Abstract
In a dynamic environment the key to survival is adaptation. Of the adaptive responses an organism generates in response to its changing environment, many are generated via the endocrine system. Hormones, the messengers of the endocrine system, have access to most cells, but their effect on any specific site will be modified by local factors. The hormones react with their target cells via specific hormone receptors either at the cell surface or intracellularly and the receptor-hormone complex then generates a signal that regulates cellular metabolism. Among many possible local factors that influence hormonal action, two important sites of regulation are alterations in the reaction of the hormone with the hormone receptor and transmission of the signal of complex formation.
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References
Aguilera, G., Shirar, A., Baukal, A., and Catt, K. J., 1979, Regulation of angiotensin II receptors in the adrenal glomerulosa in the rat, 61st Annual Meeting of the Endocrine Society, (Anaheim), Abstract No. 824, p. 278.
Almira, E. C., and Reddy, W. J., 1979, Effect of fasting on insulin binding to hepatocytes and liver plasma membranes from rats, Endocrinology 104: 205.
Aloj, S. M., Lee, G., Grollman, E. F., Beguinot, F., Consiglio, E., and Kohn, L. D., 1978, Role of phospholipids in the structure and function of the thyrotropin receptor, J. Biol. Chem. 954:9040.
Amatruda, J. M., Livingston, J. N., and Lockwood, D. H., 1975, Insulin receptor: Role in resistance of human obesity to insulin, Science 188: 264.
Aragona, C., and Friesen, H. U~., 1975, Specific prolactin binding site in the prostate and testis of rats, Endocrinology 97: 677.
Aragona, C., Bohnet, H., and Friesen, H.G., 1976a, Prolactin binding sites in the male rat liver following castration, Endocrinology 99: 1017.
Aragona, C., Bohnet, G. C., Fang, V. S., and Friesen, H. G., 1976b, Induction of lactogenic receptors II. Studies on the liver of hypophysectomized male rats and on rats bearing a growth hormone secretary tumor, Endocrinol. Res. Commun. 3: 199.
Archer, J. A., Gorden, P., Gavin, J. R., III, Lesniak, M. A., and Roth, P., 1973, Insulin receptors in human circulating lymphocytes: Application to the study of insulin resistance in man, J. Clin. Edocrinol. Metab. 36: 627.
Archer, J. A., Gorden, P., and Roth, J., 1975, Defect in insulin binding to receptors in obese man: Amelioration with calorie restriction, J. Clin. Invest. 55: 166.
Atlas, D., and Levitzki, A., 1978, Tentative identification of ß-adrenergic subunits, Nature 272: 370.
Baker, J. B., Simmer, R. L., Glenn, K. C., and Cunningham, D. D., 1979, Thrombin and epidermal growth factor become linked to cell surface receptors during mitogenic stimulation, Nature 278: 743.
Bar, R. S., Gorden, P., Roth, J., Kahn, C. R., and De Meyts, P., 1976, Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients. Effect of starvation, refeeding and dieting, J. Clin. Invest. 58: 1123.
Bar, R. S., Gorden, P., Roth, J., and Siebert, C. W., 1977, Insulin receptors in patients with insulinomas: Changes in receptor affinity and concentration, J. Clin. Endocrinol. Metab. 44: 1210.
Bar, R. S., Levis, W. R., Rechler, M. M., Harrison, L. C., Siebert, C., Podskalney, J., Roth, J., and Muggeo, M., 1978b, Extreme insulin resistance in ataxia telangiectasia, N. Engl. J. Med. 298: 1164.
Bar, R. S., Harrison, L. C., Muggeo, M., Gorden, P., Kahn, C. R., and Roth, J., 1979, Regulation of insulin receptors in normal and abnormal physiology in humans, Adv. Intern. Med. 34: 23.
Barden, N., and LaBrie, F., 1973, Receptor for thyrotropin-releasing hormone in plasma membranes of bovine anterior pituitary gland: Role of lipids, J. Biol. Chem. 248: 7601.
Baxter, D., and Lazarus, N. R., 1975, The control of insulin receptors in the New Zealand obese mouse, Diabetologia 11: 261.
Bergeron, J. J. M., Posner, B. I., Josefsberg, Z., and Sikstrom, R., 1978, Intracellular polypeptide hormone receptors. The demonstration of specific binding sites for insulin and human growth hormone in Golgi fractions isolated from the liver of female rats, J. Biol. Chem. 253: 4058.
Bilezikian, J. P., Loeb, J. N., and Gammon, P. E., 1979, The influence of hyperthyroidism and hypothyroidism on the ß-adrenergic responsiveness of the turkey erythrocyte, J. Clin. Invest. 63: 184.
Blackard, W. G., Guzelian, P. S., and Small, M. E., 1978, Down regulation of insulin receptors in primary cultures of rat hepatocytes in monolayer, Edocrinology 103: 548.
Blazquez, M. G., Rubalcava, B., Montesano, R., Orci, L., and Ungar, R. H., 1976, Development of insulin and glucagon binding and adenylate cyclase response in liver membranes of the prenatal, postnatal and adult rat: Evidence of glucagon resistance. Endocrinology 98: 1014.
Bohnet, H. G., Aragona, C., and Friesen, H. G., 1976, Induction of lactogenic receptors I. In the liver of hypophysectomized rats, Endocrinol. Res. Commun. 3: 187.
Bradley, C. J., Campbell, G. A., Marshall, S., Meites, J., and Collings, W., 1975, Alterations in prolactin binding activity of tissue slices in response to estrogen, Fed. Proc. 34: 343.
Broer, Y., Freychet, P., and Rosselin, G., 1977, Insulin and glucagon receptor interaction in the genetically obese Zucker rat: Studies of hormone binding and glucagon stimulated cyclic AMP levels in isolated hepatocytes, Endocrinology 101: 236.
Carpentier, J.-L., Gorden, P., Amherdt, M., Van Obberghan, E., Kahn, C. R., and Orci, L., 1978, 15I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative elctron microscope autoradiography, J. Clin. Invest. 61 (4): 1056.
Carpentier, J.-L., Lesniak, M., Barazone, P., Van Obberghan, E., Gorden, P., and Orci, L., 1979, Direct demonstration of binding and internalization of t25í-hGH in cultured human lymphocytes: A mechanism linking degradation of the hormone with the down regulation of the receptor, 61st Annual Meeting of the Endocrine Society (Anaheim), Abstract No. 30, p. 80.
Catt, K. J., 1976, Membrane Receptors for peptide hormones, Acta Endocrinol. 82: 3.
Catt, K. J., and Dufau, M. L., 1973, Spare gonadotropin receptors in rat testis, Nature New Biol. 244: 219.
