Lumped Parameter Modeling of the Increased Hydraulic Resistance in Hypertension

  • P. M. Hutchins
  • V. L. Roddick
  • J. W. Dusseau


Established hypertension is characterized by an elevated hydraulic resistance to blood flow through the organs of the body. The lack of understanding concerning the pathogenesis of essential hypertension may be due largely to the simplistic techniques utilized in analyzing vascular resistance. The inability to separate resistance into its constituent parts is of particular importance in this regard.


Hydraulic Resistance Structural Resistance Lump Parameter Modeling Poiseuille Equation Small Arteriole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ferrone, R.A., G.M. Walsh, M. Tsuchiya, and E.D. Frohlich: Comparison of Hemodynamics in Conscious Spontaneous and Renal Hypertensive Rats. Amer. J. Physiol. 236 (3): H403 – H408, 1979.Google Scholar
  2. 2.
    Brock, T.A. and J.N. Diana: Effect of DOCA-NaCl Hypertension on Pre-and Postcapillary Resistance in Isolated Hindlimbs of Dogs. Amer. J. Physiol. 236 (4): H586 – H591, 1979.Google Scholar
  3. 3.
    Romanovska, L., I. Pierovsky, and J. Stribrna: Blood Flow and Vascular Resistance in Lower Limbs in Hypertensives at Rest and at Reactive Hyperemia. Cor Vasa 19 (1): 61–65, 1977.Google Scholar
  4. 4.
    Cox, R.H.: Comparison of Arterial Wall Mechanics in Normotensive and Spontaneously Hypertensive Rats. Amer. J. Physiol. 237 (2): H159 – H167, 1979.Google Scholar
  5. 5.
    Berry, C.L. and S.E. Greenwald: Effects of Hypertension on the Static Mechanical Properties and Chemical Composition of the Rat Aorta. Cardiovas. Res. 10 (4): 437–451, 1976.CrossRefGoogle Scholar
  6. 6.
    Mulvany, M.J., P.K. Hansen, and C. Aalkjaer: Direct Evidence that the Greater Contractility of Resistance Vessels in Spontaneously Hypertensive Rats is Associated with a Narrowed Lumen, a Thickened Media, and an Increased Number of Smooth Muscle Cell Layers. Circ. Res. 43: 854–864, 1978.CrossRefGoogle Scholar
  7. 7.
    Furuyama, M.: Histometrical Investigations of Arteries in Reference to Arterial Hypertension. Tohoku J. Exp. Med. 76: 388–414, 1962.Google Scholar
  8. 8.
    Okamoto, K. and K. Aoki: Development of a Strain of Spontaneously Hypertensive Rats. Jap. Circ. J. 27: 282–293, 1963.CrossRefGoogle Scholar
  9. 9.
    Hutchins, P.M., A.W. Greene, and T.D. Rains: Effect of Isoproterenol on the Blood Vessels of the Spontaneously Hypertensive Rat. Microvas. Res. 9: 101–106, 1975.CrossRefGoogle Scholar
  10. 10.
    Baez, S. and L.R. Orkin: Microcirculatory Reactions to Chemical Denervation in the Anesthetized Rat. Bibl. Anat. 9: 61–65, 1967.Google Scholar
  11. 11.
    Hutchins, P.M. and A.E. Darnell: Observations of a Decreased Number of Small Arterioles in Spontaneously Hypertensive Rats. Circ. Res. 34–35 (Supp. I): 161–165, 1974.Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • P. M. Hutchins
    • 1
  • V. L. Roddick
    • 1
  • J. W. Dusseau
    • 1
  1. 1.Departments of Biomedical Engineering Physiology and PharmacologyBowman Gray School of MedicineWinston-SalemUSA

Personalised recommendations