The genetic basis of resistance to antimicrobial drugs

  • T. J. Franklin
  • G. A. Snow

Abstract

The development of safe, effective antimicrobial drugs has revolutionized medicine in the past 60 years. Morbidity and mortality from microbial disease have been drastically reduced by modern chemotherapy. Unfortunately, micro-organisms are nothing if not versatile, and the brilliance of the chemotherapeutic achievement has been dimmed by the emergence of microbial strains presenting a formidable array of defences against our most valuable drugs. This should not surprise us, since the evolutionary history of living organisms is concerned with their adaptation to the environment. The adaptation of micro-organisms to the toxic hazards of antimicrobial drugs is therefore probably inevitable. The extraordinary speed with which antibiotic resistance has spread amongst bacteria during the era of chemotherapy has been due, in large measure, to the remarkable genetic flexibility of this group of organisms.

Keywords

Human Immunodeficiency Virus Gene Cassette Human Immunodeficiency Virus Protease Mosaic Gene Replicative Transposition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Further reading

  1. Alekshun, M. N. and Levy, S. B. (1997). Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon. Antimicrob. Agents Chemother. 41, 2067.PubMedGoogle Scholar
  2. Courvalin, P. (1994). Transfer of antibiotic resistant genes between Gram-positive and Gram-negative bacteria. Antimicrob. Agents Chemother. 38, 1447.PubMedCrossRefGoogle Scholar
  3. George, A. M., Hall, R. M. and Stokes, H. W. (1995). Multidrug resistance in Klebsiella pneumoniae: a novel-gene ramA confers a multidrug resistance phenotype in Escherichia coli. Microbiol. 141, 1909.Google Scholar
  4. Lanka, E. and Wilkins, B. M. (1995). DNA processing reactions in bacterial conjugation. Ann. Rev. Biochem. 64, 141.PubMedCrossRefGoogle Scholar
  5. Leigh Brown, A. J. and Richman, D. D. (1997). HIV-1: gambling on the evolution of drug resistance. Nature Medicine 3, 268.PubMedCrossRefGoogle Scholar
  6. Prescott, L. M., Harley, J. P. and Klein, D. A. (1996). Microbiology, 3rd edn, William C. Brown, Dubuque IA.Google Scholar
  7. Recchia, G. D. and Hall, R. M. (1995). Gene cassettes: a new class of mobile element. Microbiol. 141, 3015.CrossRefGoogle Scholar
  8. Salyers, A. A. and Amabile-Cuevas, C. F. (1997). Why are antibiotic resistance genes so resistant to elimination? Antimicrob. Agents. Chemother. 41, 2321.PubMedGoogle Scholar
  9. Salyers, A. A. et al. (1995). Conjugative transposons: an unusual and diverse set of integrated gene transfer elements. Microbiol. Rev. 59, 579.PubMedGoogle Scholar
  10. Tenover, F. C. and Hughes, J. M. (1996). The challenge of emerging infectious diseases: development and spread of multiply-resistant bacterial pathogens. Science 275, 300.Google Scholar
  11. Tomasz, A. and Munoz, R. (1995). 3-Lactam antibiotic resistance in Gram-positive bacterial pathogens of the upper respiratory tract: a brief overview of mechanisms. Microbiol. Drug Resist. 1, 103.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • T. J. Franklin
    • 1
  • G. A. Snow
    • 1
  1. 1.Zeneca PharmaceuticalsMacclesfield, CheshireUK

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