Catt, K. J., and Dufau, M. L., 1978, Gonadotropin Receptors and regulation of interstitial cell function in the testis, in: Receptors and Hormone Action, Vol. III ( L. Birnbaumer and B. W. O’Malley, eds.), pp. 291–339, Academic Press, New York.
Chang, T. H., and Polakis, S. E., 1978, Differentiation of 3T3 L-1 fibroblasts to adipocytes. Effect of insulin and indomethacin on the level of hormone receptors, J. Biol. Chem. 253: 4693.
Chen, Y.-D. I., and Payne, A. H., 1977, Regulation of testicular LH receptors by homologous hormone; in vitro studies on receptor occupancy and receptor loss, Biochem. Biophys. Res. Commun. 74: 1589.
Chen, Y.-D. I., Shaw, M. J., and Payne, A. H., 1977, Steroid and FSH action on LH receptors and LHsensitive testicular responsiveness during sexual maturation of the rat, Mol. Cell. Endocrinol. 8: 291.
Cigorraga, S. B., Dufau, M. L., and Catt, K. J., 1978, Regulation of luteinizing hormone receptors and steroidogenesis in gonadotropin desensitized Leydig cells, J. Biol. Chem. 253: 4297.
Coleman, D. L., 1977, Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice, Diabetologia 14: 141.
Conti, M., Harwood, J. P., Hsueh, J. W., Dufax, M. L., and Catt, K. H., 1976, Gonadotropin-induced loss of hormone receptors and desensitization of adenylate cyclase in the ovary, J. Biol. Chem. 251: 7729.
Conti, M., Harwood, J. P., Dufau, M. L., and Catt, K. L., 1977a, Effect of gonadotropins-induced receptor regulation on biological responses of isolated rat luteal cells, J. Biol. Chem. 252: 8869.
Conti, M., Harwood, J. P., Dufau, M. L., and Catt, K. J., 1977b, Regulation of luteinizing hormone receptors and adenylate cyclase activity by gonadotropin in the rat ovary, Mol. Pharmacol. 13: 1024.
Costlow, M. E., Buschow, R. A., and McGuire, W. L., 1975, Prolactin stimulation of prolactin receptors in rat liver, Life Sci. 17: 1457.
Cuatrecasas, P., 1972, Properties of the insulin receptor isolated from liver and fat cell membranes, J. Biol. Chem. 247: 1980.
Cuatrecasas, P., 1974, Membrane receptors, Ann. Rev. Biochem. 43: 169.
Dahms, W. T., 1975, Effect of insulin and cortisol on rat adipose tissue insulin receptors, Diabetes 24 (Suppl. 2): 394.
Davidson, M. B., and Kaplan, S. A., 1977, Increased insulin binding by hepatic plasma membranes from diabetic rats. Normalization by insulin therapy, J. Clin. Invest. 59: 22.
De Meyts, P., 1976, Cooperative properties of hormone receptors in cell membranes, J. Supramol. Struct. 442:1. De Meyts, P., and Roth, J., 1975, Cooperativity in ligand binding: A new graphic analysis, Biochem. Biophys. Res. Commun. 66: 1118.
De Meyts, P., Roth, J., Neville, D. M., Jr., Gavin, J. R., III, and Lesniak, M. A., 1973, Insulin interactions with its receptors: Experimental evidence for negative cooperativity, Biochem. Biophys. Res. Commun. 55: 154.
De Meyts, P., Bianco, A. R., and Roth, J., 1978, Site-site interactions among insulin receptors: Characterization of the negative cooperativity, J. Biol. Chem. 251: 1877.
De Meyts, P., Place, M. M., Waelbroesk, M. Schutter, A., and Brandenburg, D., 1979a, Receptor binding and negative cooperativity of covalent dimers of insulin, 61st Annual Meeting of the Endocrine Society (Anaheim), Abstract No. 180, p. 117.
De Meyts, P., Keefer, L. M. Piron, M. A., Guttner, H. G., Dianescu, C., Saunders, D., and Brandenberg, D., 1979b, Imparied negative cooperativity of the semisynthetic analogues human (B24-lev) and (B25-lev) insulin, Biochem. Biophys. Res. Commun. 100: 1225 1236.
Desbuquois, B., and Cuatrecasas, P., 1973, Insulin receptors, Annu. Rev. Med. 24: 233.
Dryer, R. L., Heysinger, J., and Brown, J. D., 1979, In vitro effect of substituted sulfonylureas on insulin binding by rat liver plasma membrane receptors, Diabetes 28: 431.
Eastman, R. C., Lesniak, M. A., Roth, J., De Meyts, P., and Gordon, P., 1979, Regulation of receptor by homologous hormone enhances the sensitivity and broadens scope of radioreeptor assay for human growth hormone, J. Clin. Endocrinol. Metab. 49: 262.
Edelman, G. M., 1976, Surface modulation in cell recognition and cell growth, Science 192: 218.
Edelstein, S. J., Beyer, W. B., Eldefrawi, A. T., and Eldefrawi, M. E., 1975, Molecular weight of the acetylcholine receptors of electric organs and the effect of Triton X-100, J. Biol. Chem. 250: 6101.
Eisen, H., Nasi, S., Georgopoulos, C. P., Arndt-Jovin, D., and Ostertag, W., 1977, Surface changes in differentiating Friend erythroleukemic cells in culture, Cell 10: 689.
El-Allawy, R. M. M., and Gliemann, J., 1972, Trypsin treatment of adipocytes: Effect on sensitivity to insulin, Biochem. Biophys. Acta 273: 97.
Eldefrawi, M. E., and Eldefrawi, A. T., 1977, Acetylcholine receptors, in: Receptors and Recognition, Vol. 4 ( P. Cuatrecasas and M. F. Creaves, eds). pp. 27–42, Chapman and Hall, London.
Engelhard, V. H., Glaser, M., and Storm, D. R., 1978, Effect of membrane phospholipid compositional changes on adenylate cyclase in LM cells, Biochemistry 17: 3191.
Epstein, M. and Racker, E., 1978, Reconstitution of carbamylcholine dependent sodium ion flux and desensitization of the acetylcholine receptor from Torpedo californica, J. Biol. Chem. 253: 6660.
Fambrough, D. M., and DeVreotes, P. N., 1978, Newly synthesized acetylcholine receptors are located in the Golgi apparatus, J. Cell. Biol. 76: 237.
Feinglos, M. N., and Lebovitz, H. E., 1978, Sulfonyl-ureas increase the number of insulin receptors, Nature 276: 184.
Flier, J. S., Kahn, C. R., Jarrett, D. B., and Roth, J., 1976, Characterization of the antibodies to the insulin receptor: Cause of insulin-resistance diabetes in man, J. Clan. Invest. 58: 1442.
