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Serotonin and Human Violence

Do Environmental Mediators Exist?

  • Chapter
Biosocial Bases of Violence

Part of the book series: Nato ASI Series ((NSSA,volume 292))

Abstract

The purpose of this chapter is to review evolving evidence for the possibility of environmental mediators of relationships between serotonin and violence in human children and adolescents. This chapter does not ask whether there are environmental mediators of violence - a variety of evidence suggests that environmental mediation of violence occurs (Tolan & Guerra 1994) and that interactions between biology and environmental events increase the risk of crime (Raine et al., 1994, 1996). Rather this paper focuses upon the possibility of environmental mediators of the relationship between serotonin and violence.

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References

  • Aman, M.G., Kern, R.A., McGee, D. E., & Arnold, L.E. (1993). Fenfluramine and methylphenidate in children with mental retardation and ADHD: Clinical and side effects. Journal of American Academy of Child Adolescent Psychiatry, 32(4), 851–S59.

    Google Scholar 

  • Anderson, C. A. (1987). Temperature and aggression: effects on quarterly, yearly, and city rates of violent and nonviolent crime. Journal of Pers Sociology and Psychology, 52, 1161–73.

    Google Scholar 

  • Arendt, J., Wirz-Justice, A., & Bradtke, J, (1977). Annual rhythm of serum melatonin in man. Neuroscience Letters, 7: 327–330.

    Google Scholar 

  • Arora, R.C., Kregel, L., & Meltzer, H. (1984). Transsynaptic control of gene expression. Annual Review of Neuroscience, 16: 17–29.

    Google Scholar 

  • Asberg, M., Traskman, L., & Thoren, P. (1976). 5-HIAA in the cerebrospinal fluid: a biochemical suicide predictor? Archives of General Psychiatry, 33:1193–7.

    PubMed  Google Scholar 

  • Asberg, M., Thoren, L., & Traskman, P. (1976a). Serotonin depression: a biochemical subgroup within affective disorders. Science, 191:478–80

    PubMed  Google Scholar 

  • Asberg, M., Schalling, D., Traskman-Bendz, L., & Wagner., A. (1987). Psychobiology of suicide, impulsivity and related phenomena. In Psychopharmacology: The Third Generation of Progress. H.Y. Meltzer (Ed.). Raven Press, New York.

    Google Scholar 

  • Bernstein, I., Williams, L., & Ramsay, M. (1983). The expression of aggression in old world monkeys. International Journal of Primatology, 4: 113–124.

    Google Scholar 

  • Blennow, K., Wallin, A., Gottfries, C.G., Karlsson, I., Mansson, J.E., Skoog, I., Wikkelson, C., & Svennerholm, L. (1993) Cerebrospinal fluid monoamine metabolites in 114 healthy individuals 18–88 years of age. European Neuropsychopharmacology, 3(1):55–61.

    PubMed  Google Scholar 

  • Brewerton, T.D., Berrettini, W.H., Nurnberger, J.I., & Linnoila, M. (1988). Analysis of seasonal fluctuations of CSF monoamine metabolites and neuropeptides in normal controls: Findings with 5-HIAA and HVA. Psychiatry Research, 23:257–265.

    PubMed  Google Scholar 

  • Brewerton, T.D., Flament, M.F., Rapoport, J.L., & Murphy, D.L. (1993). Seasonal effects on platelet 5-HT content in patients with OCD and controls. Archives of General Psychiatry, 50(5):409.

    PubMed  Google Scholar 

  • Brown, G. L., Goodwin, F.K., Ballenger, J.C., Goyer, P.F., & Major, L.F. (1979). Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Research, 1:131–139.

    PubMed  Google Scholar 

  • Brown, G.L., Ebert, M.H., Goyer, P.F., Jimerson, D.C., Klein, W.J., Bunney, W.E., & Goodwin, F.K. (1982). Aggression, suicide, and serotonin: Relationships to CSF amine metabolites. American Journal of Psychiatry, 139:741–746.

    PubMed  Google Scholar 

  • Brown, G.L., Kline, W., Goyer, P., Minichello, M., Kruesi, M., & Goodwin, F.K. (1986). Relationship of childhood characteristics to cerebrospinal fluid 5-hydroxyindoleacetic acid in aggressive adults. In C Shagass, RC Josiassen, WH Bridger, KJ Weiss, D Stoff, GM Simpson (Eds.) Biological Psychiatry. (chap 7. pp.l77–179). New York: Elsevier Science Publishing.

