Skip to main content
SpringerLink
Log in

Enzymes in Organic Solvents

  • Chapter
Book cover Biocatalysts for Industry

Part of the book series: Topics in Applied Chemistry ((TAPP))

Abstract

The high potential of biocatalysis for a variety of industrial applications is widely recognized. For centuries various enzyme-based transformations have been used in wine and bread making, milk clotting, and beer brewing. Added to this list are recent advances in food technology such as processes for the production of high-fructose corn syrup, chillproofing of beer, hydrolysis of lactose, and saccharification of starch-containing raw materials. The food industry is now the largest consumer of enzymes, accounting for over 50% of the $ 445 million enzyme market.1 The use of enzymes as practical catalysts in the chemical industry, however, has been limited. This is mainly attributed to their high cost, relative instability in harsh industrial environments, and strong competition with current and well established chemical processes. However, applied enzymology has always been an area of high expectation. Unique properties of enzymes such as their superior regio- and stereoselectivity, ability to catalyze a variety of reactions under mild conditions, nontoxicity, and biodegradability make them potentially useful in a variety of applications.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. C. G. Greenwald and J. M. Nystrom, Spectrum, Food Industry, Arthur D. Little Decision Resources (1988).

    Google Scholar 

  2. L. G. Butler, Enzyme Microb. Technol. 1, 253 (1979).

    Article  CAS  Google Scholar 

  3. S. Fukui and A. Tanaka, Adv. Biochem. Eng. 29, 1 (1984).

    CAS  Google Scholar 

  4. M. D. Lilly, J. Chem. Tech. Biotechnol. 32, 162 (1982).

    CAS  Google Scholar 

  5. G. Carrea, Trends Biotechnol. 2, 102 (1984).

    Article  CAS  Google Scholar 

  6. P. L. Luisi, Angew. Chem. 24, 439 (1985).

    Article  Google Scholar 

  7. P. L. Luisi and C. Laane, Trends Biotechnol. 4, 153 (1986).

    Article  CAS  Google Scholar 

  8. A. M. Klibanov, Chemtech. 16, 354 (1986).

    CAS  Google Scholar 

  9. J. S. Deetz and J. D. Rozzell, Trends Biotechnol. 6, 15 (1988).

    Article  CAS  Google Scholar 

  10. A. Zaks and A. J. Russell, J. Biotechnol. 8, 259 (1988).

    Article  CAS  Google Scholar 

  11. J. Dordick, Enzyme Microb. Technol. 11, 194 (1989).

    Article  CAS  Google Scholar 

  12. G. Carrea, S. Riva, R. Bovara, and P. Pasta, Enzyme Microb. Technol. 10, 333 (1988).

    Article  CAS  Google Scholar 

  13. R. D. Schwartz and C. J. McCoy, Appl. Environ. Microbiol. 34, 47 (1977).

    PubMed  CAS  Google Scholar 

  14. B. C. Buckland, P. Dunnill, and M. D. Lilly, Biotechnol. Bioeng. 17, 815 (1975).

    Article  CAS  Google Scholar 

  15. G. A. Homandberg, J. A. Mattis, and M. Laskowski, Jr., Biochemistry 17, 5220 (1978).

    Article  PubMed  CAS  Google Scholar 

  16. C. F. Barbas, J. R. Matos, J. B. West, and C.-H. Wong, J. Amer. Chem. Soc. 110, 5162 (1988).

    Article  CAS  Google Scholar 

  17. K. Martinek, A. V. Levashov, Y. L. Khmelnitski, N. L. Klyachko, and I. V. Berezin, Science 218, 889 (1982).

    Article  PubMed  CAS  Google Scholar 

  18. J. A. McCammon, B. R. Gelin, and M. Karplus, Nature 267, 585 (1977).

    Article  PubMed  CAS  Google Scholar 

  19. J. A. Rupley, E. Gratton, and G. Caren, Trends Biochem. Sci. 8, 18 (1983).

    Article  CAS  Google Scholar 

  20. G. Careri, E. Gratton, P. H. Yang, and J. A. Rupley, Nature 284, 572 (1980).

    Article  PubMed  CAS  Google Scholar 

  21. J. E. Schinkel, N. W. Downer, and J. A. Rupley, Biochemistry 24, 352 (1985).

    Article  PubMed  CAS  Google Scholar 

  22. S. Bone, Biochim. Biophys. Acta 916, 128 (1987).

    Article  PubMed  CAS  Google Scholar 

  23. A. Zaks and A. M. Klibanov, J. Biot Chem. 263, 8017 (1988).

    CAS  Google Scholar 

  24. A. Zaks and A. M. Klibanov, Proc. Natl. Acad. Sci. USA 82, 3192 (1985).

    Article  PubMed  CAS  Google Scholar 

  25. C. Laane, S. Boeren, K. Vos, and C. Veeger, Biotechnol. Bioeng. 30, 81 (1987).

    Article  PubMed  CAS  Google Scholar 

  26. A. Zaks and A. M. Klibanov, J. Biol. Chem. 263, 3194 (1988).

    PubMed  CAS  Google Scholar 

  27. L. E. S. Brink and J. Tramper, Biotechnol. Bioeng. 27, 1258 (1985).

    Article  PubMed  CAS  Google Scholar 

  28. P. J. Hailing, Trends Biotechnol. 7, 50 (1989).

    Article  Google Scholar 

  29. M. Reslow, P. Adlercreutz, and B. Mattiasson, Eur. J. Biochem. 172, 573 (1988).

    Article  PubMed  CAS  Google Scholar 

  30. K. Takahashi, Y. Kodera, T. Yoshimoto, A. Ajima, A. Matsushima, and Y. Inada, Biochem. Biophys. Res. Commun. 131, 532 (1985).

