Diseases Affecting the Inner Blood-Retinal Barrier

  • Morton F. Goldberg

Abstract

The inner blood-retinal barrier (I-BRB) is affected by a surprising array of ocular diseases, often with deterioration of vision. These retinal vasculopathies can be classified12 within the following eight categories: stretching of the vascular wall; hypoxia; metabolic (chemical, physiologic, and pharmacologic) alterations; inflammatory processes; tapetoretinal dystrophies and retinoschisis; trauma; developmental vascular anomalies; and preretinal neovascularization. This report will provide clinical examples of diseases within each of these major pathogeneses. Frequently, the categories overlap, and may have an additive effect on disturbances of permeability. Thus, disruption of the I-BRB is often multifactorial, and a single disease affecting the retinal vasculature may be classified under more than one category. Diabetic retinopathy, for example, is such a disease, and, because of its complexity and prevalence, is discussed separately.

Keywords

Diabetic Retinopathy Fluorescein Angiography Retinitis Pigmentosa Retinal Vein Occlusion Cystoid Macular Edema 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Cunha-Vaz, J., Surv. Ophthalmol. 23: 279–296, 1979PubMedCrossRefGoogle Scholar
  2. 2.
    Archer, D.B., In Deutman, A.F. (ed.): New Developments in Ophthalmology, Nijmegen, 1975: Documenta Ophthalmologica Proceedings Series, vol. 7, The Hague, Dr. W. Junk by Pub., 1976, pp. 155–167.Google Scholar
  3. 3.
    Wise, G.N., Am. J. Ophthalmol. 79: 349–365, 1975.Google Scholar
  4. 4.
    Bellhorn, M.B., Friedman, A.H., Wise, G.N., and Henkind, P., Am. J. Ophthalmol. 79: 366–373, 1975.PubMedGoogle Scholar
  5. 5.
    Sumers, K.D., Jampol, L.M., Goldberg, M.F., and Huamonte, F.U., Arch. Ophthalmol. in press.Google Scholar
  6. 6.
    Tolentino, F.I., Schepens, C.L., and Freeman, H.M.: Vitreoretinal Disorders: Diagnosis and Management, Philadelphia, W. B. Saunders, 1976, p. 141.Google Scholar
  7. 7.
    Tolentino, F.I., and Schepens, C.L., Arch. Ophthalmol. 74: 78 1786, 1965.Google Scholar
  8. 8.
    Asdourian, G.K., Goldberg, M.F., Jampol, L., and Rabb, M., Arch. Ophthalmol. 95: 624–628, 1977.PubMedCrossRefGoogle Scholar
  9. 9.
    Goldberg, M.F., and Duke, J.R., Am. J. Ophthalmol. 66: 693–705, 1968.Google Scholar
  10. 10.
    Gass, J.D.M., Arch. Ophthalmol. 80: 550–568, 1968.Google Scholar
  11. 11.
    Archer, D.B., Ernest, J.T., and Newell, F.W., Trans. Am. Acad. Ophthalmol. Otolaryngol. 78:OP148–0P165, 1974.Google Scholar
  12. 12.
    Joondeph, H.C., and Goldberg, M.F., Am. J. Ophthalmol. 80: 253257, 1975.Google Scholar
  13. 13.
    Orth, D.H., and Patz, A., Surv. Ophthalmol. 22: 357–376, 1978.PubMedCrossRefGoogle Scholar
  14. 14.
    Hamilton, A.M., Kohner, E.M., Rosen, D., Bird, A.C., and Dollery, C.T., Br. J. Ophthalmol. 63: 377–387, 1979.PubMedCrossRefGoogle Scholar
  15. 15.
    Hockley, D.J., Tripathi, R.C., and Ashton, N., Br. J. Ophthalmol. 63: 393–411, 1979.PubMedCrossRefGoogle Scholar
  16. 16.
    Editorial, Br. J. Ophthalmol. 63: 375–376, 1979.CrossRefGoogle Scholar
  17. 17.
    Clemett, R.S., Br. J. Ophthalmol. 58: 548–554, 1974.Google Scholar
  18. 18.
    Goldberg, M.F., and Tso, M.O.M., Ophthalmic Surgery 10 (4): 89123, 1979.Google Scholar
  19. 19.
    Hayreh, S.S., Am. J. Ophthalmol. 72: 998–1011, 1971.PubMedGoogle Scholar
  20. 20.
    Hayreh, S.S., van Heuven, W.A.J., and Hayreh, M.S., Arch. Ophthalmol. 96: 311–323, 1978.PubMedCrossRefGoogle Scholar
  21. 21.