Freychet, P., 1976, Interactions of polypeptide hormones with cell membrane specific receptors: Sutdies with insulin and glucagon, Diabetologia 12: 83.
Freychet, P., and Forgue, E., 1975, Insulin receptors in the heart muscle: Demonstration of specific binding sites and impairment of insulin binding in the plasma membrane of the obese hyperglycemic mouse, Diabetes 24: 715.
Freychet, P., Roth, J., and Neville, D. M., Jr., 1971, Monoiodoinsulin: Demonstration of its biological activity and binding to fat cells and liver membranes, Biochem. Biophys. Res. Commun. 43: 400.
Freychet, P., Laudat, M. H., Laudat, P., Rosselin, G., Kahn, C. R., Gorden, P., and Roth, J., 1972, Impairment of insulin binding to the fat cell plasma membrane in the obese hyperglycemic mouse, FEBS Lett. 25: 339.
Gammeltoft, S., and Gliemann, J., 1973, Binding and degradation of 125I-labelled insulin by isolated rat fat cells, Biochim. Biophys. Acta 320: 16.
Gammeltoft, S., Kristensen, L. O., and Sestaft, L., 1978, Insulin receptors in isolated rat hepatocytes. Reassessment of binding properties and observations on the inactivation of insulin at 37°, J. Biol. Chem. 253: 8406.
Gavin, J. R., III, Roth, J., Neville, D. M., Jr., De Meyts, P., and Buell, D. N., 1974, Insulin-dependent regulation of insulin receptor concentrations: A direct demonstration in cell culture, Proc. Natl. Acad. Sci. U.S.A. 71: 84.
Gelehrter, T. D., 1976, Enzyme induction, N. Engl. J. Med. 294:522, 589, 646.
Ginsberg, B. H., 1977, The insulin receptor: Properties and regulation, in: Biochemical Actions of the Hormones ( G. Litwak, ed.), pp. 313–349, Academic Press, New York.
Ginsberg, B. H., Kahn, C. R., Roth, J., and De Meyts, P., 1976, Insulin-induced dissociation of its receptor into subunits: Possible molecular concomitant of negative cooperativity, Biochem. Biophys. Res. Commun. 73:1068.
Ginsberg, B. H., Kahn, C. R., and Roth, J., 1977, The insulin receptor of the turkey erythrocyte: Similarity to mammalian insulin receptors, Endocrinol. 100: 82.
Ginsberg, B. H., Cohen, R. M., Kahn, C. R., and Roth, J., 1978, Properties and partial purification of the detergent solubilized insulin receptor. A demonstration of negative cooperativity in micellar solution, Biochim. Biophys. Acta 542:88.
Ginsberg, B. H., Brown, T., and Spector, A. A., 1979, Membrane lipid unsaturation alters the properties of the insulin receptor, Diabetes 30:773–780.
Ginsberg, B. H., Jabour, J., and Spector, A. A., 1982, Effect of alterations in membrane lipid unsaturation on the properties of the insulin receptor of Ehrlich ascites cells, Biochim. Biophys. Acta 690:15.
Glass, J., Nunez, M. T., Fischer, S., and Robinson, S. H., 1978, Transferrin receptors, iron transport and ferritin metabolism in Friend erythroleukemia cells, Biochim. Biophys. Acta 542: 154.
Gliemann, J., and Sonne, O., 1978, Binding and receptor-mediated degradation of insulin in adipocytes, J. Bzol. Chem. 253: 7857.
Gliemann, J., Gammeltoft, S., and Vinton, J., 1975, Time course of insulin-receptor binding and insulin-induced lipogenesis in isolated rat fat cells, J. Bzol. Chem. 250: 3368.
Gludicelli, Y., 1978, Thyroid-hormone modulation of the number of ß-adrenergic receptors in rat fat-cell membranes, Biochem. J. 176: 1007.
Goldfine, I. D., 1978, Insulin receptors and the site of action of insulin, Life Sci. 23: 2639.
Goldfine, I. D., Gardner, J. D., and Neville, D. M., Jr., 1972, Insulin action in isolated rat thymocytes. I. Binding of 125I-insulin and stimulation of a-aminoisobutyric acid transport, J. Biol. Chem. 247:6919.
Goldfine, I. D., Kahn, C. R., Neville, D. M., Jr., Roth, J., Garrison, M. M., and Bates, R. W., 1973, Decreased binding of insulin to its receptors in rats with hormone induced insulin resistance, Biochem. Biophys. Res. Commun. 53:852.
Goldfine, I. D., Vigneri, R., Cohen, D., and Pliam, N. B., 1977, Intracellular binding sites for insulin are immunologically distinct from those on the plasma membrane, Nature 269:698.
Gould, R. J., Ginsberg, B. H., and Spector, A. A., 1979, Reconstitution of the solubilized insulin receptor into phospholipid vesicles, Endocrin. Res. Commun. 6:279.
Gould, R. J., Ginsberg, B. H., and Spector, A. A., 1982, Lipid effects on the binding properties of a reconstituted insulin receptor. J. Bzol. Chem. 257:447.
Green, H., and Kehinde, 0., 1974, Sublines of mouse 3T3 cells that accumulate lipid, Cell 1:113.
Green, H., and Kehinde, 0., 1975, An established preadipose cell line and its differentiation in culture, II. Factors affecting adipose conversion, Cell 5:19.
Green, H., and Kehinde, 0., 1976, Spontaneous heritable changes leading to increase adipose conversion in 3T3 cells, Cell 7:105.
Grefrath, S. P., Smith, P. B., and Appel, S. H., 1978, Characterization of the ß-adrenergic receptor and adenylate cyclase is skeletal muscle plasma membranes, Arch. Biochem. Biophys. 188:328.
Grollman, E. F., Habig, W. H., Bequinot, F., Dryer, S., and Lee, G., 1978, Tetanus toxin interactions with the glycoprotein component of the TSH receptor: Lipid modulation of receptor expression, Fed. Proc. 37:1399.
Grunfeld, C., Baird, K., and Kahn, C. R., 1981, Maintenance of 3T3–L1 cells in culture media containing saturated fatty acids decreases insulin binding and insulin action. Biochem. Biophys. Res. Commun. 103:219.
Hammes, G. G., and Rodbell, M., 1976, Simple model for hormone-activated adenylate cyclase systems, Proc. Natl. Acad. Sci. U.S.A. 73:1189.
Haour, F., Sanchez, P., Cathiard, A. M., and Saez, J. M., 1978, Gonadotropin receptor regulation in hypophysectomized rat Leydig cells, Biochem. Biophys. Res. Commun. 81:547.
Harrison, L. C., Martin, F. I. R., and Melick, R. A., 1976, Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects, J. Clin. Invest. 58:1435.
