Abstract
Cyclic AMP (cAMP) serves a central role in controlling the catabolic activity of both prokaryotic and eukaryotic cells. In bacteria the effects of cAMP are mediated by the cAMP receptor protein (CRP or CAP). Our aim in this article is to address the question: How does CRP activate transcription in bacterial cells? A detailed examination of the mode of action of CRP should help us understand better the mechanisms which govern the activation of genes in prokaryotes, and may also provide a conceptual framework in discussions on the role of activators of transcription in eukaryotes (e.g., enhancing sequences, steroid hormones).
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De Crombrugghe, B., Busby, S., Buc, H. (1984). Activation of Transcription by the Cyclic AMP Receptor Protein. In: Goldberger, R.F., Yamamoto, K.R. (eds) Biological Regulation and Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4619-8_4
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