    Google Scholar 

  • Brown, G.L., & Linnoila, M.I. (1990). CSF serotonin metabolite (5-HIAA) studies in depression, impulsivity, and violence. Journal of Clinical Psychiatry, 51:31–41.

    PubMed  Google Scholar 

  • Castellanos, F.X., Elia, J., Kruesi, M.J., Gulotta, C.S., Mefford, I.N., Potter, W.Z., Ritchie, G. F., & Rapoport, J.L. (1994) Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder. Psychiatry Research, 52(3):305–316.

    PubMed  Google Scholar 

  • Chamberlain, B., Ervin, F.R., Pihl, R.O., & Young, S.N. (1987). The effect of raising or lowering tryptophan levels aggression in vervet monkeys. Pharmacology Biochemical Behavior, 28:503–510.

    Google Scholar 

  • Clarke, A.S., Kammerer, C.M., George, K.P., Kupfer, D.J., McKinney, W.T., Spence, M.A., & Kraemer, G.W. (1995) Evidence for heritability of biogenic amine levels in the cerebrospinal fluid of rhesus monkeys. Biological Psychiatry, 38 (9):572–577.

    Google Scholar 

  • Cleare, A.J., & Bond, A.J. (1994, December). Effects of alterations in plasma tryptophan levels on aggressive feelings [Letter to the editor]. Archives of General Psychiatry. 51:1004–1005.

    PubMed  Google Scholar 

  • Coccaro, E. F., Siever, L.J., Klar, H.M., Maurer, G., Cochrane, K., Cooper, T.B., Mohs, R.C., & Davis, K.L. (1989). Serotonergic studies in patients with affective and personalty disorders: Correlates with suicidal and impulsive aggressive behavior. Archives General Psychiatry, 46(7):587–99.

    Google Scholar 

  • Coccaro, E.F., Kavoussi, R.J., & Lesser, J.C. (1992). Self-and other-directed human aggression: The role of the central serotonergic system. International Clinical Psychopharmacology, 6, Suppl. (6) 70–83.

    PubMed  Google Scholar 

  • Coccaro, E.F., Kavoussi, R.J., Sheline, Y.I., Lish, J.D., & Czemasky, J.G. (1996). Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Archives of General Psychiatry, 53:531–536.

    PubMed  Google Scholar 

  • Cohen, D.J., Caparulo, B.K., Shaywitz, B.A., & Bower, M.B.J. (1977). Dopamine and serotonin metabolism in neuropsychiatrically disturbed children: CSF homovanillic acid and 5-hydroxyindoleacetic acid. Archives of General Psychiatry, 34:545–550.

    PubMed  Google Scholar 

  • Cook, E.H., Anderson, G.M., Heninger, G.R., Fletcher, K.E., et al. (1992). Tryptophan loading in hyperserotonemic and normoserotonemic adults. Biological Psychiatry, 31:525–8.

    PubMed  Google Scholar 

  • Cook, E., & Kruesi, M.J.P. (in press). Neurochemical measures. In D. Shaffer, J. Richters (Eds.) Assessment and Diagnosis in Child Psychopathology. Second Edition.

    Google Scholar 

  • Czernansky, J.G., Faull, K.F., & Pfefferbaum, A. (1988). Seasonal changes in CSF monoamine metabolites in psychiatric patients: What is the source? Psychiatry Research, 25:361–363.

    Google Scholar 

  • Donnelly, M., Rapoport, J.L., Potter, W.Z., Oliver, J., Keysor, C.S., & Murphy, D.L. (1989). Fentluramine and dextroamphetamine treatment of childhood hyperactivity. Archives of General Psychiatry, 46:205–212.

    PubMed  Google Scholar 

  • Durkheim, E. (1952). Suicide: A study in sociology (J.A. Spaulding & C. Simpson. Trans.). London: Routledge and Kegan Paul. (Original work published in 1897)

    Google Scholar 

  • Egrise, D., Rubenstein, M., Schoutens, A., Cantraine, F., & Mendelewicz, J. (1986). Seasonal variation of platelet serotonin uptake and 3H-imipramine binding in normal and depressed subjects. Biological Psychiatry, 21:283–293.

    PubMed  Google Scholar 

  • Eison, A.S., Yocca, F. D., & Gianutsos, G. (1988). Noradrenergic denervation alters serotonin2-mediates behavior but not serotonin2 receptor number in rats: modulatory role of beta adrenergic receptors. Journal of Pharmacologic Experimental Therapy, 246:571–577.

    Google Scholar 

  • Engleberg, H. (1992). Low serum cholesterol and suicide. Lancet, 339:727–729.

