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Polymer-Drug Conjugates: Targeting Cancer

  • Ruth Duncan
Chapter

Abstract

Synthetic polymers are well known through their widespread use in biomedical materials, for example hip prostheses, contact lenses, vascular grafts and most recently as scaffolds for tissue engineering. Polymers are also routinely used as pharmaceutical excipients. Both these applications are far removed from the concept of “disease targeting.” However, the last decade has seen the emergence of several novel classes of therapeutic that exploit the properties of natural or synthetic water soluble polymers to provide opportunities for improved chemotherapy. They include biologically active polymeric drugs, polymer-drug conjugates, block copolymer micelles, polymer-protein conjugates and polymer-based non-viral vectors are currently being designed for gene delivery.

Keywords

Acute Myeloid Leukemia Maximum Tolerate Dose Passive Target Polymer Conjugate Block Copolymer Micelle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Ruth Duncan
    • 1
  1. 1.Centre for Polymer Therapeutics, Welsh School of PharmacyCardiff UniversityCardiffUK

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