Inhibitors of nucleic acid synthesis

  • T. J. Franklin
  • G. A. Snow

Abstract

Many antimicrobial substances, both synthetic chemicals and natural products, inhibit the biosynthesis of nucleic acids. However, few of these inhibitors are clinically useful as antimicrobial drugs because most do not distinguish between nucleic acid synthesis in the infecting micro-organism and in the host. Many inhibitors of nucleic acid synthesis are therefore too toxic to the host for safe use as antimicrobial agents. However, there are important exceptions which are described in this chapter.

Keywords

Human Immunodeficiency Virus Thymidine Kinase Nucleoside Analogue Double Helix Dihydrofolate Reductase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Further reading

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Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • T. J. Franklin
    • 1
  • G. A. Snow
    • 1
  1. 1.Zeneca PharmaceuticalsMacclesfield, CheshireUK

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