    Google Scholar 

  • Faustman, W.O., Ringo, D.L., & Faull, K.F. (1993). An association between low level of 5-HIAA and HVA in cerebrospinal fluid and early mortality in a diagnostically mixed psychiatric sample. British Journal of Psychiatry, 163:519–21.

    PubMed  Google Scholar 

  • Fernstrom, J.D., & Wurtman, R.J. (1972). Brain serotonin content: Physiological regulation by plasma neutral amino acids. Science, 178:414–416.

    PubMed  Google Scholar 

  • Garelis, E., Young, S.N., Lal, S., Sourkes, T.L. (1974). Monoamine metabolites in lumbar CSF: The question of their origin in relation to clinical studies. Brain Research, 79: 1–8.

    PubMed  Google Scholar 

  • Ghaziuddin, N., & Alessi, N. (1992). An open clinical trial of trazodone in aggressive children. Journal of Child and Adolescent Psychopharmacology, 2 291–298.

    PubMed  Google Scholar 

  • Gedye, A. (1991). Buspirone alone or with serotonergic diet reduced aggression in a developmentally disabled adult. Biological Psychiatry, 30:88–91.

    PubMed  Google Scholar 

  • Golden, R.N., Gilmore, J.H., Corrigan, M.H., Ekstrom, R.D., Knight, B.T., & Garbutt, J.C. (1991). Serotonin, suicide and aggression: clinical studies. Journal of Clinical Psychiatry, 52, supp1:61–69.

    PubMed  Google Scholar 

  • Greendyke, R.M., & Kanter, D. (1986). Therapeutic effects of pindolol on behavioral disease: A double blind study. Journal of Clinical Psychiatry, 47(8): 423–426.

    PubMed  Google Scholar 

  • Greendyke, R.M., Kanter, D.R., Schuster, D. B., Verstraete, S., & Wooton, J.A. (1986). Propranolol treatments of assaultive patients with organic brain disease. Journal of Nervous and Mental Disease, 174(5):290–294.

    PubMed  Google Scholar 

  • Halperin, J.M., Vanshdeep, S., Siever, L.J., Schwartz, S.T., Matier, K., Wornell, G., & Newcorn, J.H. (1994). Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. American Journal of Psychiatry, 151:243–248.

    PubMed  Google Scholar 

  • Heninger, G.R., Delgado, P.L., Charney, D.S., Price, L.H., & Aghajanian, G.K. (1992). Tryptophan deficient diet and amino acid drink deplete plasma tryptophan and induce a relapse of depression in susceptible patients. Joumal of Chemical Neuroanatomy, 5:347–8

    Google Scholar 

  • Higley, J.D., Mehlman, P.T., Taub, D.M., Higley, S.B., Suomi, S.J., Vickers, J.H., & Linnoila, M. (1992): Cerebrospinal tluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Archives of General Psychiatry, 49:436–441.

    PubMed  Google Scholar 

  • Higley, J.D., Suomi, S.J., & Linnoila M (1992a): A longitudinal assessment of CSF monoamine metabolite and plasma cortisol concentrations in young rhesus monkeys. Biological Psychiatry, 32: 127–145.

    PubMed  Google Scholar 

  • Higley, J.D., Mehlman, P.T., Higley, S.B., Fernald, B., Vickers, J., Lindell, S.G., Taub, D.M., Suomi, S.J., & Linnoila, M. (1996). Excessive mortality in young free-ranging male nonhuman primates with low cerebrospinal tluid 5-hydroxyindoleacetic acid concentrations. Archives of General Psychiatry, 53:537–543.

    PubMed  Google Scholar 

  • Huesmann, L.R., Eron, L.D., Lefkowitz, M.M., & Walder, L.O. (1984). Stability of aggression overtime and generations. Developmental Psychology, 20: 1120–1134.

    Google Scholar 

  • Jacobsen, T., Edelstein, W., & Hofmann, V. (1994). A longitudinal study of the relation between representations of attachment in childhood and cognitive functioning in childhood and adolescence. Developmental Psychology, 30(1): 112–14.

    Google Scholar 

  • Jacobsen, T., Hofmann, V. (in press). Children’s attachment representations: Longitudinal relations to school behavior and academic competency in middle childhood and adolescence. Developmental Psychology.

    Google Scholar 

  • Kaplan, J.R., Manuck, S.B., Shively, C. (1991). The effects of fat and cholesterol on social behavior in monkeys. Psychosomatic Medicine, 53:634–642.

