Abstract
The antimicrobial agents described so far have been arranged together according to their primary effects on cellular metabolism and biosynthesis. This approach accounts for many of the most important drugs in current antimicrobial therapy. There are, however, several valuable drugs whose various modes of action fall outside those most commonly encountered. In this chapter we describe some important examples of compounds with unusual actions which we have arranged according to their therapeutic targets: antibacterial, antifungal, antiviral and antiprotozoal.
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Chaudhuri, A. R. and Ludena, R. F. (1996). Griseofulvin: a novel interaction with brain tubulin. Biochem. Pharmacol. 51, 903.
Cohen, J. L. (1996). Protease inhibitors: a tale of two companies. Science 272, 1882.
Dachs, G. V., Abatt, V. R. and Woods, D. R. (1995). Mode of action of metronidazole and a Bacteroides fragilis metA resistance gene in Escherichia coll. J. Antimicrob. Chemother. 35, 483.
Egan, T. J., Ross, D. C. and Adams, P. A. (1994). Quinoline antimalarial drugs inhibit spontaneous formation of ß-haematin (malaria pigment). FEBS Letters 352, 54.
Fry, M. and Pudney, M. (1992). Site of action of the antimalarial hydroxynaphthoquinone, 2[trans-4-(4’-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naph-thoquinone (566C80). Biochem. Pharmacol. 43, 1545.
Jefford, C. W. (1997). Peroxidic antimalarials. Adv. Drug Res. 29, 271.
Pinto, L. H. (1995). Understanding the mechanism of the antiinfluenza drug amantadine. Trends Microbiol. 3, 271.
Sen, G. S. and Lengyell, P. (1992). The interferon system: a bird’s eye view of its biochemistry. J. Biol. Chem. 267, 5017.
Wang, C. C. (1995). Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis. Ann. Rev. Pharmacol. Toxicol. 35, 93.
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© 1998 Springer Science+Business Media Dordrecht
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Franklin, T.J., Snow, G.A. (1998). Antimicrobial drugs with other modes of action. In: Biochemistry and Molecular Biology of Antimicrobial Drug Action. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4599-3_6
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DOI: https://doi.org/10.1007/978-1-4757-4599-3_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-4601-3
Online ISBN: 978-1-4757-4599-3
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