Inhibitors of nucleic acid synthesis
Many antimicrobial substances, both synthetic chemicals and natural products, inhibit the biosynthesis of nucleic acids. However, few of these inhibitors are clinically useful as antimicrobial drugs because most do not distinguish between nucleic acid synthesis in the infecting micro-organism and in the host. Many inhibitors of nucleic acid synthesis are therefore too toxic to the host for safe use as antimicrobial agents. However, there are important exceptions which are described in this chapter.
KeywordsHuman Immunodeficiency Virus Thymidine Kinase Nucleoside Analogue Double Helix Dihydrofolate Reductase
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