    PubMed  Google Scholar 

  • Kaplan, J.R., Shively, C.A., Fontenot, M.B., Morgan, T.M., Howell, S.M., Manuck, S.B., Muldoon, M.F., & Mann, J.J. (1994). Demonstration of an association among dietary cholesterol, central serotonergic activity, and social behavior in monkeys. Psychosomatic Medicine, 56(6):479–84.

    PubMed  Google Scholar 

  • Koponen, H.J., Lepola, U., Leinonen, E. (1994). A long-term follow-up study of cerebrospinal tluid 5-hydroxyindoleacetic acid in delirium. European Archives of Psychiatry and Clinical Neuroscience, 244 (3): 131–134.

    Google Scholar 

  • Kraemer, G.W., & Clarke, A.S. (in press). Social attachment, brain function and aggression. Annals of New York Academy of Science.

    Google Scholar 

  • Kruesi, M.J.P., Linnoila, M., Rapoport, J.L., Brown, G.C., & Petersen, R. (1985). Carbohydrate craving, conduct disorder and low CSF 5-HIAA. Psychiatry Research, 16:83–86.

    PubMed  Google Scholar 

  • Kruesi, M.J.P., Swedo, S.E., Hamburger, S.D., Potter, W.Z., & Rapoport, J.L. (1988). Concentration gradient of CSF monoamine metabolites in children and adolescents. Biological Psychiatry, 24:507–514.

    PubMed  Google Scholar 

  • Kruesi, M.J.P. (1989). Cruelty to animals and CSF 5-HIAA. Psychiatry Research, 28, 115–116.

    PubMed  Google Scholar 

  • Kruesi, M.J.P., Rapoport, J.L., Hamburger, S., Hibbs, E., Potter, W.Z., Lenane, M., & Brown, G.L. (1990). Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Archives of General Psychiatry, 47,419–426.

    PubMed  Google Scholar 

  • Kruesi, M.J.P., Hibbs, E. D., Zahn, T.P., Keysor, C.S., Hamburger, S.D., Bartko,.J., & Rapoport, J.L. (1992). A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders. Prediction by cerebrospinal tluid 5-hydroxyindoleacetic acid, homovanillic acid, and autonomic measures. Archives of General Psychiatry, 49, 429–435.

    PubMed  Google Scholar 

  • Kruesi, M.J.P., & Lelio, D.F. (1996). Disorders of conduct and behavior. In J. Weiner (Ed.). Diagnosis and Psychopharmacology of Childhood and Adolescent Disorders (pp. 401–447) Second Edition. New York: John Wiley & Sons, Inc.

    Google Scholar 

  • Kuperman, S., & Stewart, M.A. (1987). Use of propranolol to decrease aggressive outbursts in younger patients. Psychosomatics, 28(6), 315–319.

    PubMed  Google Scholar 

  • Langlais, P.J., Walsh, F. X., Bird, E.D. & Levy, H.L. (1985). Cerebrospinal fluid neurotransmitter metabolites in neurologically normal infants and children. Pediatrics, 75:580–86.

    PubMed  Google Scholar 

  • Lester, D. (1995). The concentration of neurotransmitter metabolites in the cerebrospinal fluid of suicidal individuals; a meta-analysis. Pharmacopsychiatry, 28(2):45–50.

    PubMed  Google Scholar 

  • Linkowski, P., Martin, F., & De Maertelaer, V. (1992). Effect of some climatic factors on violent and non-violent suicides in Belgium. Journal of Effective Disorders, 25(3); 161–6

    Google Scholar 

  • Linnoila, M., Virkkunen, M., Scheinin, M., Nuutila, A., Rimon, R., & Goodwin, F.K. (1983). Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from non impulsive violent behavior. Life Sciences, 33:2609–2614.

    PubMed  Google Scholar 

  • Linnoila, V.M., & Virkkunen, M. (1992). Aggression, suicidality, and serotonin. Journal of Clinical Psychiatry, 53 (Suppl.), 36–51.

    Google Scholar 

  • Lucas, A., Morley, R., Cole, T.J., Lister, G., & Leeson-Payne, C. (1992). Breast milk and subsequent intelligence quotient in children born preterm. Lancet, 339;261–4.

    PubMed  Google Scholar 

  • Lucas, A. Morley, R., Cole, T.J., & Gore, S.M. (1994). A randomised multicentre study of human milk versus formula and later development in preterm infants. Arch Dis Child Fetal Neonatal Ed, 70, 141–6.

    Google Scholar 

  • Maes, M., Scharpe, S., Verkerk, R., D’Hondt, P., Peeters, D., Cosyns, P., Thompson, P., De Meyer, F., Wauters, A., & Neels, H. (1995). Seasonal Variation in Plasma L-Tryptophan Availability in Healthy Volunteers. Archives of General Psychiatry, 52:937–946.

