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Targeting Atherosclerotic Plaques

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Biomedical Aspects of Drug Targeting

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Abstract

Clinical imaging of atherosclerotic plaques is based on anatomical demonstration of the narrowing of the involved artery (1). Angioscopy (2) and intravascular ultrasound (3) can demonstrate the precise location of the lesions, the extent of luminal narrowing and plaque thickening. However, both methods are invasive and cannot provide the composition or the metabolic status of the atherosclerotic lesion (4). Plaques rich in macrophages and foam cells may denote high risk of plaque rapture (5) whereas fibrous plaques may denote slowly emergent lesions. Lesions rich in actively proliferating smooth muscle cells may be an indication of accelerated luminal diameter reduction (6). Other targets that might have potential applications may be associated with neoantigens that are expressed due to microvascular injury inherent in atherogenesis. Therefore, targeting macrophage, foam cell hyper-accumulation or hyperactivity intravascularly, neoexpression or hyperexpression of various vascular adhesion molecules, or the metabolites that may be incorporated into the cellular components of the atherosclerotic lesions may provide novel and specific diagnostic and therapeutic applications.

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Author information

Authors and Affiliations

  1. Bouve College of Health Sciences, School of Pharmacy, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, 02115, USA

    Ban-An Khaw PhD.

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  1. Ban-An Khaw PhD.
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Editors and Affiliations

  1. School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Vladimir Muzykantov M.D., Ph.D.

  2. School of Pharmacy, Northeastern University, Boston, MA, USA

    Vladimir Torchilin Ph.D., D.Sc.

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© 2002 Springer Science+Business Media New York

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Khaw, BA. (2002). Targeting Atherosclerotic Plaques. In: Muzykantov, V., Torchilin, V. (eds) Biomedical Aspects of Drug Targeting. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4627-3_4

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  • DOI: https://doi.org/10.1007/978-1-4757-4627-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-5312-4

  • Online ISBN: 978-1-4757-4627-3

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