In the classic sense of carcinogenesis, such as that produced by ionizing radiation or “carcinogenic” hydrocarbons, hormones are probably not carcinogenic. They are either procarcinogens or cocarcinogens. In this sense, they produce more substrate either for initiation or for promotion by other substances, but of themselves they are probably not carcinogens. In the intact organism, the effects of administration of various hormones at crucial periods of the host’s life cycle may result in carcinogenic effects because of profound lifelong changes in endocrine balance that can be induced by a single hormone administration. This latter phenomenon might be referred to as the inducement of unfavorable hormonal imbalance, and this imbalance has a procarcinogenic effect.


Breast Cancer Mammary Gland Anorexia Nervosa Corpus Luteum Pituitary Hormone 
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Albert Segaloff
    • 1
  1. 1.Section on Endocrine Research of the Richard W. Freeman Research InstituteAlton Ochsner Medical FoundationNew OrleansUSA

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