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Hormones and Mammary Carcinogenesis

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Breast Cancer:Advances in Research and Treatment, Vol. 2: Experimental Biology

Abstract

In the classic sense of carcinogenesis, such as that produced by ionizing radiation or “carcinogenic” hydrocarbons, hormones are probably not carcinogenic. They are either procarcinogens or cocarcinogens. In this sense, they produce more substrate either for initiation or for promotion by other substances, but of themselves they are probably not carcinogens. In the intact organism, the effects of administration of various hormones at crucial periods of the host’s life cycle may result in carcinogenic effects because of profound lifelong changes in endocrine balance that can be induced by a single hormone administration. This latter phenomenon might be referred to as the inducement of unfavorable hormonal imbalance, and this imbalance has a procarcinogenic effect.

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Authors and Affiliations

  1. Section on Endocrine Research of the Richard W. Freeman Research Institute, Alton Ochsner Medical Foundation, 1516 Jefferson Highway, New Orleans, Louisiana, 70121, USA

    Albert Segaloff

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  1. Albert Segaloff
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Editors and Affiliations

  1. University of Texas Health Science Center, San Antonio, Texas, USA

    William L. McGuire M.D.

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Segaloff, A. (1978). Hormones and Mammary Carcinogenesis. In: McGuire, W.L. (eds) Breast Cancer:Advances in Research and Treatment, Vol. 2: Experimental Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4673-0_1

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  • DOI: https://doi.org/10.1007/978-1-4757-4673-0_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4675-4

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