Harwood, J. P., Conti, M., Conn, P. M., Dufau, M. L., and Catt, K. J., 1978, Receptor regulation and target cell responses: Studies in the ovarian luteal cell, Mol. Cell. Endocrinol. 11:121.
Harwood, J. P., Dufau, M. L., and Catt, K. L., 1979, Differing specificities in the desensitization of ovarian adenylate cyclase by epinephrine and human chorionic gonadotropin, Mol. Pharmacol. 15:439.
Heinemann, S., Merlie, J., and Lindstron, J., 1978, Modulation of acetylcholine receptor in rat diaphram by anti-receptor sera, Nature 274:65.
Helderman, J. H., and Strom, T. B., 1977, Emergence of insulin receptors upon alloimmune T cell in the rat, J. Clin. Invest. 59:338.
Helderman, J. H., and Strom, T. B., 1978, Specific insulin binding site on T and B lymphocytes as a marker of cell activation, Nature 274:62.
Herington, A. C., Phillips, L. S., and Daughaday, W. H., 1976a, Pituitary regulation of human growth hormone binding sites by rat liver membranes, Metabolism 25: 341.
Herington, A. C., Burger, H. G., and Veith, N. M., 1976b, Binding of human growth hormone to hepatic lactogenic binding sites: Regulation by oestrogens and androgens, J. Endocrinol. 70:473.
Horvat, A., Li, E., and Katsoyannis, P. G., 1975, Cellular binding sites for insulin in rat liver, Biochim. Biophys. Acta 382:609.
Hsueh, A. J. W., Dufau, M. L., and Catt, K. J., 1976, Regulation of leuteinizing hormone receptors in testicular intestitial cells by gonadotropin, Biochem. Biophys. Res. Commun. 72:1145.
Hsueh, A. J. W., Dufau, M. L., and Catt, K. J., 1977, Gonadotropin induced regulation of leuteinizing hormone receptors and desensitization of testicular 3’:5’-cyclic AMP and testosterone responses, Proc. Natl. Acad. Sci. U.S.A. 74:592.
Hunziker-Dunn, M., Bockaert, J., and Birnbaumer, L., 1978, Physiological aspects of appearance and desensitization of gonadotropin-sensitive adenylyl cyclase in ovarian tissues, and membranes of rabbits, rats and pigs. in: Receptors and Hormone Action, Vol. III (L. Birnbaumer and B. W. O’Malley, eds.), pp. 393433, Academic Press, New York.
Jacobs, S., and Cuatrecasas, P., 1976, The mobile receptor hypothesis and “cooperativity” of hormone binding. Application to insulin, Biochim. Biophys. Acta 433:482.
Jacobs, S., Schecter, Y., Bissell, K., and Cuatrecasas, P., 1977, Purification and properties of the insulin receptor from rat liver membranes, Biochem. Biophys. Res. Commun. 77:981.
Jacobs, S., Chang, K. J., and Cuatrecasas, P., 1978, Antibodies to purified insulin receptor have insulin-like activity, Science 200:1283.
Jarrett, L., and Smith, R. M., 1974, Electron microscopic demonstration of insulin receptors on adipocyte plasma membranes utilizing a ferritin-insulin conjugate, J. Biol. Chem. 249:7024.
Jarett, L., Schweitzer, J. B., and Smith, R. M., 1981, Insulin receptors: Differences in structural organization on adipocyte and liver plasma membranes, Science 210:1127.
Jarett, L., Kiechle, F. L., and Parker, J. C., 1982, Chemical mediator or mediators of insulin action: Response to insulin and mode of action, Fed. Proc. 41:2736.
Johnson, G. L., Boume, H. R., Gleason, M. K., Coffin, P., Insel, P. A., and Melmon, K. L., 1979, Isolation and characterization of S49 lymphoma cells deficient in ß-adrenergic receptors: Relation of receptor number to activation of adenylate cyclase, Mol. Pharmacol. 15:16.
Kaduce, T. L., Awad, A. B., Fonteneli, J., and Spector, A. A., 1977, Effect of fatty acid saturation on alphaaminoisobutyric acid transport in Ehlich ascites-cells, J. Biol. Chem. 252:6624.
Kahn, C. R., 1975, Membrane rceptors for polypeptide hormones, in: Methods in Membrane Biology, Vol. 3 ( E. D. Korn, ed.), pp. 81–146, Plenum Publishing, New York.
Kahn, C. R., 1976, Membrane receptors for hormones and neurotransmitters, J. Cell Biol. 70: 261.
Kahn,C. R., 1978, Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinction, Metabolism 27:1893.
Kahn, C. R., and Roth, J., 1975, Cell membrane receptors for polypeptide hormones: Application to the study of disease states in mice and men, Am. J. Clin. Pathol. 63:656.
Kahn, C. R., Neville, D. M., Jr., Gorden, P., Freychet, P., and Roth, J., 1972, Insulin receptor defect in insulin resistance: Studies in the obese hyperglycemic mouse, Biochem. Biophys. Res. Commun. 48: 135.
Kahn, C. R., Neville, D. M., Jr., and Roth, J., 1973a, Insulin receptor interactions in the obese-hyperglycemic mouse, J. Biol. Chem. 248: 244.
Kahn, C. R., Goldfine, I. E., Neville, D. M., Jr., Roth, J., Garrison, M., and Bates, R., 1973b, Insulin receptor defect: A major factor in the insulin resistance of glucocorticoid excess, 55th Meeting of the Endocrine Society, Abstract No. 217 p. 168.
Kahn, C. R., Freychet, P., and Roth, J., 1974, Quantitative aspects of the insulin-receptor interaction in liver plasma membranes, J. Biol. Chem. 249:2249.
Kahn, C. R., Flier, J. S., Bar, R. S., Archer, J. A., Gorden, P., Martin, M., and Roth, J., 1976, The syndrome of insulin resistance and acanthosis nigricans. Insulin-receptor disorder in man, N. Engl. J. Med. 294: 739.
Kahn, C. R., Baird, K., Flier, J. S., and Jarrett, D. B., 1977, Effect of autoantibodies to the insulin receptor on isolated adipocytes. Studies of insulin binding and insulin action, J. Clin. Invest. 60: 1094.
Kahn, C. R., Baird, K. L., Jarrett, D. B., and Flier, J., 1978, Direct demonstration that receptor crosslinking or aggregation is important to insulin action, Proc. Natl. Acad. Sci. U.S.A. 75: 4209.
Kariman, K., and Lefkowitz, R. J., 1977, Decreased ß-adrenergic receptor binding in lymphocytes from patients with bronchial asthma, Am. Rev. Resp. Dis. 115:61.
