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Biochemistry of Halogenated Nucleosides and Nucleotides

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Biochemistry of Halogenated Organic Compounds

Part of the book series: Biochemistry of the Elements ((BOTE,volume 9A+B))

Abstract

The classic biochemical studies of Peters and co-workers, demonstrating the biosynthesis of the extremely toxic fluorocitrate from fluoroacetate, provided the initial example of the profound biological consequences of lethal synthesis (Chapter 1). The syntheses of fluorinated steroids by Fried and co-workers, based in part on the precedent provided by the altered biological activity of fluorocitrate, was a second development of historical proportions (Chapter 3). Of comparable scientific impact was the synthesis of 5-fluorouracil (fl5ura), 5-fluoroorotic acid (fl5oro), and 5-fluorocytosine (fl5cyt) (Fig. 5-1) by Heidelberger et al. (1957).

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    Kenneth L. Kirk

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Kirk, K.L. (1991). Biochemistry of Halogenated Nucleosides and Nucleotides. In: Biochemistry of Halogenated Organic Compounds. Biochemistry of the Elements, vol 9A+B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4605-1_5

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