Inhibitors of nucleic acid synthesis

  • T. J. Franklin
  • G. A. Snow


Many antimicrobial substances, both synthetic chemicals and natural products, inhibit the biosynthesis of nucleic acids. However, few of these inhibitors are clinically useful as antimicrobial drugs because most do not distinguish between nucleic acid synthesis in the infecting micro-organism and in the host. Many inhibitors of nucleic acid synthesis are therefore too toxic to the host for safe use as antimicrobial agents. However, there are important exceptions which are described in this chapter.


Human Immunodeficiency Virus Thymidine Kinase Nucleoside Analogue Double Helix Dihydrofolate Reductase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Further reading

  1. Gootz, T. D. and Brighty, K. E. (1996). Fluoroquinolone antibacterials: SAR, mechanism of action, resistance and clinical aspects. Medicin. Res. Rev. 16, 433.CrossRefGoogle Scholar
  2. Hitchings, G. H. (1983). Inhibition of folate metabolism in chemotherapy. Handb. Exp. Pharmacol. 64, 11.CrossRefGoogle Scholar
  3. Katz, R. A. and Skalka, A. M. (1994). The retroviral enzymes. Ann. Rev. Biochem. 63, 133.PubMedCrossRefGoogle Scholar
  4. Kumar, K. P. Reddy, P. S. and Chatterji, D. (1992). Proximity relationship between the active site of Escherichia coli RNA polymerase and rifampin binding domain: a resonance energy-transfer study. Biochemistry 31, 7519.PubMedCrossRefGoogle Scholar
  5. Lewis, R. J. et al. (1996). The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography. EMBO J. 15, 1412.PubMedGoogle Scholar
  6. Prescott, L. M., Harley, J. P. and Klein, D. A. (1996) Microbiology, 3rd edn, William C. Brown.Google Scholar
  7. Richman, D. D. (1994). Drug resistance in viruses. Trends Microbiol. 2, 401.PubMedCrossRefGoogle Scholar
  8. Wilson, W. D. and Jones, R. L. (1981). Intercalating drugs: DNA binding and molecular pharmacology. Adv. Pharmacol. Chemother. 18, 177.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • T. J. Franklin
    • 1
  • G. A. Snow
    • 1
  1. 1.Zeneca PharmaceuticalsMacclesfield, CheshireUK

Personalised recommendations