Whole Blood Serotonin and Family Background Relate to Male Violence

  • Terrie Moffitt
  • Avshalom Caspi
  • Paul Fawcett
  • Gary L. Brammer
  • Michael Raleigh
  • Arthur Yuwiler
  • Phil Silva
Part of the Nato ASI Series book series (NSSA, volume 292)

Abstract

Clinical and animal studies suggest that brain serotonergic systems may regulate aggressive behavior. However, the serotonin/violence relation has not been assessed at the epidemiological level. For study of an epidemiological sample we examined blood serotonin; certain physiological and behavioral data suggested that it might serve as an analogue marker for brain serotonergic function. Whole blood serotonin was measured in a representative birth cohort of 781 21-year-old women (48%) and men (52%). Violence was measured using cumulative court conviction records and participant’s self-reports. Potential intervening factors addressed were: gender, age, diurnal variation, diet, psychiatric medications, illicit drug history, season of phlebotomy, plasma tryptophan, platelet count, body mass, suicide attempts, psychiatric diagnoses, alcohol and tobacco dependence, socio-economic status, IQ, and overall criminal offending. Whole blood serotonin related to violence among men but not women. Violent men’s mean serotonin level was .56 SD above the mean of nonviolent men. The finding was specific to violence, as opposed to general crime, and it was robust across two different methods of measuring violence. Together, the intervening variables accounted for 25% of the relation between serotonin and violence. Developmental context interacted significantly with serotonin; serotonin was linked to violence primarily among men who grew up in families with little cohesion and much conflict. To our knowledge, this is the first demonstration that altered blood serotonin concentration is related to violence in the general population, and that the relation may depend on family origins.

Keywords

Tobacco Dependence Biological Psychiatry Violent Offender Male Violence Study Member 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Terrie Moffitt
    • 2
  • Avshalom Caspi
    • 2
  • Paul Fawcett
    • 3
  • Gary L. Brammer
    • 4
  • Michael Raleigh
    • 5
  • Arthur Yuwiler
    • 4
  • Phil Silva
    • 1
  1. 1.University of Otago Medical SchoolOtegoNew Zealand
  2. 2.University of WisconsinMadisonUSA
  3. 3.University of Otago School of PharmacyOtegoNew Zealand
  4. 4.West Los Angeles VA Medical CenterLos AngelesUSA
  5. 5.UCLA School of MedicineLos AngelesUSA

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