    Fujino, T., Curtin, V.T., and Norton, E.W.D., Arch. Ophthalmol. 81: 395–406, 1969.Google Scholar
  22. 22.
    Editorial, Br. J. Ophthalmol. 59: 1–2, 1975.CrossRefGoogle Scholar
  23. 23.
    Keith, N.M., Wagener, H.P., and Barker, N.W., Am. J. Med. Sci. 197: 332–343, 1939.Google Scholar
  24. 24.
    Garner, A., Ashton, N., Tripathi, R., Kohner, E.M., Bulpitt, C.J., and Dollery, C.T., Br. J. Ophthalmol. 59: 3–44, 1975.Google Scholar
  25. 25.
    Klein, M., Goldberg, M.F., and Cotlier, E., Ann. Ophthalmol. 7: 1213–1221, 1975.Google Scholar
  26. 26.
    van Heuven, W.A.J., Hayreh, M.S., and Hayreh, S.S., Trans. Ophthalmol. Soc. U.K. 97: 588–617, 1977.Google Scholar
  27. 27.
    Acacio, I., and Goldberg, M.F., Am. J. Ophthalmol. 75: 861–866, 1973.Google Scholar
  28. 28.
    Gass, J.D.M., Arch. Ophthalmol. 80: 535–549, 1968.PubMedCrossRefGoogle Scholar
  29. 29.
    Schatz, H., and Drake, M., Ophthalmology 86: 468–483, 1979.PubMedGoogle Scholar
  30. 30.
    Shakib, M., and Ashton, N., Br. J. Ophthalmol. 50: 325–384, 1966.PubMedCrossRefGoogle Scholar
  31. 31.
    Ashton, N., and Cunha-Vaz, J.G., Arch. Ophthalmol. 73: 211–223, 1965.PubMedCrossRefGoogle Scholar
  32. 32.
    Peyman, G.A., Bennett, T.O., and Vlchek, J., Ann. Ophthalmol. 7: 279–288, 1975.Google Scholar
  33. 33.
    Michels, R.G., and Maumenee, A.E., Am. J. Ophthalmol. 80: 379388, 1975.Google Scholar
  34. 34.
    Ryan, G.B., and Majno, G., Am. J. Pathol. 86: 183–276, 1977.Google Scholar
  35. 35.
    Simionescu, N., Simionescu, M., and Palade, G.E., J. Cell Biol. 70(2, pt. 2 ): 186a, 1976.Google Scholar
  36. 36.
    Perkins, E.S.: Uveitis and Toxoplasmosis. London, J. & A. Churchill, 1961, p. 85.Google Scholar
  37. 37.
    Aaberg, T.M., Cesarz, T.J., and Rytel, M.W., Am. J. Ophthalmol. 74: 407–415, 1972.Google Scholar
  38. 38.
    de Venecia, G., Zu Rhein, G.M., Pratt, M.V., and Kisken, W., Arch. Ophthalmol. 86: 44–57, 1971.PubMedCrossRefGoogle Scholar
  39. 39.
    Wyhinny, G.J., Typle, D.J., Guastella, F.R., and Vygantas, C.M., Am. J. Ophthalmol. 76: 773–781, 1973.PubMedGoogle Scholar
  40. 40.
    Minckler, D.S., McLean, E.B., Shaw, C.M., and Hendrickson, A., Arch. Ophthalmol. 94: 89–95, 1976.PubMedCrossRefGoogle Scholar
  41. 41.
    Naumann, G., Gass, J.D.M., and Font, R.L., Am. J. Ophthalmol. 65: 533–541, 1968.Google Scholar
  42. 42.
    Brown, R.M., and Mendis, U., Br. J. Ophthalmol. 57: 344–346, 1973.PubMedCrossRefGoogle Scholar
  43. 43.
    Spitznas, M., Meyer-Schwickerath, G., and Stephan, B., A. von Graefes Arch. klin. exp. Ophthalmol. 193: 73–85, 1975.Google Scholar
  44. 44.
    Duke-Elder, S. (ed.): System of Ophthalmology, vol. 10, Diseases of the Retina, London, Henry Kimpton, 1967, p. 249.Google Scholar
  45. 45.
    Crouch, E.R., Jr., and Goldberg, M.F., Arch. Ophthalmol. 93: 384–387, 1975.PubMedCrossRefGoogle Scholar
  46. 46.
    Martin, N.F., and Fitzgerald, C.R., Am. J. Ophthalmol. 88: 2831, 1979.Google Scholar
  47. 47.
    Jampol, L.M., Isenberg, S.J., and Goldberg, M.F., Am. J. Ophthalmol. 81: 583–589, 1976.PubMedGoogle Scholar
  48. 48.
    ffytche, T.J., Trans. Ophthalmol. Soc. U.K. 97: 457–461, 1977.PubMedGoogle Scholar
  49. 49.
