Halogenated Analogues of Products of the Arachidonic Acid Cascade: Prostaglandins, Thromboxanes, and Leukotrienes

  • Kenneth L. Kirk
Part of the Biochemistry of the Elements book series (BOTE, volume 9A+B)


The eicosanoids are a group of C-20 unsaturated acids that have important roles in the regulation of such physiological functions as fertility control and induction of labor, regulation of blood platelet aggregation, gastric acid secretion, stimulation of smooth muscle activity, and inflammation response. Since the initial isolation and identification of prostaglandins from sheep seminal vesicle glands and from human semen (PGF2α and PGE, respectively) in the 1950s by Bergström and Sjövall [Bergström et al., 1963; reviewed by von Euler and Eliasson (1963)], a diverse series of acids have been identified. These include the primary prostaglandins and prostacyclins, thromboxanes, and unsaturated eicosanoic acids having perhydroxyl and hydroxyl substitution (leukotrienes). These compounds, collectively named eicosanoids, are derived enzymatically from C-20 acids, most notably arachidonic acid, as shown in Fig. 4-1 (the “arachidonic acid cascade”). A recent review of the biosynthesis, nomenclature, and physiological role of eicosanoids is provided by Moore (1985).


Methyl Ester Arachidonic Acid Gastric Acid Secretion Arachidonic Acid Cascade Enol Ether 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Kenneth L. Kirk
    • 1
  1. 1.National Institutes of HealthBethesdaUSA

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