Collagen Pathology at the Molecular Level

  • Charles M. Lapière
  • Betty Nusgens


A new era of pathology has started with the development of molecular biology. Much progress has been made thanks to advancing knowledge of physiological pathways which are involved in the function of cells and tissues. Conversely, the contribution of pathology to the understanding of such pathways has proved most important. Literature provides a basis for initiating a classification of diseases at the molecular level, hopefully enabling one to track specific defects of the connective tissues from its clinical expression to the altered chemical reaction(s) which produce it.


Osteogenesis Imperfecta Prolyl Hydroxylase Lysyl Oxidase Collagenolytic Activity Urinary Hydroxyproline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Charles M. Lapière
    • 1
  • Betty Nusgens
    • 1
  1. 1.Service de Dermatologie, Hôpital de BavièreUniversité de LiègeLiègeBelgium

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