Karlsson, F. A., Grunfield, C., Kahn, C. R., and Roth, J., 1978, Regulation of insulin receptors and insulin responsiveness in 3T3–L1 fatty fibroblasts, Endocrinology 104:1383.
Kasuga, M., Zick, Y., Blithe, D., Crettaz, M., and Kahn, C. R., 1982, Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system, Nature 298:667.
Kaumann, A. J., Birnbaumer, L., and Wittman, R., 1978, Heart ß-adrenoceptors, in: Receptors and Hormone Action, Vol. III ( L. Birnbaumer and B. W. O’Malley, eds.), pp. 133–177, Academic Press, New York.
Kelly, P. A., Posner, B. I., and Friesen, H. G., 1975, Effects of hypophysectomy, ovariectomy, and cyclohexi- mide treatment of specific binding sites for lactogenic hormones in rat liver, Endocrinology 97:1408.
Kempson, S., Marinetti, G. V., and Shaw, A., 1978, Hormone action at the membrane level. VII. Stimulation of dihydroalprenalol binding to ß-adrenergic receptors in isolated rat heart ventricle slices by triodothyronine and thyroxine, Biochim. Biophys. Acta 540:320.
Kern, P., Picard, J., Caron, M., and Veissiere, D., 1975, Decreased binding of insulin to liver plasma membrane receptors in hereditory diabetic mice, Biochim. Biophys. Acta 389:281.
Kobayashi, M., and Olefsky, J., 1978, Effect of experimental hyperinsulinemia on insulin binding and glucose transport in isolated rat adipocytes, Am. J. Physiol. 235:E53.
Kobayashi, M., Meek, J. C., and Streib, E., 1977, The insulin receptor in myotonic dystrophy, J. Clin. Endocrinol. Metab. 45:821.
Kohn, L. D., 1978, Relationships in the structure and function of receptors for glycoprotein hormones, bacterial toxins and interferon, in: Receptors and Recognition, Series A, Vol. 5 ( P. Cuatrecasas and M. F. Greaves, eds.), pp. 135–212, Chapman and Hall, London.
Kono, R., and Barham, F. W., 1971, The relationship between the insulin-binding capacity of fat cells and the cellular response to insulin. Studies with intact and typsin-treated fat cells, J. Biol. Chem. 246:6210.
Kosmakos, F. C., and Roth, J., 1978, Regulation of insulin and growth hormone receptors in vitro and in vivo, in: Protein Turnover and Lysozomal Function ( H. L. Segal and D. H. Doyle, eds.), pp. 763–777, Academic Press, New York.
Krauth, M. C., and Schillinger, E., 1977, Changes in insulin receptor concentration in rat fat cells following treatment with the gestagens clomegesterone acetate and cyproterone acetate, Acta Endocrinol. 86:667.
Krug, U., Krug, F., and Cuatrecasas, P., 1972, Emergence of insulin receptors on human lymphpocytes during in vitro transformation, Proc. Natl. Acad. Sci. U.S.A. 69:2604.
Kuri-Harcuch, W., and Green, H., 1977, Increasing activity of enzymes on pathway of triacylglycerol synthesis during adipose conversion of 3T3 cells, J. Biol. Chem. 252:2158.
Lamer, J., Cheng, K., Schwartz, C., Kikuchi, K., Tamura, S., Creacy, S., Dubler, R., Galasko, G., Pullin, C., and Katz, M., 1982, A proteolytic mechanism for the action of insulin via oligopeptide mediator formation, Fed. Proc. 41:2724.
Lamer, J., Cheng, K., Schwartz, C., Dubler, R., Creacy, S., Kikuchi, K., Tamura, S., Galasko, G., Pullin, C., and Katz, M., 1981, Chemical mechanism of insulin action via proteolytic formation of mediator peptides, Mol. Cell Biochem. 40:155.
Lee, T., Witzemann, M., Schimerlik, M., and Raftery, M. A., 1977, Cholinergic ligand-induced affinity changes in Torpedo californica acetylcholine receptor, Arch. Biochem. Biophys. 183:57.
Lee, G., Consiglio, E., Habig, W., Dyer, S., Hardegree, C., and Kohn, L. D., 1978, Structure-function studies of receptors for thyrotropin and tetanus toxin: Lipid modulation of effector binding to the glycoprotein receptor component, Biochem. Biophys. Res. Commun. 83:313.
Lefkowitz, R. J., 1976, ß-adrenergic receptors: Recognition and regulation, N. Engl. J. Med. 295: 323.
Lefkowitz, R. J., 1978, Regulation of 13-adrenergic receptors by ß adrenergic agonists, in: Receptors and Hormone Action, Vol. III ( L. Birnbaumer and B. W. O’Malley, eds.), pp. 179–194, Academic Press, New York.
Lesniak, M. A., and Roth, J., 1977, Regulation of receptor concentration by homologous hormones: Effect of human growth hormone on its receptor in IM-9 lymphocytes, J. Biol. Chem. 251: 3720.
Lesniak, M. A., and Roth, J., 1978, Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes, J. Biol. Chem. 251: 3720.
Levitski, A., Segel, L. A., and Steer, M. L., 1975, Co-operative response of oligomeric protein receptors coupled to non-co-operative ligand binding, J. Mol. Biol. 91:125.
Linsley, P. S., Blifeld, C., Wrann, M., and Fox, C. F., 1979, Direct linkage of epidermal growth factor to its receptor, Nature 278:745.
Livingston, J. N., Purvis; B. J., and Lockwood, D. H., 1978, Insulin-dependent regulation of insulin-sensitivity of adipocytes, Nature 273:394.
Luly, P., and Shinitsky, M., 1979, Gross structural changes in isolated liver cell plasma membranes upon binding of insulin, Biochemistry 18:445.
Mackall, J. C., Student, A. K., and Polakis, S. E., 1977, Induction of lipogenesis during differentiation in a “preadipocyte” cell line, J. Biol. Chem. 251:6462.
Maguire, M. E., Van Arsdale, P. M., and Gilman, A. G., 1976, An agonist-specific effect of guanine nucleotides on binding to beta adrenergic receptor, Mol. Pharmacol. 12:335.
Mahler, R. J., and Szabo, O., 1971, Amelioration of insulin resistance in obese mice, Am. J. Physiol. 221:980.
Malbon, C. C., Moreno, F. J., Cabelli, R. J., and Fain, J., 1978, Fat cell adenylate cyclase and ß-adrenergic receptors in altered thyroid states, J. Biol. Chem. 253:671.
Marinetti, G. V., Schlatz, L., and Reilly, K., 1972, Hormone-membrane interaction, in: Insulin Action (I. B. Fritz, ed.), pp. 207–276, Academic Press, New York.