    Willerson, D., Jr., Aaberg, T.M., and Reeser, F.H., Am. J. Ophthalmol. 84: 209–219, 1977.PubMedGoogle Scholar
  50. 50.
    Wise, G.N., Dollery, C.T., and Henkind, P.: The Retinal Circulation. New York, Harper & Row, 1971, p. 296.Google Scholar
  51. 51.
    Chester, G.H., Blach, R.K., and Cleary, P.E., Trans. Ophthalmol. Soc. U.K. 96: 151–157, 1976.PubMedGoogle Scholar
  52. 52.
    Maumenee, A.E., Am. J. Ophthalmol. 69: 1–27, 1970.PubMedGoogle Scholar
  53. 53.
    Kenyon, K.R., Pederson, J.E., Green, W.R., and Maumenee, A.E., Trans. Ophthalmol. Soc. U.K. 95: 391–397, 1975.PubMedGoogle Scholar
  54. 54.
    Schatz, H., Burton, T.C., Yannuzzi, L.A., and Rabb, M.F.: Interpretation of Fundus Fluorescein Angiography, St. Louis, C.V. Mosby, 1978, pp. 550–631.Google Scholar
  55. 55.
    Fishman, G.A., Goldberg, M.F., and Trautmann, J.C., Ann. Ophthalmol. 11: 21–27, 1979.PubMedGoogle Scholar
  56. 56.
    Gass, J.D.M., and Norton, E.W.D., Arch. Ophthalmol. 76: 646–661, 1966.Google Scholar
  57. 57.
    The Miami Study Group: Cystoid macular edema in aphakic and pseudophakic eyes. Am. J. Ophthalmol. 88: 45–48, 1979.Google Scholar
  58. 58.
    Miyake, K., Sugiyama, S., Norimatsu, I., and Ozawa, T., A. von Graefes Arch. klin. exp. Ophthalmol. 209: 83–88, 1978CrossRefGoogle Scholar
  59. 59.
    Fishman, G.A., Jampol, L.M., and Goldberg, M.F., Br. J. Ophthalmol. 60: 345–353, 1976.PubMedCrossRefGoogle Scholar
  60. 60.
    Green, J.L., Jr., and Jampol, L.M.: Br. J. Ophthalmol. 63: 368373, 1979.Google Scholar
  61. 61.
    Fishman, G.A., Maggiano, J.M., and Fishman, M., Arch. Ophthalmol. 95: 1993–1996, 1977.PubMedCrossRefGoogle Scholar
  62. 62.
    Gieser, D.K., Fishman, G.A., and Cunha-Vaz, J., Arch. Ophthalmol., in press.Google Scholar
  63. 63.
    Maumenee, A.E. In L’Esperance, F.A., Jr. (ed.): Current Diagnosis and Management of Chorioretinal Diseases, St. Louis, C.V. Mosby, 1977, pp. 287–294.Google Scholar
  64. 64.
    Kohner, E.M., Dollery, C.T., Henkind, P., Paterson, J.W., and Ramalho, P.S., Am. J. Ophthalmol. 63: 1748–1761, 1967.PubMedGoogle Scholar
  65. 65.
    Machemer, R., Am. J. Ophthalmol. 69: 27–38, 1970.PubMedGoogle Scholar
  66. 66.
    Apple, D.J., Wyhinny, G.J., Goldberg, M.F., Polley, E.H., and Bizzell, J.W., Arch. Ophthalmol. 94: 137–144, 1976.PubMedCrossRefGoogle Scholar
  67. 67.
    Apple, D.J., Goldberg, M.F., and Wyhinny, G., Am. J. Ophthalmol. 75: 595–609, 1973.PubMedGoogle Scholar
  68. 68.
    Noth, J.M., Vygantas, C., and Cunha-Vaz, J.G.F., Invest. Ophthalmol. Vis. Sci. 17: 1206–1209, 1978.PubMedGoogle Scholar
  69. 69.
    Amoils, S.P., and Honey, D.P., Arch. Ophthalmol. 82: 220–228, 1969.PubMedCrossRefGoogle Scholar
  70. 70.
    Gass, J.D.M.: Differential Diagnosis of Intraocular Tumors: A Stereoscopic Presentation. St. Louis, C.V. Mosby, 1974, pp. 247–264.Google Scholar
  71. 71.
    Archer, D., and Krill, A.E., Surv. Ophthalmol. 15: 384–400, 1971.Google Scholar
  72. 72.
    Tripathi, R., and Ashton, N., Br. J. Ophthalmol. 55: 289–301, 1971.Google Scholar
  73. 73.
