Synthesis and Regulation of Receptors for Polypeptide Hormones

  • Barry H. Ginsberg


In a dynamic environment the key to survival is adaptation. Of the adaptive responses an organism generates in response to its changing environment, many are generated via the endocrine system. Hormones, the messengers of the endocrine system, have access to most cells, but their effect on any specific site will be modified by local factors. The hormones react with their target cells via specific hormone receptors either at the cell surface or intracellularly and the receptor-hormone complex then generates a signal that regulates cellular metabolism. Among many possible local factors that influence hormonal action, two important sites of regulation are alterations in the reaction of the hormone with the hormone receptor and transmission of the signal of complex formation.


Insulin Receptor Adenylate Cyclase Receptor Occupancy Insulin Binding Receptor Concentration 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Barry H. Ginsberg
    • 1
  1. 1.Veterans Administration Medical Center; and Departments of Internal Medicine and Biochemistry, and Diabetes-Endocrinology Research CenterUniversity of IowaIowa CityUSA

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