Maturo, J. M., III, and Hollenberg, M. D., 1978, Insulin receptor: Interactions with nonreceptor glycoprotein from liver cell membranes, Proc. Natl. Acad. Sci. U.S.A. 75:3070.
Maxfield, F. R., Schlessinger, J., Shecter, Y., Pastan, I., and Willingham, M. C., 1978, Collection of insulin, EGF and a2-macroglobulin in the same patches of the surface of cultured fibroblasts and common internalization, Cell 14:805.
Meites, J., Lu, K. H., Wuttke, W., Welsch, C. W., Nagasawa, H., and Quadri, S. K., 1972, Recent studies on function and control of prolactin secretion in rats, Recent Prog. Horm. Res. 28:471.
Meldolisi, M. F., Fishman, P. H., Aloj, S. M., Ledley, F. D., Lee, G., Bradley, R. M., Brady, R. O., and Kohn, L. D., 1977, Separation of the glycoprotein and ganglioside components of thyrotropin receptor activity in plasma membranes, Biochem. Biophys. Res. Commun. 75:581.
Mickey, J. V., Tate, R., and Lefkowitz, R. J., 1975, Subsensitivity of adenylate cyclase and decrease ß adrenergic receptor binding after chronic exposure to (—)-isoproterenol in vitro, J. Biol. Chem. 250:5727.
Mickey, J. V., Tate, R., Millikan, D., and Lefkowitz, R. J., 1976, Regulation of adenylate cyclase-coupled ß adrenergic receptor binding sites by ß adrenergic catecholamines in vitro, Mol. Pharmacol. 12:409.
Muggeo, M., Bar, R. S., Roth, J., and Kahn, C. R., 1978, Two abnormalities in insulin binding to its receptor in the insulin resistance of acromegaly, Clin, Res. 26:310A.
Mukherjee, C., Caron, M. G., and Lefkowitz, R. J., 1975, Catecholamine-induced subsensitivity of adenylate cyclase associated with a loss of ß-adrenergic receptor binding sites, Proc. Natl. Acad. Sci. U.S.A. 72:1945.
Mukherjee, C., Caron, M. G., and Lefkowitz, R. J., 1976a, Regulation of adenylate cyclase coupled ß-adrenergic receptors by 0-adrenergic catecholamines, Endocrinology 99:347.
Mullin, B. R., Fishman, P. H., Lee, G., Aloj, S. M., Ledleg, F. D., Winand, R. J., Kohn, L. D., and Brady, R. O., 1976, Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors, Proc. Natl. Acad. Sci. U.S.A. 73:842.
O’Brian, R. D., and Gibson, R. E., 1974, Two binding sites in acetylcholine receptors of Torpedo marmorata electroplax, Arch Biochem. Biophys. 165:681.
O’Brian, R. D., Eldefrawi, M. E., and Eldefrawi, A. T., 1972, Isolation of acetylcholine receptors, Annu. Rev. Pharmacol. 12:19.
Olden, K., Pratt, R. M., Jaworski, C., and Yamada, K., 1979, Evidence for the role of carbohydrate in membrane transport: Specific inhibition by tunicamycin, Proc. Natl. Acad. Sci. U.S.A. 76:791.
Olefsky, J. M., 1975, Effect of dexamethasone on insuline binding, glucose transport and glucose oxidation of isolated rat adipocytes, J. Clin Invest. 56:1499.
Olefsky, J. M., and Kobayashi, M., 1978, Mechanism of the fasting-induced increase in insulin binding to rat adipocytes, J. Clin. Invest. 61:329.
Olefsky, J. M., and Reaven, G. M., 1974, Insulin binding in diabetes: Relationships with plasma insulin levels and insulin sensitivity, Diabetes 26:680.
Olefsky, J. M., Johnson, J., Liv, F., Jen, P., and Reaven, G. M., 1975, The effect of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes, Metabolism 24:517.
Olefsky, J. M., Bacon, V. C., and Baur, S., 1976, Insulin receptors of skeletal muscle: Specific insulin binding sites and demonstration of decreased number of sites in obese rats, Metabolism 25:175.
Olefsky, J. M., Marshall, S., Berhanu, P., Sackow, M., Heidenreich, K., and Green, A., 1982, Internalization and intracellular processing of insulin and insulin receptors in adipocytes, Metabolism 31:670.
Orci, L., Rufener, C., Malaisse-Lagae, F., Blondel, B., Amherdt, M., Bataille, D., Freychet, P., and Perrelet, A., 1975, A morphological approach to surface receptors in islet and liver cells, Isr. J. Med. Sci. 11:639.
Orkin, S. H., 1978, Differentiation of murine erythroleukemia Friend cells: An in vitro model of erythropoiesis, In Vitro 14:146.
Orly, J., and Schramm, M., 1976, Couping of catecholamine receptor from one cell with the adenylate cyclase from another cell by cell fusion, Proc. Natl. Acad. Sci. U.S.A. 73: 4110.
Oseid, S., Beck-Neilson, H., Pederson, O., and Sovik, O., 1977, Decreased binding of insulin to its receptor in patients with congenital generalized lipodystrophy, N. Engl. J. Med. 296: 245.
Papermaster, D. S., Converse, C. A., and Siu, J., 1975, Membrane biosynthesis in the frog retina: Opsin transport in the photo receptor cell, Biochemistry 14:1343.
Parry, G., 1978, Membrane assembly and turnover, Sub-cell. Biochem. 5: 261.
Pastan, I., Roth, J., and Macchia, V., 1966, Binding of hormone to tissue: The first step in polypeptide hormone action, Proc. Natl. Acad. Sci. U.S.A. 56: 1802.
Peterson, B., Bechner, S., and Blecher, M., 1978, Hormone receptors: 7. Characteristics of insulin receptors in a new line of cloned neonatal rat hepatocytes, Biochim. Biophys. Acta 542: 470.
Petrozelli, L. M., Ganguly, S., Smith, C. J., Cobb, M. H., Rubin, C. S., and Rosen, O. M., 1982, Insulin activates a tryosine-specific protein kinase in extracts of 3T3–L1 adipocytes and human placenta, Proc. Natl. Acad. Sci. U.S.A. 79: 6792.
Pilch, P. E., and Czech, M., 1980, Hormone binding alters the conformation of the insulin receptor, Science 210: 1152.
Pohl, S. L., Krans, M. J., Kozyreff, V., Birnbaumer, L., and Rodbell, M., 1971, The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. VI. Evidence for a role of membrane lipids, J. Biol. Chem. 246: 4447.
Pollet, R. J., Standaert, M. L., and Haase, B. A., 1977, Insulin binding to the human lymphocyte receptor. Evaluation of the negative cooperativity model, J. Biol. Chem. 252: 5828.
