Anti-HIV Immunotoxins

  • Seth H. Pincus
  • Hua Fang
  • Royce Wilkinson


The use of targeted therapies to treat infectious diseases is a novel application that requires a persistent infection that cannot be cleared by other means and the expression of microbial antigens on the surface of productively-infected cells. Although some bacterial or parasitic infections may meet these criteria, chronic viral infections and microbe-induced neoplasia are the most likely targets. In this chapter we will discuss the use of immunotoxins to treat human immunodeficiency virus (HIV) infection. The results demonstrate the importance of targeting the appropriate molecules and utilizing the cell biology of the microorganism.


Human Immunodeficiency Virus Infected Cell Human Immunodeficiency Virus Infection Pokeweed Antiviral Protein Infected Macaque 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Seth H. Pincus
    • 1
    • 2
  • Hua Fang
    • 1
    • 2
  • Royce Wilkinson
    • 1
    • 2
  1. 1.Department of MicrobiologyMontana State UniversityBozemanUSA
  2. 2.Research Institute for Children, Children’s HospitalLSU Health Sciences CenterNew OrleansUSA

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