    PubMed  Google Scholar 

  • Mann, J., McBride, P., Anderson, G., & Mieczkowski, T. (1992). Platelet and whole blood serotonin content in depressed inpatients; Correlations with acute and life-time psychopathology. Biological Psychiatry, 32,243–257.

    PubMed  Google Scholar 

  • Mann, J.J., McBride, P.A., Brown, R.P., Linnoila, M., Leon, A.C., DeMeo, M., Mieczkowski, T., Myers, J.E., & Stanley, M. (1992a). Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients. Archives of General Psychiatry, 49(6):442–6

    PubMed  Google Scholar 

  • Markowitz, P. (1992). Effect of fluoxetine on self-injurious behavior in the developmentally disabled; A preliminary study. Journal of Clinical Psychopharmacology, 12(1), 27–31.

    PubMed  Google Scholar 

  • Matthews-Ferrari, K., & Karroum, N. (1992). Metoprolol for aggression. In; Letters to the editor. Journal of the American Academy of Child and Adolescent Psychiatry, 31(5), 994.

    PubMed  Google Scholar 

  • Mefford, I.N., Ward, M.M., Miles, L., Taylor, B., Chesney, M.A., Keegan, D.L., & Barchas, J.D. (1981). Determination of plasma catecholamines and free 3,4-dihidroxyphenolacetic acid in continuously collected human plasma by high performance liquid chromatography with electrochemical detection. Life Science, 28, 477–483.

    Google Scholar 

  • Mehlman, P.T., Higley, J.D., Faucher, I., Lilly, A.A., Taub, D.M., Vickers, J., Suomi, SJ., Linnoila, M. (1994). Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. American Journal of Psychiatry, 151; 1485–91.

    PubMed  Google Scholar 

  • Mehlman, P.T., Higley J.D., Faucher, I., Lilly, A.A., Taub, D.M., Vickers, J., Suomi, S.J., Linnoila, M. (1995). Correlation of CSF 5-HlAA concentration with sociality and the timing of emigration in free-ranging primates. American Journal of Psychiatry, 152;901–13.

    Google Scholar 

  • Michael, R.P., & Zumpe, D. (1983). Annual rhythms in human violence and sexual aggression in the United States and the role of temperature. Social Biology, 30(3):263–78.

    PubMed  Google Scholar 

  • Michael, R.P., & Zumpe, D. (1983a). Sexual violence in the United States and the role of season. American Journal of Psychiatry, 140;883–6.

    PubMed  Google Scholar 

  • Michael, R.P., & Zumpe, D. (1986). An annual rhythm in the battering of women. American Journal of Psychiatry. 143 (5);631–40.

    Google Scholar 

  • Moffitt, T. E. (1993). The neuropsychology of conduct disorder. Development and Psychopathology, 5; 135–151.

    Google Scholar 

  • Moffitt, T., Caspi, A., Fawcett, P., Brammer, G.L., Raleigh, M., Yuwiler, A., & Silva, P. (in press). Whole blood serotonin and family background relate to male violence. In A. Raine, D. F31Tington, P. Brennan. & S.A. Mednick (Eds.), Biosocial bases of violence. New York: Plenum Publishing.

    Google Scholar 

  • Moss, H.B., Yao, J.K., & Panzak, G.L. (1990). Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse. Biological Psychiatry, 28;325–338.

    PubMed  Google Scholar 

  • Muldoon, M.F., Manuck, S.B., Matthews, K.A. (1990). Lowering cholesterol concentrations and normality; A quantitative review of primary prevention trials. British Medical Journal, 301:309–314.

    PubMed  Google Scholar 

  • Neaton J.D., Blackburn, H., Jacobs, D., et al. (1992). Serum cholesterol level and mortality findings for men screened in the multiple risk factor intervention trial. Archives of Internal Medicine, 152; 1490–1500.

    PubMed  Google Scholar 

  • Nordin, C., Swedin, A., Zachau, A. (1992). CSF 5-HIAA and Atmospheric Pressure. Biological Psychiatry, 31:644–645.

    PubMed  Google Scholar 

  • Nordstrom, P., Samuelsson, M., Asberg, M., Traskman-Bendz, L., Nordin, C., & Bertilsson, L. (1994). CSF 5-HIAA predicts suicide risk after attempted suicide. Suicide and Life Threatening Behavior, 24(1); 1–9.

    PubMed  Google Scholar 

  • Olweus, D. (1979). Stability of aggressive reaction patterns in males: a review. Psychological Bulletin, 86;852–15.