Posner, B. I., 1976a, Regulation of lactogen specific binding sites in rat liver: Studies on the role of lactogens and estrogen, Endocrinology 99: 1168.
Posner, B. I., 1976b, Characterization and modulation of growth hormone and prolactin binding in mouse liver, Endocrinology 98: 645.
Posner, B. I., Kelley, P. A. Shiu, R. P. C., and Friesen, H. G., 1974a, Studies of insulin, growth hormone andprolactin binding: Tissue distribution, species variation, and characterization, Endocrinology 95:521.
Posner, B. I., Kelley, P. A., and Friesen, H. G., 1975b, Induction of a lactogenic receptor in rat liver: Influence of estrogen and the pituitary, Proc. Natl. Acad. Sci. U.S.A. 71: 2407.
Posner, B. I., Kelley, P. A., and Friesen, H. G., 1974c, Induction of a lactogenic receptor in rat liver: Influence of estrogen and the pituitary, Proc. Natl. Acad. Sci. U.S.A. 71: 2407.
Posner, B. I., Josefsberg, Z., and Bergeron, J. J. M., 1978a, Intracellular polypeptide hormone receptor. Characterization of insulin binding sites in the Golgi fractions from the liver of female rats, J. Biol. Chem. 253: 4067.
Posner, B. I., Raquidan, D., Josefsberg, Z., and Bergeron, J. J., 1978b, Different regulation of insulin receptors in intracellular (Golgi) and plasma membranes from livers of obese and lean mice, Proc. Natl. Acad. Sci. U.S.A. 75: 3302.
Posner, B. I., Khan, M. N., and Bergeron, J. J., 1982, Endocytosis of peptide hormones and other ligands, Endocr. Rev. 3: 280.
Pratt, R. M., and Pastan, I., 1978, Decreased binding of epidermal growth factor to BALB/c 3T3 mutant cells defective in glycoprotein synthesis, Nature 272: 68.
Purvis, K., Torjesen, P. A., Haug, E., and Hansson, V., 1977, HCG suppression of LH receptors and responsiveness of testicular tissue to hCG, Mol. Cell. Endocrinol. 8: 73.
Reed, B. C., Kaufman, S. H., Mackall, J. C., Student, A. K., and Lane, M. D., 1977, Alterations in insulin binding accompanying differentiation of 3T3–L1 preadipocytes, Proc. Natl. Acad. Sci. U.S.A. 74: 4876.
Reed, B. C., Ronnett, G. V., and Lane, M. D., 1981, Role of glycosylation and protein synthesis in insulin receptor metabolism by 3T3–L1 mouse adipocytes, Proc. Natl. Acad. Sci. U.S.A. 78: 2908.
Reiness, C. G., Weinberg, C. B., and Hall, Z. W., 1978, Antibody to acetylcholine receptor increases degradation of junctional and extrajunctional receptors in adult muscle, Nature 274: 68.
Reuben, R. C., Khanna, P. L., Gazett, Y., Breslow, R., Rifkind, R. A., and Marks, P. A., 1978, Inducers of erythroleukemia differentiation. Relationship of structure to activity among planar-polar compounds, J. Biol. Chem. 253: 4214.
Richards, J. S., 1978, Hormonal regulation of ovarian hormone receptors, in: Receptors and Hormone Action, Vol. III ( L. Birnbaumer and B. W. O’Malley, eds.), pp. 479–491, Academic Press, New York.
Richards, J. S., and Midgley, A. R., Jr., 1976, Protein hormone action: A key to understanding ovarian follicular and luteal cell development, Biol. Reprod. 14: 82.
Rosen, O. M., Smith, C. J., Fung, C., and Rubin, C. S., 1978, Development of hormone receptors and hormone responsiveness in vitro. Effect of prolonged insulin treatment on hexose uptake in 3T3–L1 adipocytes, J. Biol. Chem. 253: 7559.
Rosen, O. M., Chia, G. H., Fung, C., and Rubin, C. S., 1979, Tunicamycin-mediated depletion of insulin receptors in 3T3–L1 adipocytes, J. Cell. Physiol. 99: 37.
Ross, E. M., and Gilman, A., 1980, Biochemical properties of hormone sensitive adenylate cyclase, Annu. Rev. Biochem. 49: 533.
Ross, M. J., Klymkowsky, M. W., Agard, D. A., and Stroud, R. M., 1977, Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica, J. Mol. Biol. 116: 635.
Roth, J., 1973, Peptide hormone binding to receptors: A review of direct studies in vitro, Metabolism 22:1059.
Ross, E. M., Howlett, A. C., Ferguson, K. M., and Gilman, A. G., 1978, Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme, J. Biol. Chem. 253: 6401.
Rubin, C. S., and Rosen, O. M., 1979, Development of insulin responsiveness in 3T3–L1 preadipocytes, Fed. Proc. 38: 306.
Rubin, C. S., Lai, E., and Rosen, O. M., 1977, Acquisition of increased hormone sensitivity during in vitro adipocyte development, J. Biol. Chem. 252: 3554.
Rubin, C. S., Hirsch, A., Fung, C., and Rosen, O. M., 1978, Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3–L1 cells, J. Biol. Chem. 253: 7570.
Saez, J. M., Haour, F., Loras, B., Sanchez, P., and Cathiard, A. M., 1978, Oestrogen induced Leydig cell refractoriness to gonadotrophin stimulation, Acta Endocrinol. 89: 379.
Scatchard, G., 1949, The attraction of protiens for small molecules and ions, Ann. N. Y. Acad. Sci. 51:660.
Schimke, R. T., 1975, Turnover of membrane proteins in animal cells, in: Methods in Membrane Research, Vol. 3 ( E. D. Korn, ed.), pp. 201–236, Plenum Publishing, New York.
Schlessinger, J., Shecter, Y., Willingham, M. C., and Pastan, I., 1978, Direct visualization of binding, aggregation and internalization of insulin and epidermal growth factor on living fibroblastic cells, Proc. Natl. Acad. Sci. U.S.A. 75: 2659.
Schlieper, P., and DeRobertis, E., 1977, Lipid bilayers and liposomes in reconstitution experiments with cholinergic proteolipid from Torpedo electroplax, Biochem. Biophys. Res. Commun. 75:886.
Seals, J. R., and Czech, M. P., 1982, Production by plasma membranes of a chemical mediator of insulin action, Fed. Proc. 41:2730.
Sharpe, R. M., 1976, hCG-induced decrease in availability of rat testis receptors, Nature 264:644.
Sharpe, R. M., 1977, Gonadotropin-induced reduction in the steroidogenic responsiveness of the immature rat testis, Biochem. Biophys. Res. Commun. 76: 957.
