, 749–753 (1975).
F. Avis, I. Mosonov, and G. Haughton, Antigenic cross-reactivity between benign and malignant neoplasms of the human breast, J. Natl. Cancer Inst. 52, 1041–1049 (1974).
G. B. Cannon, G. D. Bonnard, J. Djeu, W. H. West, and R. B. Herberman, Relationship of human natural lymphocyte-mediated cytotoxicity to cytotoxicity of breast cancer-derived target cells, Int. J. Cancer 19, 487–497 (1977).
I. Hellström, H. O. Sjögren, G. Warner, and K. E. Hellström, Blocking of cell-mediated tumor immunity by sera from patients with growing neoplasms, Int. J. Cancer 7, 226–237 (1971).
A. E. Powell, A. M. Sloss, R. N. Smith, J. L. Makley, and C. A. Hubay, Specific responsiveness of leukocytes to soluble extracts of human tumors, Int. J. Cancer 16, 905–913 (1975).
N. Grosser and D. M. P. Thomson, Cell-mediated antitumor immunity in breast cancer patients evaluated by antigen-induced leukocyte adherence inhibition in test tubes, Cancer Res. 35, 2571–2579 (1975).
M. Flores, J. R. Marti, N. Grosser, J. D. MacFarlane, and D. M. P. Thomson, An overview: Antitumor immunity in breast cancer measured by tube leukocyte adherence inhibition assay, Cancer 39, 494–505 (1977).
T. Fujisawa, S. R. Waldman, and R. H. Yonemoto, Leukocyte adherence inhibition by soluble tumor antigens in breast cancer patients, Cancer 39, 506–513 (1977).
E. A. Caspary and E. J. Field, Specific lymphocyte sensitization in cancer: Is there a common antigen in human malignant neoplasia?, Br. Med. 2, 613–617 (1971).
J. A. V. Pritchard, J. L. Moore, W. H. Sutherland, and C. A. F. Joslin, Evaluation and development of the macrophage electrophoretic mobility (MEM) test for malignant disease, Br. J. Cancer 27, 1–9 (1973).
K. D. Bagshawe, Workshop on macrophage electrophoretic mobility (MEM) and structuredness of cytoplasmic matrix (SCM) tests, Br. J. Cancer 35, 701–704 (1977).
J. A. V. Pritchard, W. H. Sutherland, and T. J. Deeley, Cancer detection, Lancet 1, 637 (1976).
L. Cercek, B. Cercek, and C. I. V. Franklin, Biophysical differentiation between lymphocytes from healthy donors, patients with malignant diseases and other disorders, Br. J. Cancer 29, 345–352 (1974).
L. Cercek, and B. Cercek, Apparent tumour specificity with the SCM test, Br. J. Cancer 31, 252–253 (1975).
L. Cercek and B. Cercek, Changes in the SCM response ratio (RRscm) after surgical removal of malignant tissue, Br. J. Cancer 31, 250–251 (1975).
A. Theofilopoulos, C. B. Wilson, and F. J. Dixon, The Raji cell radioimmune assay for detecting immune complexes in human sera, J. Clin. Invest. 57, 169–182 (1976).
R. D. Rossen, M. A. Reisberg, E. M. Hersh, and J. U. Gutterman, The C1q binding test for soluble immune complexes: Clinical correlations obtained in patients with cancer, J. Natl. Cancer Inst. 58, 1205–1211 (1977).
J. A. Stein, A. Adler, S. Ben Efram, and M. Maor, Immunocompetence, immunosuppression, and human breast cancer. I. An analysis of their relationship by known parameters of cell-mediated immunity in well-defined clinical stages of disease, Cancer 38, 1171–1187 (1976).
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Herberman, R.B. (1978). Biological Markers in Breast Cancer. In: McGuire, W.L. (eds) Breast Cancer:Advances in Research and Treatment, Vol. 2: Experimental Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4673-0_6
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