    PubMed  Google Scholar 

  • O’Neill, M., Page, N., & Adkins, W.N. (1986). Tryptophan-trazodone treatment of aggressive behavior. Lancet, 19(11), 859–860.

    Google Scholar 

  • Oxenstierna, G., Edman, G., Iselius, L., Oreland, L., Ross, S.B., & Sedvall, G. (1986). Concentrations of monoamine metabolites in the cerebrospinal fluid of twins and unrelated individuals: a genetic study. Journal of Psychiatry Research, 20: 19–29.

    Google Scholar 

  • Pinner, E., & Rich, C. (1988). Effects of trazodone on aggressive behavior in seven patients with organic mental disorders. American Journal of Psychiatry, 145, 1295–1296.

    PubMed  Google Scholar 

  • Potter, W., & Manji, H. (1993). Are monoamine metabolites in cerebrospinal fluid worth measuring? Archives of General Psychiatry, 50, 653–656.

    PubMed  Google Scholar 

  • Pranzatelli, M.R. (1994). Serotonin and human myoclonus. Archive of Neurology, 51:605–617.

    Google Scholar 

  • Raine, A, Brennan, P., & Mednick, S.A. (1994). Birth complications combined with early maternal rejection at age 1 year predispose to violent crime at age 18 years. Archives of General Psychiatry, 51:984–988.

    PubMed  Google Scholar 

  • Raine, A., Brennan, P, Mednick, B., & Mednick, S. (1996). High rates of violence, crime, academic problems, and behavioral problems in males with both early neuromotor deficits and unstable family environments. Archives of General Psychiatry, 53:544–549.

    PubMed  Google Scholar 

  • Raleigh, M.J., Brammer, G.L., & McGuire, M.T. (1983). Male dominance, serotonergic systems, and the behavioral and physiological effects of drugs in vervet monkeys (cercopithecus aethiops sabaeus) in Ethopharmacology: Primate models of neuropsychiatric disorders. K. Miczek (Ed.). Alan R. Liss, Inc. New York.

    Google Scholar 

  • Raleigh, M.F., McGuire, M.T., Brammer, G.L., & Yuwiler, A. (1984). Social and environmental influences on blood serotonin concentrations in monkeys. Archives of General Psychiatry, 41:405–410.

    PubMed  Google Scholar 

  • Raleigh, M.J., Brammer, G.L., McGuire, M.T., & Yuwiler, A. (1985). Dominant social status facilitates the behavioral effects of serotonergic agonists. Brain Research, 348:274–83.

    PubMed  Google Scholar 

  • Raleigh, M.J., McGuire, M.T., Brammer, G.L., Pollack, D.B. & Yuwiler, A. (1991). Serotonergic mechanisms promote dominance acquisition in adult male vervet monkey. Brain Research, 559, 181–190.

    PubMed  Google Scholar 

  • Rao, U., Carson, G.A., Rappaport, M.D. (1991). Serum cholesterol and aggressive behavior in psychiatrically hospitalized children. Acta Psychiatr Scand, 83:77–78.

    PubMed  Google Scholar 

  • Ratey, J.J., Morill, R., & Oxenkrug, G. (1983). Use of propranolol for provoked and unprovoked episodes of rage. American Journal of Psychiatry, 140(10), 1356–1357.

    PubMed  Google Scholar 

  • Ratey, J.J., Sovner, R., Mikkelson, E., & Chmielinski, H.E. (1989). Buspirone therapy for maladaptive behavior and anxiety in developmentally disabled persons. Journal of Clinical Psychiatry, 50, 382–384.

    PubMed  Google Scholar 

  • Ratey, J.J., Sorgi, P., O’Driscoll, G.A., Sands, S., Daehler, M. L., Fletcher, J.R., Kadish, W., Spruiell, G., Polakoff, S., Lindem, K.J., Bemporad, J.R., Richardson, L., & Rosenfeld, B. (1992). Nadolol to treat aggression and psychiatric symptomatology in chronic psychiatric inpatients: A double-blind, placebo-controlled study. Journal of Clinical Psychiatry, 53(2), 41–46.

    PubMed  Google Scholar 

  • Realmuto, G.M., August, G.J., & Garfinkel, B.D. (1989). Clinical effect of buspirone in autistic children. Journal of Clinical Psychopharmacology, 9, 122–125.

    PubMed  Google Scholar 

  • Riddle, M.A., Anderson, G.M., Mcintosh, S., Harcherik, D.F., Shaywitz, B.A., & Cohen, D.J. (1986). Cerebrospinal fluid monoamine precursor and metabolite levels in children treated for leukemia: age and sex effects and individual variability. Biological Psychiatry, 21:69–83.