Shear, M., Insel, P. A., Melmon, K. L., and Coffino, P., 1976, Agonist-specific refractoriness induced by isoproteronol. Studies with mutant cells, J. Biol. Chem. 251: 7572.
Shecter, Y., Hernaez, L., and Cuatrecasas, P., 1978, Epidermal growth factor: Biological activity requires persistent occupation of high affinity cell surface receptors, Proc. Natl. Acad. Sci. U.S.A.75:5788.
Sherman, B. M., Stagner, J. I., and Zamudio, R., 1977, Regulation of lactogenic hormone binding in rat liver by steroid hormones, Endocrinology 100: 101.
Singer, S. J., and Nicolson, G. L., 1972, The fluid mosaic model of the structure of cell membranes, Science 175: 720.
Soll, A. H., 1976, Regulation of insulin receptor concentration by insulin: A possible mechanism for the insulin resistance of obesity, in: Biogenesis and Turnover of Membrane Molecules (J. S. Cook, ed.), pp. 179–205, Raven Press, New York.
Soll, A. H., Kahn, C. R., and Neville, D. M., Jr., 1975a, Insulin binding to liver plasma membranes in the obese hyperglycemic (ob/ob) mouse. Demonstration of a decreased number of functionally normal receptors, J. Biol. Chem. 250: 7402.
Soll, A. H., Kahn, C. R., Neville, D. M., Jr., and Roth, J., 1975b. Insulin receptor deficiency in genetic and acquired obesity, J. Clin. Invest. 56: 769.
Stauffacher, W. L., Orci, L., Cameron, D. P., Burr, I. M., and Renold, A. E., 1971, Spontaneous hyperglycemia and/or obesity in laboratory rodents: An example of possible usefulness of animal disease models with both genetic and environmental components, Recent Prog. Horm. Res. 27: 41.
Stephenson, R. P., 1956, A modification of receptor theory, Br. J. Pharmacol. 11: 379.
Strom, T. B., Bear, R. A., and Carpenter, C. B., 1975, Insulin-induced augmentation of lymphocyte-mediated cytotoxicity, Science 187: 1206.
Sutherland, E. W., and Rall, T. W., 1960, The relation of adenosine-3’,5’-phosphate and phosphorylase to the action of the catecholamines and other hormones, Pharmacol. Rev. 12: 265.
Tate, R. L., Holmes, J. M., Kohn, L. D., and Winand, R. A., 1975, Characteristics of a solubilized thyrotropin receptor from bovine thryoid plasma membranes, J. Biol. Chem. 250: 6527.
Tell, G. P., Haour, F., and Saez, J. M., 1978, Hormonal regulation of membrane receptors and cell responsiveness, Metabolism 27: 1566.
Terris, S., and Steiner, D. F., 1975, Binding and degradation of 125I-insulin by rat hepatocytes, J. Biol. Chem. 250: 8389.
Tevaarwerk, G. J. M., and Hudson, A. J., 1977, Carbohydrate metabolism and insulin resistance in myotonia dystrophica, J. Clin. Endocrinol. Metab. 44: 491.
Thomopoulous, P., Roth, J., and Lovelace, E., 1976, Insulin receptors in normal and transformed fibroblasts: relationship to growth and transformation, Cell 8: 417–423.
Thomopoulos, P., Barthellier, M., and Laudat, M. H., 1978, Loss of insulin receptors on maturation of reticulocytes, Biochem. Biophys. Res. Commun. 85: 1460.
Tornita, M., Furthmayr, H., and Marchesi, V. T., 1978, Primary structure of human erythrocyte glycophorin A. Isolation and characterization of peptides and complete amino acide sequence. Biochemistry, 17: 2964.
Tsuruhara, T., Dufau, M. L., Cigorraga, S., and Catt, K. J., 1977, Hormonal regulation of testicular luteinizing hormone receptors. Effects on cyclic AMP and testosterone responses in isolated Leydig cells, J. Biol. Chem. 252: 9002.
Verma, A. K., and Posner, B. I., 1979, Intracellular growth hormone receptors in pregnant mouse liver, 61st Annual meeting of the Endocrine Society (Anaheim), Abstract No. 31, p. 80.
Vigneri, R., Goldfine, I. D., Wong, K. Y., Smith, G. Y., and Pezzino, V., 1978, The nuclear envelope. The major site of insulin binding in rat liver nuclei, J. Biol. Chem. 253: 2098.
Watanabe, A. M., McConnaughey, M. M., Strawbridge, R. A., Fleming, J. W., Jones, L. R., and Besch, H. R., Jr., 1978, Muscarinic cholinergic receptor modulation of ß adrenergic receptor affinity for catecholamines, J. Biol. Chem. 253: 4833.
Waters, M. J., H. G. Friesen, and H. G. Bonnet, 1978, Regulation of prolactin receptors by steroid hormones and the use of radioligand assay in endocrine research, in: Receptors and Hormone Action, Vol. III ( L. Birnbaumer and B. W. O’Malley, eds.), pp. 457–477, Academic Press, New York.
Wessels, M. R., Mullikan, D., and Lefkowitz, R. J., 1978, Differences between agonist and antagonist binding following ß adrenergic receptor desensitization, J. Biol. Chem. 253: 3371.
Wieringa, T., and Krans, H. M. J., 1978, Reduced glucose transport and increased binding of insulin in adipocytes and from diabetic and fasted rats, Biochim. Biophys. Acta 538: 563.
Williams, L. T., Lefkowitz, R. J., Wathabe, A. M., Hathaway, D. R., and Besch, H. R., Jr., 1977, Thyroid hormone regulation of ß-adrenergic receptor number, J. Biol. Chem. 252: 2787.
Wright, D. P., Pont, A., and Tashjian, A. H., 1979, Biological active synthetic fragments of human calcitonin. 59th Annual Meeting of the Endocrine Society, Abstract No. 121, p. 69.
Yip, C. C., Yeung, C. W. T., and Moule, M. L., 1978, Photoaffinity labeling of insulin receptor of rat adipocyte membranes, J. Biol. Chem. 253: 1743.
Zatz, M., Kababian, J. W., and O’Dea, R. F., 1978, Regulation of ß adrenergic function in the rat pineal, in: Receptors and Hormone Action, Vol. III ( L. Birnbaumer and B. W. O’Malley, eds.), pp. 195–219, Academic Press, New York.
Zipf, W. B., Payne, A. H., and Kelch, R. P., 1978, Dissociation of lutropin-induced loss of testicular lutropin receptors and lutropin-induced desensitization of testosterone synthesis, Biochim. Biophys. Acta 540: 330.
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Ginsberg, B.H. (1984). Synthesis and Regulation of Receptors for Polypeptide Hormones. In: Goldberger, R.F., Yamamoto, K.R. (eds) Biological Regulation and Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4619-8_2
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