Targeting the Pathological Myocardium

  • Ban-An Khaw


The rationale for targeting the pathological myocardium is to enable development of better diagnostic modalities or to enhance therapeutic interventions. Since the heart is an end-differentiated organ that has no substantial regenerative properties, any injury to the heart could potentially lead to high morbidity and mortality. The causes of myocardial injury are varied. Acute myocardial infarction results in oncotic myocardial cell death, whereas cardiomyopathies are now believed to be associated primarily with apoptotic myocardial cell death. If these myocardial disorders can be targeted specifically for early diagnosis, then morbidity and mortality may be reduced and novel therapeutic interventions may result in decreasing the injury to the heart. This chapter will focus primarily on targeting the oncotic myocardium. Targeting the apoptotic myocardium will not be considered in detail, but an introduction to the latest advances will be provided.


Acute Myocardial Infarction Right Ventricular Leave Anterior Oblique Cell Membrane Disruption Antimyosin Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Ban-An Khaw
    • 1
  1. 1.Bouve College of Health Sciences, School of Pharmacy, Department of Pharmaceutical SciencesNortheastern UniversityBostonUSA

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