Pathology of the Blood-Retinal Barrier

  • Mark O. M. Tso


The primary sites of the blood-retinal barrier are the endothelium of the retinal capillary and the retinal pigment epithelium (RPE). Yet, these two types of cells are very different. Embryologically, the endothelium of the retinal capillary is of mesodermal origin, but the RPE derives from neuroectoderm. Structurally, the retinal capillary is of the continuous type.1 The apices of the endothelial cells of the retinal capillary are in direct contact with the bloodstream, and the villi of the endothelial cells are believed to be specialized for transport function. Endothelial cells are joined to each other by a zonula occludens type of cell junction. In contrast, the RPE is not in direct contact with the bloodstream. Nutrients from the choroidal circulation pass through the fenestrated endothelium of the choriocapillaris and Bruch’s membrane to reach the base of the RPE. The basal plasmalemma of the RPE cells develops numerous infoldings to facilitate the transport function. The RPE cells are joined to each other by zonula adherens and zonula occludens types of cell junctions. Physiologically, while the endothelial cells are specialized for transport function, the RPE serves as the metabolic warehouse for the retina and provides support for photoreceptor cells in addition to its function as the blood-retinal barrier for the outer retina.


Retinal Pigment Epithelium Retinal Pigment Epithelium Cell Photoreceptor Cell Cell Junction Subretinal Space 
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  1. 1.
    Rapoport, S.: Blood-Brain Barrier in Physiology and Medicine. Raven Press, York, New York. 1976, p. 212.Google Scholar
  2. 2.
    Deem, C.W., Futterman, S., and Kalina, R.E.: Invest. Ophthalmol. 13: 580, 1974.PubMedGoogle Scholar
  3. 3.
    Tso, M.O.M., and Albert, D 1972. Arch. Ophthalmol. 88:27–38Google Scholar
  4. 4.
    Tso, M.O.M., and Shih, C.Y.: Invest. Ophthalmol. 16: 381–392, 1977.Google Scholar
  5. 5.
    Wallow, I.H.L., and Engerman, R.L.: Invest. Ophthalmol. 16: 447, 1977.Google Scholar
  6. 6.
    Shiose, Y.: Jap. J. Ophthalmol. 14: 73, 1970.Google Scholar
  7. 7.
    Tso., M.O.M., Shih, C.Y., and Patz, A.: ARVO Meeting, Sarasota, Florida, 1977.Google Scholar
  8. 8.
    Tso, M.O.M., and Shih, C.Y.: Exp. Eye Res. 23: 209–216, 1976.PubMedCrossRefGoogle Scholar
  9. 9.
    Tanigushi, Y., and Sameshima, M.: Acta Soc. Ophthalmol. Jpn. 75: 1685, 1971.Google Scholar
  10. 10.
    Goldberg, M.F., and Tso, M.O.M.: Ophthalmol. (AA00) 85: 1028 1041, 1978.Google Scholar
  11. 11.
    Taniguchi, Y.: Jpn. J. Ophthalmol. 20: 19, 1976.Google Scholar
  12. 12.
    Ashton, N., Tripathi, B., and Kight, G.: Exp. Eye Res. 14: 221, 1972.PubMedCrossRefGoogle Scholar
  13. 13.
    Tso, M.O.M., Fine, B.S., and Zimmerman, L.E.: Am. J. Ophthalmol. 73: 686, 1972.Google Scholar
  14. 14.
    Tso, M.O.M.: Invest. Ophthalmol. 12: 17, 1973.PubMedGoogle Scholar
  15. 15.
    Wallow, I.H.L., and Tso, M.O.M.: Am. J. Ophthalmol. 73: 914, 1972.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Mark O. M. Tso
    • 1
  1. 1.University of Illinois Eye and Ear InfirmaryChicagoUSA

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