    Article  PubMed  CAS  Google Scholar 

  31. A. Matsushima, M. Okada, and Y. Inada, FEBS. Lett. 178, 275 (1984).

    Article  PubMed  CAS  Google Scholar 

  32. K. Takahashi, A. Ajima, T. Yoshimoto, and Y. Inada, Biochem. Biophys. Res. Commun. 125, 761 (1984).

    Article  PubMed  CAS  Google Scholar 

  33. K. Takahashi, H. Nishimura, T. Yoshimoto, Y. Saito, and Y. Inada, Biochem. Biophys. Res. Commun. 121, 261 (1984).

    Article  PubMed  CAS  Google Scholar 

  34. A. Zaks and A. M. Klibanov, J. Am. Chem. Soc. 108, 2767 (1986).

    Article  CAS  Google Scholar 

  35. A. J. Russell and A. M. Klibanov, J. Biol. Chem. 263, 11624 (1988).

    PubMed  CAS  Google Scholar 

  36. N. Chinsky, A. L. Margolin, and A. M. Klibanov, J. Amer. Chem. Soc. 111, 386 (1989).

    Article  CAS  Google Scholar 

  37. T. Sakurai, A. L. Margolin, A. J. Russell, and A. M. Klibanov, J. Amer. Chem. Soc. 110, 7236 (1988).

    Article  CAS  Google Scholar 

  38. C.-S. Chen and C. J. Sih, Angew. Chem. Int. Ed. Engl. 28, 695 (1989).

    Article  Google Scholar 

  39. S. J. Singer, Adv. Protein Chem. 17, 1 (1962).

    Article  CAS  Google Scholar 

  40. N. J. Solli and T. T. Herskovits, Anal. Biochem. 54, 370 (1973).

    Article  PubMed  CAS  Google Scholar 

  41. M. Winkler and P. Doty, Biochim. Biophys. Acta 54, 488 (1961).

    Article  Google Scholar 

  42. T. T. Herskovits, B. Gadegbeku, and H. Juliet, J. Biol. Chem. 245, 2588 (1970).

    PubMed  CAS  Google Scholar 

  43. E. P. Pittz and S. Timasheff, Biochemistry 17, 615 (1978).

    Article  PubMed  CAS  Google Scholar 

  44. T. Arakawa and S. Timasheff, Biochemistry 21, 6536 (1982).

    Article  PubMed  CAS  Google Scholar 

  45. L. T. Kanerva and A. M. Klibanov, J. Amer. Chem. Soc. 111, 6864 (1989).

    Article  CAS  Google Scholar 

  46. P. A. Burke, S. O. Smith, W. W. Bachovchin, and A. M. Klibanov, J. Amer. Chem. Soc. 111, 8290 (1989).

    Article  CAS  Google Scholar 

  47. A. Zaks and A. M. Klibanov, Science 224, 1249 (1984).

    Article  PubMed  CAS  Google Scholar 

  48. G. Ayala, M. Tuena de Gomez-Puyou, A. Gomez-Puyou, and A. Darzon, FEBS Lett. 203, 41 (1986).

    Article  PubMed  CAS  Google Scholar 

  49. G. Garza-Ramos, A. Darszon, M. Tuena de Gomez-Puyou, and A. Gomez-Puyou, Biochemistry 28, 3177 (1989).

    Article  PubMed  CAS  Google Scholar 

  50. C. J. Wheeler and R. Croteau, Arch. Biochem. Biophys. 248, 429 (1986).