    Goldberg, M.F., In Peyman, G.A., Apple, D.J., and Sanders, D.R. (eds.): Intraocular Tumors, New York, Appleton/Century/Crofts, 1977, pp. 219–234.Google Scholar
  74. 74.
    Haining, W.M., and Zweifach, P.H., Arch. Ophthalmol. 78: 475479, 1967.Google Scholar
  75. 75.
    Nicholson, D.H., Green, W.R., and Kenyon, K.R., Am. J. Ophthalmol. 82: 193–204, 1976.PubMedGoogle Scholar
  76. 76.
    Goldberg, M.F., in Lynn, J.R., Snyder, W.B., and Vaiser, A. (eds.): Diabetic Retinopathy, New York, Grune & Stratton, 1974, pp. 47–63.Google Scholar
  77. 77.
    Archer, D.B., Trans. Ophthalmol. Soc. U.K. 96: 471–493, 1976.PubMedGoogle Scholar
  78. 78.
    Archer, D.B., Trans. Ophthalmol. Soc. U.K. 97: 449–456, 1977.PubMedGoogle Scholar
  79. 79.
    Henkind, P., Am. J. Ophthalmol. 85: 297–301, 1978.Google Scholar
  80. 80.
    Galinos, S.O., Asdourian, G.K_, Woolf, M.B., Goldberg, M.F., and Busse, B.J., Arch. Ophthalmol. 93: 524–530, 1975.PubMedCrossRefGoogle Scholar
  81. 81.
    Goldberg, M.F., Trans. Am. Acad. Ophthalmol. Otolaryngol. 75: 532–556, 1971.PubMedGoogle Scholar
  82. 82.
    Goldberg, M.F., In Bergsma, D., Bron, A.J., and Cotlier, E. (eds.): The Eye and Inborn Errors of Metabolism: Birth Defects, vol. 12, no. 3, New York, Alan R. Liss, 1976, pp. 475–515.Google Scholar
  83. 83.
    Kimura, T., Jpn. J. Ophthalmol. 18: 403–417, 1974.Google Scholar
  84. 84.
    Kimura, T., Chen, C.H, and Patz, A., In The Association for Research in Vision and Ophthalmology, Spring Meeting, Sarasota, Fl., 1976 Abstracts, p. 87.Google Scholar
  85. 85.
    Taniguchi, Y., Jpn. J. Ophthalmol. 20: 19–31, 1976.Google Scholar
  86. 86.
    Goldberg, M.F., and Tso, M.O.M., Ophthalmology 85: 1028–1041, 1978.PubMedGoogle Scholar
  87. 87.
    Kenyon, K.R., and Michels, R.G., Am. J. Ophthalmol. 83: 815823, 1977.Google Scholar
  88. 88.
    Goldberg, M.F., Trans. Am. Acad. Ophthalmol. Otolaryngol. 83: OP409–OP431, 1977.Google Scholar
  89. 90.
    Gass, J.D.M., Arch. Ophthalmol. 80: 583–591, 1968.PubMedCrossRefGoogle Scholar
  90. 91.
    Patz, A., Schatz, H., Berkow, J.W., Gittelsohn, A.M., and Ticho, U., Trans. Am. Acad. Ophthalmol. Otolaryngol. 77:OP34-Google Scholar
  91. 92.
    Myers, F.L., Davis, M.D., and Magli, Y.L., In Goldberg, M.F., and Fine, S.L. (eds.): Symposium of the Treatment of Diabetic Retinopathy, Airlie House, Warrenton, Va., 1968, Washington, D.C., U.S. Public Health Service Publication No. 1890, Superintendent of Documents, 1968, pp. 81–85.Google Scholar
  92. 93.
    Michaelson, I.C., In Regnault, F., and Duhault, J. (eds.): Colloquium on Cellular and Biochemical Aspects in Diabetic Retinopathy, Paris, France, 1978: INSERM Symposium No. 7, Amsterdam, North-Holland, 1978, pp. 257–275.Google Scholar
  93. 94.
    Ashton, H., Adv. Ophthalmol. 8: 1–84, 1958.Google Scholar
  94. 95.
    Wise, G.N., Dollery, C.T., and Henkind, P.: The Retinal Circulation, New York, Harper & Row, 1971, pp. 421–453.Google Scholar
  95. 96.
    Ashton, N., In Amalric, P. (ed.): International Symposium on Fluorescein Angiography, Albi, 1969, Basel, S. Karger, 1971, pp. 334–345.Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Morton F. Goldberg
    • 1
  1. 1.Eye and Ear InfirmaryUniversity of IllinoisChicagoUSA

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