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Antiestrogens: Mechanism of Action and Effects in Breast Cancer

  • Kathryn B. Horwitz
  • William L. McGuire

Abstract

Several of the nonsteroidal antiestrogens are in experimental use for the treatment of breast cancer. The treatment goal is to obtain, with minimal toxicity, specific control over cell growth by chemical means, thereby avoiding, on the one hand, pharmacologic doses of hormones and, on the other, major surgical ablative procedures.(1) One rationale for use of estrogen antagonists is an outgrowth of our current awareness of the role of estrogen receptors (ERs) and estrogen in breast cancer. Recent reports show that hormone dependence can be predicted by use of ER measurements. If estrogen antagonists block the action of estrogen at its receptor, it would be possible to obtain, by noninvasive means, the same therapeutic end as ablative hormonal procedures. Despite considerable research to that end, however, our knowledge of the mechanism of antiestrogen action remains unclear. The purpose of this review is to summarize this research. We will review first some of the biological activities of antiestrogens in normal tissues, and the mechanisms that have been proposed for their effects, then the role of antiestrogens in experimental animal breast cancer, and the data currently available on use of antiestrogens in humans and human breast cancer.

Keywords

Breast Cancer Estrogen Receptor Nuclear Receptor Mammary Tumor Estrogen Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Kathryn B. Horwitz
    • 1
  • William L. McGuire
    • 1
  1. 1.Department of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioUSA

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