Acute Hypertension and Experimental Diabetes: Evaluation of their Effects on Blood-Ocular Barriers

  • A. M. Laties
  • P. A. Grimes
  • S. I. Rapoport


For the past several years we have been engaged in a series of studies on the effects of stress on the blood-ocular barriers. A variety of stresses have been studied — including osmotic shock,1 acute hypertension,2 drug reactivity,3 experimental diabetes,45 and carbon dioxide inhalation.6 For the measurement of barrier status, chief reliance has been placed on the localization of fluorescent dyes in freeze-dried tissue by darkfield microscopy. When appropriate, brains of the same animals have also been evaluated. In special instances, electron microscopy after the prior administration of horseradish peroxidase has been performed.


Evans Blue Experimental Diabetes Central Retinal Artery Mural Cell Retinal Blood Vessel 
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  1. 1.
    Laties, A.M. and Rapoport, S.: Arch. Ophthalmol. 94: 1086–1091, 1976.PubMedCrossRefGoogle Scholar
  2. 2.
    Laties, A.M., Rapoport, S.I. and McGlinn, A.: Arch. Ophthalmol. 97: 1511–1514, 1979.PubMedCrossRefGoogle Scholar
  3. 3.
    Laties, A.M., Neufeld, A.H., Vegge, T. and Sears, M.L.: Arch. Ophthalmol. 94: 1966–1971, 1976.PubMedCrossRefGoogle Scholar
  4. 4.
    Kirber, W.M., Nichols, C.W., Grimes, P.A., Winegrad, A.I., and Laties, A.M.: (In press, Arch. Ophthalmol.).Google Scholar
  5. 5.
    Grimes, P.A. and Laties, A.M.: (In press, Exp. Eye Res.).Google Scholar
  6. 6.
    Rapoport, S.I., Fredericks, W.R. and Laties A.M.: (In press Exp. Eye Res.).Google Scholar
  7. 7.
    Hogan, M.J., Alvarado, J.A. and Weddell, J.E.: HISTOLOGY OF THE HUMAN EYE. W.B. Saunders Co., Philadelphia, 1971.Google Scholar
  8. 8.
    Cogan, D.G., Kuwabara, T.: Ocular microangiopathy in diabetes, in Kimura, S. and Caygill, W.M. (eds.): VASCULAR COMPLICATIONS OF DIABETES MELLITUS. St. Louis, C.V.Mosby Co., 1967, pp. 53–63.Google Scholar
  9. 9.
    Burnside, B. and Wallow, I., personal communication, 1978.Google Scholar
  10. 10.
    Cunha-Vaz, J., Faria DeAbreu, J.R., Campos, A.J. and Figo, G.M.: Brit. J. Ophthalmol. 59: 649–656, 1975.CrossRefGoogle Scholar
  11. 11.
    Krupin, T., Waltman, S.R., Oestrich, C., Santiago, J., Ratzan, S., Kilo, C. and Becker, B.: Arch.Ophthalmol. 96: 812–814, 1978.CrossRefGoogle Scholar
  12. Junod, A., Lambert, A.E., Stauffacher, W. and Renold, A.E.: J. Clin. Invest. 48:2129–2139, 1969.Google Scholar
  13. 14.
    Karnovsky, M.J.: J. Cell Biol. 35: 213–236, 1967.CrossRefGoogle Scholar
  14. 15.
    Lerche, W.: Die kapillarisierung der menschlichen retina in Rohen, J.W. (ed.): EYE STRUCTURE II. SYMPOSIUM. Schattauer Verlag, Stuttgart, 1965, pp. 121–128.Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • A. M. Laties
    • 1
    • 2
  • P. A. Grimes
    • 1
    • 2
  • S. I. Rapoport
    • 1
    • 2
  1. 1.Department of Ophthalmology, Scheie Eye Institute, School of MedicineUniversity of PennsylvaniaUSA
  2. 2.Laboratory of Neurosciences, National Institute on Aging, Gerontology Research CenterBaltimore City HospitalsUSA

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