    Article  PubMed  CAS  Google Scholar 

  51. M. Reslow, P. Adlercreutz, and B. Mattiasson, Appl. Microbiol. Biotechnol. 26, 1 (1987).

    Article  CAS  Google Scholar 

  52. A. R. Macrae, J. Am. Oil Chem. Soc. 60, 243 (1983).

    Article  Google Scholar 

  53. A. P. Ison, P. Dunnill, and M. D. Lilly, Enzyme Microb. TechnoL 10, 47 (1988).

    Article  CAS  Google Scholar 

  54. G. Kirchner, M. P. Scollar, and A. M. Klibanov, J. Am. Chem. Soc. 107, 7072 (1985).

    Article  CAS  Google Scholar 

  55. S. Koshiro, K. Sonomoto, A. Tanaka, and S. Fukui, J. Biotechnol. 2, 47 (1985).

    Article  CAS  Google Scholar 

  56. D. Bianchi, P. Cesti, and E. Battistel, J. Org. Chem. 53, 5531 (1988).

    Article  CAS  Google Scholar 

  57. J. Hiratake, M. Inagaki, T. Nishioka, and J. Oda, J. Org. Chem. 53, 6130 (1988).

    Article  CAS  Google Scholar 

  58. G. Langrand, J. Baratti, G. Buono, and C. Triantaphylides, Tetrahedron Lett. 27, 29 (1986).

    Article  CAS  Google Scholar 

  59. G. Gil, E. Ferre, A. Meou, J. Le Petit, and C. Triantaphylides, Tetrahedron Lett. 28, 1647 (1987).

    Article  CAS  Google Scholar 

  60. H. Kitaguchi, P. A. Fitzpatrick, J. E. Huber, and A. M. Klibanov, J. Amer. Chem. Soc. 111, 3094 (1989).

    Article  CAS  Google Scholar 

  61. A. L. Gutman, K. Zuobi, and A. Boltansky, Tetrahedron Lett. 28, 3861 (1987).

    Article  CAS  Google Scholar 

  62. A. Makita, T. Nihira, and Y. Yamada, Tetrahedron Lett. 28, 805 (1987).

    Article  CAS  Google Scholar 

  63. Z.-W. Guo and C. J. Sih, J. Amer. Chem. Soc. 110, 1999 (1988).

    Article  CAS  Google Scholar 

  64. A. L. Margolin, J.-Y. Crenne, and A. M. Klibanov, Tetrahedron Lett. 28, 1607 (1987).

    Article  CAS  Google Scholar 

  65. M. Therisod and A. M. Klibanov, J. Am. Chem. Soc. 108, 5638 (1986).

    Article  CAS  Google Scholar 

  66. M. Therisod and A. M. Klibanov, J. Am. Chem. Soc. 109, 3977 (1987).

    Article  CAS  Google Scholar 

  67. W. J. Hennen, H. M. Sweers, Y.-F. Wang, and C.-H. Wong, J. Org. Chem. 53, 4939 (1988).

    Article  CAS  Google Scholar 

  68. Y.-F. Wang, J. J. Lalonde, M. Momongan, D. E. Bergbreiter, and C.-H. Wong, J. Amer. Chem. Soc. 110, 7200 (1988).

    Article  CAS  Google Scholar 

  69. J. Chopineau, F. D. McCafferty, M. Therisod, and A. M. Klibanov, Biotechnol. Bioeng. 31, 208 (1988).

    Article  PubMed  CAS  Google Scholar 

