Pulsatile Flow Through a Constricted Artery

  • V. O’Brien
  • L. W. Ehrlich


As part of our long standing interest in the etiology of atherosclerosis we are presently concentrating on an isolated moderate stenosis in a straight artery. The attack is three pronged, chronic in vivo experiments with healthy dogs, physical experiments in transparent models and approximate theoretical solutions. By studying the fluid dynamic field and the endothelial response we hope to establish the normal physiological state and thus be better able to define the disease mechanisms leading to deposition of atherosclerotic plaque.


Pulsatile Flow Recirculation Region Laser Doppler Velocimetry Moderate Stenosis Head Tank 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    D. F. Young and F. Y. Tsai, “Flow characteristics in models of arterial stenosis — I. Steady Flow and U. Unsteady Flow,” J. Biomech. 6, 395–410 (1973).CrossRefGoogle Scholar
  2. 2.
    M. D. Deshpande, D. P. Giddens, and R. F. Mabon, “Steady laminar flow through modelled vascular stenoses,” J. Biomech. 9, 165–174 (1976).CrossRefGoogle Scholar
  3. 3.
    V. O’Brien and L. W. Ehrlich, “Pulsatile flow through stenosed arteries,” ASME 1977 Biomechanics Symp. (ASME AMD Vol. 23, pp. 113–116 ).Google Scholar
  4. 4.
    J. S. Lee and Y. C. Fung, “Flow in locally constricted tubes at low Reynolds numbers,” J. Appl. Mech. 37, 916 (1970).Google Scholar
  5. 5.
    L. W. Ehrlich, “The numerical solution of a NavierStokes problem in a stenosed tube: a danger in boundary approximations of implicit marching schemes,” Comp. & F1. 7, 247–256 (1979).MathSciNetGoogle Scholar
  6. 6.
    D. J. Schneck and F. J. Walburn, “Unsteady laminar-flow separation in tubes — II. The effect of variations in the frequency and amplitude of flow oscillations,” Rpt. VPI-E-79–21, June 1979.Google Scholar
  7. 7.
    V. O’Brien, L. W. Ehrlich and M. H. Friedman, “Unsteady flow in a branch,” J. F1. Mech. 75, 315–336 (1976).zbMATHCrossRefGoogle Scholar
  8. 8.
    S. F. Grace, “Oscillatory motion of a viscous liquid in a long straight tube,” Phil. Mag. 5, 933–939 (1928).Google Scholar
  9. 9.
    J. C. Bentz and N. A. Evans, “Hemodynamic flow in the region of a simulated stenosis,” ASME paper 75-WA/Bio10, 1975 (also Bentz Ph.D. thesis, Univ. Penna., 1974 ).Google Scholar
  10. 10.
    F. B. Gessner, “Hemodynamic theories of atherogenesis,” Circ. Res. 33, 259–266 (1973).CrossRefGoogle Scholar
  11. 11.
    W. McMichael, “Interphase mass and heat transfer in pulsatile flow,” Ph.D. thesis, Rice Univ. (1973).Google Scholar
  12. 12.
    F. F. Mark, C. B. Bargeron, O. J. Deters, and M. H. Friedman, “Experimental investigations of steady and pulsatile laminar flow in a 90° branch,” Trans. ASME (JAM) 99E, 372–377 (1977); see also Proc. 28th ACEMB, 1975.Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • V. O’Brien
    • 1
  • L. W. Ehrlich
    • 1
  1. 1.Applied Physics LaboratoryJohns Hopkins UniversityLaurelUSA

Personalised recommendations