    PubMed  Google Scholar 

  • Ringo, D.L., Lindley, S.E., Faull, K.F., & Faustman, W.O. (1994). Cholesterol and serotonin: seeking a possible link between blood cholesterol and CSF 5-HIAA. Biological Psychiatry, 35:957–9.

    PubMed  Google Scholar 

  • Rosenberg, D.R., Johnson, K., & Sahl, R. (1992). Evolving mania in an adolescent treated with low-dose fluoxetine. Journal of Child and Adolescent Psychopharmacology, 2, 299–306.

    PubMed  Google Scholar 

  • Rosenthal, N.E., Sack, D. A., Wehr, T.A. (1983). In T.A. Wehr & F.K. Goodwin (Eds.), Circadian Rhythms and Affective Disorders (pp. 185–201). Boxwood Press, Pacific Grove, CA

    Google Scholar 

  • Roy, A., DeJong, J., & Linnoila, M. (1989). Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients. Archives of General Psychiatry, 46:609–612.

    PubMed  Google Scholar 

  • Roy, A., Adinoff, B., DeJong, J., & Linnoila, M. (1991). Cerebrospinal fluid variables among alcoholics lack seasonal variation. Acta Psychiatr Scand, 84, 579–582.

    PubMed  Google Scholar 

  • Roy, A. (1993). Serotonin, suicide and schizophrenia (letter). Canadian Journal of Psychiatry, 38(5): 369.

    Google Scholar 

  • Salomon, R.M., Mazure, C.M., Delgado, P.L., Mendia, P., Charney, D.S. (1994). Serotonin function in aggression: the effect of acute plasma tryptophan depletion in aggressive patients. Biological Psychiatry 35:570–2.

    PubMed  Google Scholar 

  • Seifert, W.E., Foxx, J.F., Butler, I.J. (1980). Age effect on dopamine and serotonin metabolite levels in cerebrospinal fluid. Annals of Neurology, 8:38–42.

    PubMed  Google Scholar 

  • Seilkowitz, M., Sunman, J., Pendergast, A., et at. (1990). Fenfluramine in prader-willi syndrome: A double-blind, placebo controlled trial. Archives of Disease of Childhood, 65, 112–114.

    Google Scholar 

  • Shaywitz, B.A., Cohen, D.J., & Bowers, M.B., Jr. (1977). CSF monoamine metabolites in children with minimal brain dysfunction. Evidence for alteration of brain dopamine. A preliminary report. Journal of Pediatrics, 90,76–71.

    Google Scholar 

  • Shetty, T., & Chase, T.N. (1976). Central monoamines and hyperkinase of childhood. Neurology, 26, 1000–1002.

    PubMed  Google Scholar 

  • Smith, S.E., Pihl, R.O., Young, S. W., & Ervin, F.R. (1985). Psychopharmacology, 87:173–177.

    PubMed  Google Scholar 

  • Stanley, M., Traskman-Bendz, L., & Dorovini-Zis, K. (1985). Correlations between aminergic metabolites simultaneously obtained from human CSF and brain. Life Science, 37, 1279–1286.

    Google Scholar 

  • Stein, D.J., Hollander, E., & Liebowitz, M. R. (1993). Neurobiology of impulsivity and the impulse control disorders. Journal of Neuropsychiatry and Clinical Neurosciences, 5:9–17.

    Google Scholar 

  • Stewart, A.M., Stewart, S.G. (1981). Serum cholesterol in antisocial personality: failure to replicate earlier findings. Neuropsychobiology, 7:9–11.

    PubMed  Google Scholar 

  • Stoff, D.M., Pasatiempo, A.P., Yeung, J., Cooper, T.B., Bridger, W.H., & Rabinovich, H. (1992). Neuroendocrine responses to challenge with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents. Psychiatry Research, 43(3), 263–276.

    PubMed  Google Scholar 

  • Swade, C., & Coppen, A. (1980). Seasonal variations in biochemical factors related to depressive illness. Journal of Affective Disorders, 2, 249–255.

    PubMed  Google Scholar 

  • Swedo, S.E., Kruesi, M.J.P., Leonard, H.L., Hamburger, S.D., Cheslow, D.L., Stipetic, M., & Potter, W.Z. (1989). Lack of seasonal variation in pediatric lumbar cerebrospinal fluid neurotransmitter metabolite concentrations. Acta Psychiatr Scand, 80:644–649.