  70. S. Riva and A. Klibanov, J. Amer. Chem. Soc. 110, 3291 (1988).

    Article  CAS  Google Scholar 

  71. S. Riva, J. Chopineau, A. P. G. Kieboom, and A. Klibanov, J. Amer. Chem. Soc. 110, 584 (1988).

    Article  CAS  Google Scholar 

  72. W. Kullmann, Enzymatic Peptide Synthesis, CRC Press (1987).

    Google Scholar 

  73. K. Oyama, S. Nishimura, Y. Nonaka, K. Kihara, and T. Hashimoto, J. Org. Chem. 46, 5241 (1981).

    Article  CAS  Google Scholar 

  74. H. Kise, A. Hayakawa, and H. Noritomi, Biotechnol. Lett. 9, 543 (1987).

    Article  CAS  Google Scholar 

  75. A. L. Margolin and A. M. Klibanov, J. Am. Chem. Soc. 109, 3802 (1987).

    Article  CAS  Google Scholar 

  76. J. B. West and C.-H. Wong, Tetrahedron Lett. 28, 1629 (1987).

    Article  CAS  Google Scholar 

  77. J. Grunwald, B. Wirz, M. P. Scollar, and A. M. Klibanov, J. Amer. Chem. Soc. 108, 6732 (1986).

    Article  CAS  Google Scholar 

  78. R. Z. Kazandjian and A. M. Klibanov, J. Amer. Chem. Soc. 107, 5448 (1986).

    Article  Google Scholar 

  79. J. S. Dordick, M. A. Marietta, and A. M. Klibanov, Biotechnol. Bioeng. 30, 31 (1987).

    Article  PubMed  CAS  Google Scholar 

  80. R. Z. Kazandjian, J. S. Dordick, and A. M. Klibanov, Biotechnol. Bioeng. 28, 417 (1986).

    Article  PubMed  CAS  Google Scholar 

  81. F. R. Dastoli and S. Price, Arch. Biochem. Biophys. 118, 163 (1967).

    Article  CAS  Google Scholar 

  82. F. R. Dastoli and S. Price, Arch. Biochem. Biophys. 122, 289 (1967).

    Article  CAS  Google Scholar 

  83. F. R. Dastoli, N. A. Musto, and S. Price, Arch. Biochem. Biophys. 115, 44 (1966).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Enzytech, Inc., 64 Sidney St., Cambridge, MA, 02139, USA

    Aleksey Zaks

Authors
  1. Aleksey Zaks
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Chemical and Biochemical Engineering, The University of Iowa, 52242, Iowa City, Iowa, USA

    Jonathan S. Dordick

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Zaks, A. (1991). Enzymes in Organic Solvents. In: Dordick, J.S. (eds) Biocatalysts for Industry. Topics in Applied Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4597-9_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-4597-9_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3216-7

  • Online ISBN: 978-1-4757-4597-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation