LDL-Receptor Mediated Drug Targeting to Malignant Tumors in the Brain

  • Ranajoy Sarkar
  • David S. Halpern
  • Steven K. Jacobs
  • D. Robert Lu
Chapter

Abstract

Malignant tumors are composed of abnormal cells that usually grow very aggressively. It is extremely difficult to treat many of these malignant tumors with conventional methods, including surgical resection, radiation therapy, chemotherapy and combinations of these modalities. To enhance the efficacy of tumor treatment with chemotherapy, targeted drug delivery resulting in high concentrations of therapeutic compounds in tumor cells and relatively low concentrations in neighboring normal cells has been attractive and many approaches for drug targeting have been extensively evaluated.

Keywords

Cholesteryl Ester Target Drug Delivery Boron Neutron Capture Therapy Intermediate Density Lipoprotein Biomedical Aspect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Ranajoy Sarkar
    • 1
  • David S. Halpern
    • 2
  • Steven K. Jacobs
    • 3
  • D. Robert Lu
    • 1
  1. 1.College of PharmacyUniversity of GeorgiaAthensUSA
  2. 2.Isotron, Inc.AlpharettaUSA
  3. 3.New York Medical CollegeNew WindsorUSA

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