    PubMed  Google Scholar 

  • Tolan, P.H., & Guerra, N.G. (1994). What works in reducing adolescent violence: An empirical review of the field. Monograph prepared for the Center for the Study and Prevention of Youth Violence. Boulder, CO: University of Colorado.

    Google Scholar 

  • Traskman L., Asberg, M., Bertilsson, L., & Sjostrand, L. (1981). Monoamine metabolites and suicidal behavior. Archives of General Psychiatry, 38: 631–636.

    PubMed  Google Scholar 

  • Virkkunen, M. (1979). Serum cholesterol in antisocial personality. Neuropsychobiology, 5:27–30.

    PubMed  Google Scholar 

  • Virkkunen, M. (1983). Serum cholesterol levels in homicidal offenders: Aloe cholesterol level is connected with a habitually violent tendency under the influence of alcohol. Neuropsychobiology, 10:65–69.

    PubMed  Google Scholar 

  • Virkkunen, M., & Penttinen, H. (1984). Serum cholesterol in aggressive conduct disorder: A preliminary study. Biological Psychiatry, 19:435–439.

    PubMed  Google Scholar 

  • Virkkunen, M., Eggert, M., Rawlings, R., & Linnoila, M. (1989). A prospective follow-up study of alcoholic violent offenders and fire setters. Archives of General Psychiatry, 53(6):523–529.

    Google Scholar 

  • Virkkunen, M., Goldman, D., Nielsen, D.A., & Linnoila, M. (1995). Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence. Journal of Psychiatry and Neuroscience, 20(4):271–5.

    PubMed Central  PubMed  Google Scholar 

  • Virkkunen, M., Eggert, M., Rawlings, R., & Linnoila, M. (1996). A prospective follow-up study of alcoholic violent offenders and fire setters. Archives of General Psychiatry, 53:523–529.

    PubMed  Google Scholar 

  • Volavka, J., Crowner, M., Brizer, D., Convit, A., et al. (1990). Tryptophan treatment of aggressive psychiatric inpatients. Biological Psychiatry, 28:728–32.

    PubMed  Google Scholar 

  • Wirz-Justice, A., Lichsteiner, M., & Feer, H. (1977). Diurnal and seasonal variations in human platelet serotonin in man. Journal of Neural Transmission, 41:7–15.

    PubMed  Google Scholar 

  • Yeh, S., Fricke, R.A., & Edwards, D.H. (1996). The effect of social experience on serotonergic modulation of the escape circuit of crayfish. Science, 271:366–69.

    PubMed  Google Scholar 

  • Yodyinyuad, U., DeLaRiva, D. H., Herbert, J., & Keverne, E.B. (1985). Relationship between dominance hierarchy, cerebrospinal fluid levels of amine transmitter metabolites (5-hydroxyindoleacetic acid and homovanillic acid) and plasma cortisol in monkeys. Neuroscience, 16:851–8.

    Google Scholar 

  • Young, S.N., Smith, S.E., Pihl, R., & Ervin, F.R. (1985). Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology, 87:173–177.

    PubMed  Google Scholar 

  • Yudofsky, S., Williams, D., & Gorman, J. (1981). Propranolol in the treatment of rage and violent behavior in patients with chronic brain syndromes. American Journal of Psychiatry, 138:218–220.

    PubMed  Google Scholar 

  • Zhang, B., & Harris-Warrick, R.M. (1994). Multiple receptors mediate the modulatory effects of serotonergic neurons in a small neural network. Journal Exp Biology, 190:55–77.

    Google Scholar 

  • Zubieta, J., & Alessi, N. (1992). Acute and chronic administration of trazodone in the treatment of disruptive behavior disorders in children. Journal of Clinical Psychopharmacology, 12:346–351.

    PubMed  Google Scholar 

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  1. Institute for Juvenile Research Department of Psychiatry, University of Illinois-Chicago, 907 South Wolcott Avenue, Chicago, Illinois, 60612, USA

    Markus J. P. Kruesi & Teresa Jacobsen

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  1. Markus J. P. Kruesi
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  1. University of Southern California, Los Angeles, California, USA

    Adrian Raine  & Sarnoff A. Mednick  & 

  2. Emory University, Atlanta, Georgia, USA

    Patricia A. Brennan

  3. Cambridge University, Cambridge, UK

    David P. Farrington

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Kruesi, M.J.P., Jacobsen, T. (1997). Serotonin and Human Violence. In: Raine, A., Brennan, P.A., Farrington, D.P., Mednick, S.A. (eds) Biosocial Bases of Violence. Nato ASI Series, vol 292. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4648-8_12

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